Inflammation, Frailty, and Aspirin Use in the Physicians’ Health Study: A Pilot Study

Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. Jun 06 2013;153(6):1194–217. doi:https://doi.org/10.1016/j.cell.2013.05.039

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen L, Deng H, Cui H, et al. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. Jan 23 2018;9(6):7204–7218. doi:https://doi.org/10.18632/oncotarget.23208

Article  PubMed  Google Scholar 

Justice JN, Ferrucci L, Newman AB, et al. A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup. GeroScience. Dec 2018;40(5–6):419–436. doi:https://doi.org/10.1007/s11357-018-0042-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH. Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men. New England Journal of Medicine. 1997;336(14):973–979. doi:https://doi.org/10.1056/nejm199704033361401

Article  CAS  PubMed  Google Scholar 

Vane JR, Botting RM. The mechanism of action of aspirin. Thromb Res. Jun 15 2003;110(5–6):255–8.

Article  CAS  PubMed  Google Scholar 

Orkaby AR, Yang L, Dufour AB, et al. Association Between Long-Term Aspirin Use and Frailty in Men: The Physicians’ Health Study. The journals of gerontology Series A, Biological sciences and medical sciences. Sep 11 2020;doi:https://doi.org/10.1093/gerona/glaa233

Espinoza SE, Woods RL, Ekram A, et al. The effect of low-dose aspirin on frailty phenotype and frailty index in community-dwelling older adults in the ASPirin in Reducing Events in the Elderly study. J Gerontol A Biol Sci Med Sci. Nov 10 2021;doi:https://doi.org/10.1093/gerona/glab340

Orkaby AR, Dufour AB, Yang L, et al. Long-Term Aspirin Use and Self-Reported Walking Speed in Older Men: The Physicians’ Health Study. The Journal of Frailty & Aging. 2021/09/17 2021;doi:https://doi.org/10.14283/jfa.2021.36

Final report on the aspirin component of the ongoing Physicians’ Health Study. Steering Committee of the Physicians’ Health Study Research Group. The New England journal of medicine. Jul 20 1989;321(3):129–35. doi:https://doi.org/10.1056/nejm198907203210301

Article  Google Scholar 

Cook NR, Le IM, Manson JE, Buring JE, Hennekens CH. Effects of beta-carotene supplementation on cancer incidence by baseline characteristics in the Physicians’ Health Study (United States). Cancer causes & control: CCC. Aug 2000;11(7):617–26.

Article  CAS  PubMed  Google Scholar 

Gaziano JM, Sesso HD, Christen WG, et al. Multivitamins in the prevention of cancer in men: the Physicians’ Health Study II randomized controlled trial. Jama. Nov 14 2012;308(18):1871–80. doi:https://doi.org/10.1001/jama.2012.14641

Article  CAS  PubMed  PubMed Central  Google Scholar 

Searle SD, Mitnitski A, Gahbauer EA, Gill TM, Rockwood K. A standard procedure for creating a frailty index. BMC Geriatr. 2008;8:24. doi:https://doi.org/10.1186/1471-2318-8-24

Article  PubMed  PubMed Central  Google Scholar 

Orkaby AR, Hshieh TT, Gaziano JM, Djousse L, Driver JA. Comparison of two frailty indices in the physicians’ health study. Archives of gerontology and geriatrics. Jul 2017;71:21–27. doi:https://doi.org/10.1016/j.archger.2017.02.009

Article  PubMed  PubMed Central  Google Scholar 

Jimenez MC, Rexrode KM, Glynn RJ, Ridker PM, Gaziano JM, Sesso HD. Association Between High-Sensitivity C-Reactive Protein and Total Stroke by Hypertensive Status Among Men. Journal of the American Heart Association. Sep 21 2015;4(9):e002073. doi:https://doi.org/10.1161/JAHA.115.002073

Article  PubMed  PubMed Central  Google Scholar 

Pawar D, Shahani S, Maroli S. Aspirin—the novel antiplatelet drug. Hong Kong medical journal = Xianggang yi xue za zhi. Dec 1998;4(4):415–418.

CAS  PubMed  Google Scholar 

Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. Mar 2 2013;381(9868):752–62. doi:https://doi.org/10.1016/s0140-6736(12)62167-9

Article  PubMed  Google Scholar 

Luan YY, Yao YM. The Clinical Significance and Potential Role of C-Reactive Protein in Chronic Inflammatory and Neurodegenerative Diseases. Front Immunol. 2018;9:1302. doi:https://doi.org/10.3389/fimmu.2018.01302

Article  PubMed  PubMed Central  Google Scholar 

Maggio M, Guralnik JM, Longo DL, Ferrucci L. Interleukin-6 in aging and chronic disease: a magnificent pathway. The journals of gerontology Series A, Biological sciences and medical sciences. Jun 2006;61(6):575–84. doi:https://doi.org/10.1093/gerona/61.6.575

Article  PubMed  Google Scholar 

Soysal P, Stubbs B, Lucato P, et al. Inflammation and frailty in the elderly: A systematic review and meta-analysis. Ageing research reviews. Nov 2016;31:1–8. doi:https://doi.org/10.1016/j.arr.2016.08.006

Article  CAS  PubMed  Google Scholar 

留言 (0)

沒有登入
gif