Argyriou AA, Kyritsis AP, Makatsoris T, Kalofonos HP (2014) Chemotherapy-induced peripheral neuropathy in adults: a comprehensive update of the literature. Cancer Manag Res 6:135–147

Article  PubMed  PubMed Central  Google Scholar 

Bih CI, Chen T, Nunn AVW, Bazelot M, Dallas M, Whalley BJ (2015) Molecular targets of cannabidiol in neurological disorders. Neurotherap 12:699–730

Article  CAS  Google Scholar 

Bonezzi C, Demartini L (1999) Treatment options in postherpetic neuralgia. Acta Neurol Scand 173:25–35

Article  CAS  Google Scholar 

Brenneman DE, Petkanas D, Kinney WA (2018) Pharmacological comparisons between cannabidiol and KLS-13019. J Mol Neurosci 66:121–134

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brenneman DE, Kinney WA, Ward SJ (2019) Knockdown siRNA targeting the mitochondrial sodium-channel WA exchanger-1 inhibits the protective effects of two cannabinoids against acute paclitaxel toxicity. J Mol Neurosci 68:603–619

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brenneman DE, Kinney WA, McDonnell ME, Zhao P, Abood ME, Ward SJ (2022) Anti-inflammatory properties of KLS-13019: a novel GPR55 antagonist for dorsal root ganglion and hippocampal cultures. J Mol Neurosci 72:1859–1874

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen L-H, Sun Y-T, Chen Y-F, Lee M-Y, Chang L-Y, Chang J-Y, Shen M-R (2015) Integrating image-based high-content screening with mouse models identifies 5-hydroxydecanoate as a neuroprotective drug for paclitaxel-induced neuropathy. Mol Cancer Ther 14:2206–2214

Article  CAS  PubMed  Google Scholar 

Cherif H, Argaw A, Cecyre B, Bouchard A, Gagnon J, Javadi P, Desgent S, Mackie K, Bouchard J-F (2015) Role of GPR55 during axon growth and target innervation. eNeuro 2:11–15. https://doi.org/10.1523/ENEURO.0011-15.2015

Article  Google Scholar 

Chiurchiu GV, Lanuti M, De Bardi M, Battistini L, Maccarrone M (2015) The differential characterization of GPR55 receptor in human peripheral blood reveals a distinctive expression in monocytes and NK cells and a proinflammatory role in these innate cells. Int Immunol 27:153–160

Article  CAS  PubMed  Google Scholar 

Dedov VN, Roufogalis BD (1999) Organization of mitochondria in living sensory neurons. FEBS Lett 456:171–174

Article  CAS  PubMed  Google Scholar 

Dellemijn P (1999) Are opioids effective in relieving neuropathic pain? Pain 80(3):453–462

Article  CAS  PubMed  Google Scholar 

Fedorovich SV, Waseem TV, Puchkova LY (2017) Biogenetic and morphofunctional heterogeneity of mitochondria: the case of synaptic mitochondria. Rev Neurosci 28:363–373

Article  CAS  PubMed  Google Scholar 

Foss JD, Farkas DJ, Huynh LM, Kinney WA, Brenneman DE, Ward SJ (2021) Behavioral and pharmacological effects of cannabidiol (CBD) and the CBD analogue KLS-13019 in mouse models of pain and reinforcement. Brit J Pharmacol 178:3067–3078

Article  CAS  Google Scholar 

Fumagalli G, Monza L, Cavaletti G, Rigolio R, Meregalli C (2021) Neuroinflammatory process involved in different preclinical models of chemotherapy-induced peripheral neuropathy. Front Immunol. https://doi.org/10.3389/fimmu.2020.626687.eCollection2020

Article  PubMed  PubMed Central  Google Scholar 

Guerrero-Alba R, Barragan-Iglesias P, Gonzalez-Hernandez A, Valdez-Morales E, Granado-Soto V, Condes-Lara M, Rodriguez M, Marichal-Cancino B (2019) Some prospective alternative for treating pain: the endocannabinoid system and its putative receptors GPR18 and GPR55. Front Pharmacol 9:1–20

Article  Google Scholar 

Gutierrez-Gutierrez GM, Sereno, et al (2010) Chemotherapy-induced peripheral neuropathy: clinical features, diagnosis, prevention and treatment strategies. Clin Transl Oncol 12(2):81–91

Article  PubMed  Google Scholar 

Hemstreet B, Lapointe M (2001) Evidence for the use of gabapentin in the treatment of diabetic peripheral neuropathy. Clin Ther 23(4):520–531

Article  CAS  PubMed  Google Scholar 

Kelley N, Jeltema D, Duan Y, He Y (2019) The NLRP3 inflammasome: an overview of mechanisms of activation and regulation. Intl J Mol Sci 20:3328

Article  CAS  Google Scholar 

King KM, Myers AM, Soroka-Monzo AJ, Tuma RF, Tallarida RJ, Walker EA, Ward SJ (2017) Single and combined effects of D9-tetrahydrocannabinol and cannabidiol in a mouse model of chemotherapy-induced neuropathic pain. Brit J Pharmacol 174:2832–2841

