Geraghty JR, Testai FD. Delayed cerebral ischemia after subarachnoid hemorrhage: beyond vasospasm and towards a multifactorial pathophysiology. Curr Atheroscler Rep. 2017;19(12):50.

Article  PubMed  Google Scholar 

Peeyush Kumar T, McBride DW, Dash PK, Matsumura K, Rubi A, Blackburn SL. Endothelial cell dysfunction and injury in subarachnoid hemorrhage. Mol Neurobiol. 2019;56(3):1992–2006.

Article  CAS  PubMed  Google Scholar 

Friedrich V, Flores R, Sehba FA. Cell death starts early after subarachnoid hemorrhage. Neurosci Lett. 2012;512(1):6–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zubkov AY, Ogihara K, Bernanke DH, Parent AD, Zhang J. Apoptosis of endothelial cells in vessels affected by cerebral vasospasm. Surg Neurol. 2000;53(3):260–6.

Article  CAS  PubMed  Google Scholar 

Aoki K, Zubkov AY, Ross IB, Zhang JH. Therapeutic effect of caspase inhibitors in the prevention of apoptosis and reversal of chronic cerebral vasospasm. J Clin Neurosci. 2002;9(6):672–7.

Article  CAS  PubMed  Google Scholar 

Zhou C, Yamaguchi M, Colohan AR, Zhang JH. Role of p53 and apoptosis in cerebral vasospasm after experimental subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2005;25(5):572–82.

Article  CAS  PubMed  Google Scholar 

Zhou C, Yamaguchi M, Kusaka G, Schonholz C, Nanda A, Zhang JH. Caspase inhibitors prevent endothelial apoptosis and cerebral vasospasm in dog model of experimental subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2004;24(4):419–31.

Article  CAS  PubMed  Google Scholar 

American Heart Association Stroke Council, Council on Cardiovascular Radiology and Intervention, Council on Cardiovascular Nursing; Council on Cardiovascular Surgery and Anesthesia, Council on Clinical Cardiology, Connolly ES Jr, Rabinstein AA, Carhuapoma JR, Derdeyn CP, Dion J, Higashida RT, et al. Guidelines for the management of aneurysmal subarachnoid hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2012;43(6):1711–37.

Article  Google Scholar 

Petruk KC, West M, Mohr G, Weir BK, Benoit BG, Gentili F, et al. Nimodipine treatment in poor-grade aneurysm patients. Results of a multicenter double-blind placebo-controlled trial. J Neurosurg. 1988;68(4):505–17.

Article  CAS  PubMed  Google Scholar 

Allen GS, Ahn HS, Preziosi TJ, Battye R, Boone SC, Boone SC, et al. Cerebral arterial spasm—a controlled trial of nimodipine in patients with subarachnoid hemorrhage. N Engl J Med. 1983;308(11):619–24.

Article  CAS  PubMed  Google Scholar 

Dorhout Mees SM, Rinkel GJ, Feigin VL, Algra A, van den Bergh WM, Vermeulen M, et al. Calcium antagonists for aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev. 2007;3:CD000277.

Google Scholar 

Pickard JD, Walker V, Vile J, Perry S, Smythe PJ, Hunt R. Oral nimodipine reduces prostaglandin and thromboxane production by arteries chronically exposed to a periarterial haematoma and the antifibrinolytic agent tranexamic acid. J Neurol Neurosurg Psychiatry. 1987;50(6):727–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roos YB, Levi M, Carroll TA, Beenen LF, Vermeulen M. Nimodipine increases fibrinolytic activity in patients with aneurysmal subarachnoid hemorrhage. Stroke. 2001;32(8):1860–2.

Article  CAS  PubMed  Google Scholar 

Wellman GC, Koide M. Impact of subarachnoid hemorrhage on parenchymal arteriolar function. Acta Neurochir Suppl. 2013;115:173–7.

Article  PubMed  PubMed Central  Google Scholar 

Juvela S, Kaste M, Hillbom M. Effect of nimodipine on platelet function in patients with subarachnoid hemorrhage. Stroke. 1990;21(9):1283–8.

Article  CAS  PubMed  Google Scholar 

Neil-Dwyer G, Mee E, Dorrance D, Lowe D. Early intervention with nimodipine in subarachnoid haemorrhage. Eur Heart J. 1987;8:41–7.

Article  PubMed  Google Scholar 

Sobrado M, López MG, Carceller F, García AG, Roda JM. Combined nimodipine and citicoline reduce infarct size, attenuate apoptosis and increase bcl-2 expression after focal cerebral ischemia. Neuroscience. 2003;118(1):107–13.

Article  CAS  PubMed  Google Scholar 

Horn J, de Haan RJ, Vermeulen M, Luiten PG, Limburg M. Nimodipine in animal model experiments of focal cerebral ischemia: a systematic review. Stroke. 2001;32(10):2433–8.

Article  CAS  PubMed  Google Scholar 

Kamasak K, Basarslan K, Dagli AT, Ogden M, Alabalik U, Ekinci A, et al. Effects of nimodipine and nigella sativa on oxidative stress and apoptosis in serum and brain tissue of rats with experimental head trauma. Turk Neurosurg. 2021;31(1):8–17.

