Qin X, Wang X. Role of vitamin d receptor in the regulation of cyp3a gene expression. Acta Pharm Sin B. 2019;9:1087–98.

Article  PubMed  PubMed Central  Google Scholar 

Wang L, Zhou S, Guo B. Vitamin d suppresses ovarian cancer growth and invasion by targeting long non-coding rna ccat2. Int J Mol Sci 2020, 21.

Gocek E, Studzinski GP. Vitamin d and differentiation in cancer. Crit Rev Clin Lab Sci. 2009;46:190–209.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang Z, Zhang Y, Li H, Zhou Y, Zhang Q, Chen R, Jin T, Hu K, Li S, Wang Y, et al. Vitamin d promotes the cisplatin sensitivity of oral squamous cell carcinoma by inhibiting lcn2-modulated nf-kappab pathway activation through rps3. Cell Death Dis. 2019;10:936.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kang Z, Wang C, Tong Y, Li Y, Gao Y, Hou S, Hao M, Han X, Wang B, Wang Q, Zhang C. Novel nonsecosteroidal vitamin d receptor modulator combined with gemcitabine enhances pancreatic cancer therapy through remodeling of the tumor microenvironment. J Med Chem. 2021;64:629–43.

Article  CAS  PubMed  Google Scholar 

Song M, Nishihara R, Wang M, Chan AT, Qian ZR, Inamura K, Zhang X, Ng K, Kim SA, Mima K, et al. Plasma 25-hydroxyvitamin d and colorectal cancer risk according to tumour immunity status. Gut. 2016;65:296–304.

Article  CAS  PubMed  Google Scholar 

Zhang Y, Fang F, Tang J, Jia L, Feng Y, Xu P, Faramand A. Association between vitamin d supplementation and mortality: systematic review and meta-analysis. BMJ. 2019;366:l4673.

Article  PubMed  PubMed Central  Google Scholar 

Emmanouilidou G, Kalopitas G, Bakaloudi DR, Karanika E, Theocharidou E, Germanidis G, Chourdakis M. Vitamin d as a chemopreventive agent in colorectal neoplasms. A systematic review and meta-analysis of randomized controlled trials. Pharmacol Ther. 2022;237:108252.

Article  CAS  PubMed  Google Scholar 

Visvanathan K, Mondul AM, Zeleniuch-Jacquotte A, Wang M, Gail MH, Yaun SS, Weinstein SJ, McCullough ML, Eliassen AH, Cook NR, et al. Circulating vitamin d and breast cancer risk: an international pooling project of 17 cohorts. Eur J Epidemiol. 2023;38:11–29.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Van Loon K, Owzar K, Jiang C, Kindler HL, Mulcahy MF, Niedzwiecki D, O’Reilly EM, Fuchs C, Innocenti F, Venook AP. Alliance for clinical trials in O: 25-hydroxyvitamin d levels and survival in advanced pancreatic cancer: findings from calgb 80303 (alliance). J Natl Cancer Inst 2014, 106.

McGovern EM, Lewis ME, Niesley ML, Huynh N, Hoag JB. Retrospective analysis of the influence of 25-hydroxyvitamin d on disease progression and survival in pancreatic cancer. Nutr J. 2016;15:17.

Article  PubMed  PubMed Central  Google Scholar 

Waterhouse M, Risch HA, Bosetti C, Anderson KE, Petersen GM, Bamlet WR, Cotterchio M, Cleary SP, Ibiebele TI, La Vecchia C, et al. Vitamin d and pancreatic cancer: a pooled analysis from the pancreatic cancer case-control consortium. Ann Oncol. 2015;26:1776–83.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Y, Zhao Z, Lin CY, Liu Y, Staveley OKF, Li G, Cheng K. Silencing pcbp2 normalizes desmoplastic stroma and improves the antitumor activity of chemotherapy in pancreatic cancer. Theranostics. 2021;11:2182–200.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu X, Hu W, Lu L, Zhao Y, Zhou Y, Xiao Z, Zhang L, Zhang H, Li X, Li W, et al. Repurposing vitamin d for treatment of human malignancies via targeting tumor microenvironment. Acta Pharm Sin B. 2019;9:203–19.

Article  PubMed  Google Scholar 

Lu M, Taylor BV, Korner H. Genomic effects of the vitamin d receptor: potentially the link between vitamin d, immune cells, and multiple sclerosis. Front Immunol. 2018;9:477.

Article  PubMed  PubMed Central  Google Scholar 

Ferrer-Mayorga G, Gomez-Lopez G, Barbachano A, Fernandez-Barral A, Pena C, Pisano DG, Cantero R, Rojo F, Munoz A, Larriba MJ. Vitamin d receptor expression and associated gene signature in tumour stromal fibroblasts predict clinical outcome in colorectal cancer. Gut. 2017;66:1449–62.

Article  CAS  PubMed  Google Scholar 

Wei C, Yang C, Wang S, Shi D, Zhang C, Lin X, Liu Q, Dou R, Xiong B. Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circulating tumor cell-mediated colorectal cancer metastasis. Mol Cancer. 2019;18:64.