Article  CAS  Google Scholar 

Kinney WA, McDonnell ME, Zhong HM, Liu C, Yang L, Ling W, Qian T, Chen Y, Cai Z, Petkanas D, Brenneman DE (2016) Discovery of KLS-13019, a cannabidiol-derived neuroprotective agent, with improved potency, safety, and permeability. ACS Med Chem Lett 7:424–428

Article  CAS  PubMed  PubMed Central  Google Scholar 

Koyanagi M, Imai S, Matsumoto M, Iguma Y, Kawaguchi-Sakita N, Kotake T et al (2021) Pronociceptive roles of Schwann cell-derived galectin-3 in taxanes-induced peripheral neuropathy. Cancer Res. https://doi.org/10.1158/0008-5472.CAN-20-2799

Article  PubMed  Google Scholar 

Krames ES (2014) The role of the dorsal root ganglion in the development of neuropathic pain. Pain Med 15:1669–1685

Article  PubMed  Google Scholar 

Kulbe JR, Hill RL, Singh IN, Wang JA, Hall ED (2017) Synaptic mitochondria sustain more damage than non-synaptic mitochondria after traumatic brain injury and are protected by cyclosporin A. J Neurotrauma 34:1291–1301

Article  PubMed  PubMed Central  Google Scholar 

Kuznetsov AV, Margreiter R (2009) Heterogeneity of mitochondria and mitochondrial function within cells as another level of mitochondrial complexity. Int J Mol Sci 10:1911–1929

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lees JG, Mokker PGS, Tonkin RS, Abdulla M, Park S, Goldstein D, Moolem-Taylor G (2017) Immune-mediated processes implicated in chemotherapy-induced peripheral neuropathy. Eur J Cancer 73:22–29

Article  CAS  PubMed  Google Scholar 

Makker PGS, Duffy SS, Lees JG, Perera CJ, Tonkin RS et al (2017) Characterization of immune and neuroinflammatory changes associated with chemotherapy-induced peripheral neuropathy. PLoS ONE 12(1):e0170814. https://doi.org/10.1371/journal.pone.0170814

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nielsen SW, Hasselsteen SD, Dominiak HSH, Labudovic D, Reiter L, Dalton SO, Herrstedt J (2022) Oral cannabidiol for prevention of acute and transient chemotherapy-induced peripheral neuropathy. Support Care Cancer 30:9441–9451

Article  PubMed  Google Scholar 

Obara Y, Ueno S, Yanagihata Y, Nakahata N (2011) Lysophosphatidylinositol causes neurite retraction via GPR55, G13 and RhoA in PC12 cells. PLoS ONE 6:e24284

Article  CAS  PubMed  PubMed Central  Google Scholar 

Okine BN, Mc Laughlin G, Gaspar JC, Harhen B, Roche M, Finn DP (2020) Antinociceptive effects on the GPR55 antagonists CID16020046 injected into the rat anterior cingulate cortex. Neurosci 443:19–29

Article  CAS  Google Scholar 

Peters CM, Jimenez-Andrade JM, Jonas BM, Sevcik MA, Koewler NJ, Ghilardi JR, Wong GY, Mantyh PW (2007) Intravenous paclitaxel administration in the rat induces a peripheral sensory neuropathy characterized by macrophage infiltration and injury to sensory neurons and their supporting cells. Exp Neurol 203(1):42–54. https://doi.org/10.1016/j.brainres.2007.06.066. Epub 2007 Jul 17

Article  CAS  PubMed  Google Scholar 

Schuelert N, McDougall J (2011) The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55. Neurosci Lett 500:72–76

Article  CAS  PubMed  Google Scholar 

Scuteri A, Nicolini G, Miloso M, Bossi M, Cavaletti G, Windebank AJ, Tredici G (2006) Paclitaxel toxicity in post-mitotic dorsal root ganglion (DRG) cells. Anticancer Res 26:1065–1070

CAS  PubMed  Google Scholar 

Shan L, Xu K, Ji L, Zeng Q, Liu Y, Wu Y, Chen Y, Li Y, Hu Q, Wu J et al (2024) Injured sensory neurons-derived galectin-3 contributes to neuropathic pain via programming microglia in the spinal dorsal horn. Brain Behav Immun 117:80–99

Article  CAS  PubMed  Google Scholar 

Staton PC, Hatcher JP, Walker DJ, Morrison AD, Shapland EN, Hughes JP, Chong E, Mander PK et al (2008) The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain. Pain 139:225–236

Article  CAS  PubMed  Google Scholar 

Ward SJ, Ramirez MD, Neelakantan H, Walker EA (2011) Cannabidiol prevents the development of cold and mechanical allodynia in paclitaxel-treated female C57Bl6 mice. Anesth Analg 113:947–950

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ward SJ, McAllister SD, Kawamura R, Murase R, Neelakantan H, Walker EA (2014) Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT1A receptors without diminishing nervous system function or chemotherapy efficacy. Brit J Pharmacol 171:636–645

Article  CAS  Google Scholar