PubMed  Google Scholar 

Onal MB, Civelek E, Kircelli A, Solmaz I, Ugurel S, Narin F, et al. Comparison of nimodipine delivery routes in cerebral vasospasm after subarachnoid hemorrhage: an experimental study in rabbits. Acta Neurochir Suppl. 2011;110(Pt 2):23–8.

PubMed  Google Scholar 

Findlay JM, Nisar J, Darsaut T. Cerebral vasospasm: a review. Can J Neurol Sci. 2016;43(1):15–32.

Article  PubMed  Google Scholar 

Nair A, Morsy MA, Jacob S. Dose translation between laboratory animals and human in preclinical and clinical phases of drug development. Drug Dev Res. 2018;79(8):373–82.

Article  CAS  PubMed  Google Scholar 

Srimaharaj W, Hemrungrote S, Chaisricharoen R. Cloud service for detection of human skin color. In: 2015 15th international symposium on communications and information technologies (ISCIT), Nara, Japan, IEEE; 2015. p. 9–12.https://doi.org/10.1109/ISCIT.2015.7458294. Accessed 7–9 Oct 2015.

Geraldini F, De Cassai A, Diana P, Correale C, Boscolo A, Zampirollo S, et al. A comparison between enteral and intravenous nimodipine in subarachnoid hemorrhage: a systematic review and network meta-analysis. Neurocrit Care. 2022;36(3):1071–9.

Article  CAS  PubMed  Google Scholar 

Dreier JP, Windmüller O, Petzold G, Lindauer U, Einhäupl KM, Dirnagl U. Ischemia triggered by red blood cell products in the subarachnoid space is inhibited by nimodipine administration or moderate volume expansion/hemodilution in rats. Neurosurgery. 2002;51(6):1457–65.

Article  PubMed  Google Scholar 

Morris JL, Gillet G, Prudent J, Popgeorgiev N. Bcl-2 family of proteins in the control of mitochondrial calcium signalling: an old chap with new roles. Int J Mol Sci. 2021;22(7):3730.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McConkey DJ, Orrenius S. The role of calcium in the regulation of apoptosis. Biochem Biophys Res Commun. 1997;239(2):357–66.

Article  CAS  PubMed  Google Scholar 

Ogihara K, Zubkov AY, Bernanke DH, Lewis AI, Parent AD, Zhang JH. Oxyhemoglobin-induced apoptosis in cultured endothelial cells. J Neurosurg. 1999;91(3):459–65.

Article  CAS  PubMed  Google Scholar 

Brandt L, Ljunggren B, Andersson KE, Edvinsson L, MacKenzie E, Tamura A, et al. Effects of topical application of a calcium antagonist (nifedipine) on feline cortical pial microvasculature under normal conditions and in focal ischemia. J Cereb Blood Flow Metab. 1983;3(1):44–50.

Article  CAS  PubMed  Google Scholar 

Auer LM, Mokry M. Effect of topical nimodipine versus its ethanol-containing vehicle on cat pial arteries. Stroke. 1986;17(2):225–8.

Article  CAS  PubMed  Google Scholar 

Youm JY, Park B, Park KH, Il Won Y, Byoun HS, Lim J. Vasodilatory effects of tadalafil in an animal model of cerebral vasospasm: comparative analysis with oral nimodipine. Clin Neurol Neurosurg. 2023;232: 107857.

Article  PubMed  Google Scholar 

Shubin AV, Demidyuk IV, Komissarov AA, Rafieva LM, Kostrov SV. Cytoplasmic vacuolization in cell death and survival. Oncotarget. 2016;7(34):55863–89.

Article  PubMed  PubMed Central  Google Scholar 

Yahiaoui L, Villeneuve A, Valderrama-Carvajal H, Burke F, Fixman ED. Endothelin-1 regulates proliferative responses, both alone and synergistically with PDGF, in rat tracheal smooth muscle cells. Cell Physiol Biochem. 2006;17(1–2):37–46.

Article  CAS  PubMed  Google Scholar 

Bevan JA, Bevan RD, Walters CL, Wellman T. Functional changes in human pial arteries (300 to 900 micrometer ID) within 48 hours of aneurysmal subarachnoid hemorrhage. Stroke. 1998;29(12):2575–9.

Article  CAS  PubMed  Google Scholar 

Ko Y, Totzke G, Graack GH, Heidgen FJ, Meyer zu Brickwedde MK, Düsing R, et al. Action of dihydropyridine calcium antagonists on early growth response gene expression and cell growth in vascular smooth muscle cells. J Hypertens. 1993;11(11):1171–8.

Article  CAS  PubMed  Google Scholar 

Suzuki H, Ayer R, Sugawara T, Chen W, Sozen T, Hasegawa Y, et al. Protective effects of recombinant osteopontin on early brain injury after subarachnoid hemorrhage in rats. Crit Care Med. 2010;38(2):612–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Diringer MN, Bleck TP, Claude Hemphill J 3rd, Menon D, Shutter L, Vespa P, et al. Neurocritical Care Society. Critical care management of patients following aneurysmal subarachnoid hemorrhage: recommendations from the Neurocritical Care Society’s Multidisciplinary Consensus Conference. Neurocrit Care. 2011;15(2):211–40.

Kikkawa Y, Kurogi R, Sasaki T. The single and double blood injection rabbit subarachnoid hemorrhage model. Transl Stroke Res. 2015;6(1):88–97.

Article  CAS  PubMed