Article  PubMed  PubMed Central  Google Scholar 

Hu PS, Li T, Lin JF, Qiu MZ, Wang DS, Liu ZX, Chen ZH, Yang LP, Zhang XL, Zhao Q, et al. Vdr-sox2 signaling promotes colorectal cancer stemness and malignancy in an acidic microenvironment. Signal Transduct Target Ther. 2020;5:183.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lurie G, Wilkens LR, Thompson PJ, McDuffie KE, Carney ME, Terada KY, Goodman MT. Vitamin d receptor gene polymorphisms and epithelial ovarian cancer risk. Cancer Epidemiol Biomarkers Prev. 2007;16:2566–71.

Article  CAS  PubMed  Google Scholar 

Huss L, Butt ST, Borgquist S, Elebro K, Sandsveden M, Rosendahl A, Manjer J. Vitamin d receptor expression in invasive breast tumors and breast cancer survival. Breast Cancer Res. 2019;21:84.

Article  PubMed  PubMed Central  Google Scholar 

Solomon JD, Heitzer MD, Liu TT, Beumer JH, Parise RA, Normolle DP, Leach DA, Buchanan G, DeFranco DB. Vdr activity is differentially affected by hic-5 in prostate cancer and stromal cells. Mol Cancer Res. 2014;12:1166–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kitami K, Yoshihara M, Tamauchi S, Sugiyama M, Koya Y, Yamakita Y, Fujimoto H, Iyoshi S, Uno K, Mogi K, et al. Peritoneal restoration by repurposing vitamin d inhibits ovarian cancer dissemination via blockade of the tgf-beta1/thrombospondin-1 axis. Matrix Biol. 2022;109:70–90.

Article  CAS  PubMed  Google Scholar 

Urashima M, Ohdaira H, Akutsu T, Okada S, Yoshida M, Kitajima M, Suzuki Y. Effect of vitamin d supplementation on relapse-free survival among patients with digestive tract cancers: the Amaterasu randomized clinical trial. JAMA. 2019;321:1361–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wei D, Wang L, Liu Y, Hafley MA, Tan L, Lorenzi PL, Yang P, Zuo X, Bresalier RS. Activation of vitamin d/vdr signaling reverses gemcitabine resistance of pancreatic cancer cells through inhibition of muc1 expression. Dig Dis Sci. 2023;68:3043–58.

Article  CAS  PubMed  Google Scholar 

Li Z, Jia Z, Gao Y, Xie D, Wei D, Cui J, Mishra L, Huang S, Zhang Y, Xie K. Activation of vitamin d receptor signaling downregulates the expression of nuclear foxm1 protein and suppresses pancreatic cancer cell stemness. Clin Cancer Res. 2015;21:844–53.

Article  CAS  PubMed  Google Scholar 

Lowry MB, Guo C, Zhang Y, Fantacone ML, Logan IE, Campbell Y, Zhang W, Le M, Indra AK, Ganguli-Indra G, et al. A mouse model for vitamin d-induced human cathelicidin antimicrobial peptide gene expression. J Steroid Biochem Mol Biol. 2020;198:105552.

Article  CAS  PubMed  Google Scholar 

Liu WC, Zheng CM, Lu CL, Lin YF, Shyu JF, Wu CC, Lu KC. Vitamin d and immune function in chronic kidney disease. Clin Chim Acta. 2015;450:135–44.

Article  CAS  PubMed  Google Scholar 

Zhu X, Zhu Y, Li C, Yu J, Ren D, Qiu S, Nie Y, Yu X, Xu X, Zhu W. 1,25–dihydroxyvitamin d regulates macrophage polarization and ameliorates experimental inflammatory bowel disease by suppressing mir-125b. Int Immunopharmacol. 2019;67:106–18.

Article  CAS  PubMed  Google Scholar 

Liu D, Fang YX, Wu X, Tan W, Zhou W, Zhang Y, Liu YQ, Li GQ. 1,25-(oh)(2)d(3)/vitamin d receptor alleviates systemic lupus erythematosus by downregulating skp2 and upregulating p27. Cell Commun Signal. 2019;17:163.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Lyu Z, Qin Y, Wang X, Sun L, Zhang Y, Gong L, Wu S, Han S, Tang Y, et al. Foxo1 promotes tumor progression by increased m2 macrophage infiltration in esophageal squamous cell carcinoma. Theranostics. 2020;10:11535–48.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie T, Fu DJ, Li ZM, Lv DJ, Song XL, Yu YZ, Wang C, Li KJ, Zhai B, Wu J, et al. Circsmarcc1 facilitates tumor progression by disrupting the crosstalk between prostate cancer cells and tumor-associated macrophages via mir-1322/ccl20/ccr6 signaling. Mol Cancer. 2022;21:173.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martorell S, Hueso L, Gonzalez-Navarro H, Collado A, Sanz MJ, Piqueras L. Vitamin d receptor activation reduces angiotensin-ii-induced dissecting abdominal aortic aneurysm in apolipoprotein e-knockout mice. Arterioscler Thromb Vasc Biol. 2016;36:1587–97.

Article  CAS  PubMed  Google Scholar 

Peran I, Dakshanamurthy S, McCoy MD, Mavropoulos A, Allo B, Sebastian A, Hum NR, Sprague SC, Martin KA, Pishvaian MJ, et al. Cadherin 11 promotes immunosuppression and extracellular matrix deposition to support growth of pancreatic tumors and resistance to gemcitabine in mice. Gastroenterology. 2021;160:1359–e13721313.

Article  CAS  PubMed  Google Scholar 

Schnittert J, Bansal R, Prakash J. Targeting pancreatic stellate cells in cancer. Trends Cancer. 2019;5:128–42.

Article  CAS  PubMed