Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, et al. American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics-2017 update: a report from the American Heart Association. Circulation. 2017;135(10):e146-603 (Erratum in: Circulation. 2017;135(10):e646).

Article  PubMed  PubMed Central  Google Scholar 

Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, et al. Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2019;50(12):e344-418.

Article  PubMed  Google Scholar 

Faigle R, Sharrief A, Marsh EB, Llinas RH, Urrutia VC. Predictors of critical care needs after IV thrombolysis for acute ischemic stroke. PLoS ONE. 2014;9(2):e88652.

Article  PubMed  PubMed Central  Google Scholar 

Chang A, Llinas EJ, Chen K, Llinas RH, Marsh EB. Shorter intensive care unit stays? The majority of post-intravenous tPA (tissue-type plasminogen activator) symptomatic hemorrhages occur within 12 hours of treatment. Stroke. 2018;49(6):1521–4.

Article  PubMed  Google Scholar 

Shah K, Clark A, Desai SM, Jadhav AP. Causes, predictors, and timing of early neurological deterioration and symptomatic intracranial hemorrhage after administration of IV tPA. Neurocrit Care. 2022;36(1):123–9.

Article  PubMed  Google Scholar 

Khan S, Soto A, Marsh EB. Resource allocation: stable patients remain stable 12–24 h post-tPA. Neurocrit Care. 2020;33(2):582–6.

Article  PubMed  Google Scholar 

Faigle R, Butler J, Carhuapoma JR, Johnson B, Zink EK, Shakes T, et al. Safety trial of low-intensity monitoring after thrombolysis: optimal post Tpa-Iv monitoring in ischemic stroke (OPTIMIST). Neurohospitalist. 2020;10(1):11–5.

Article  PubMed  Google Scholar 

National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995;333(24):1581–7.

Article  Google Scholar 

Hacke W, Kaste M, Fieschi C, von Kummer R, Davalos A, Meier D, et al. Second European-Australasian Acute Stroke Study Investigators. Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Lancet. 1998;352(9136):1245–51.

Article  CAS  PubMed  Google Scholar 

von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP, STROBE Initiative. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Ann Intern Med. 2007;147(8):573–7.

Article  Google Scholar 

Menon BK, Saver JL, Prabhakaran S, Reeves M, Liang L, Olson DM, et al. Risk score for intracranial hemorrhage in patients with acute ischemic stroke treated with intravenous tissue-type plasminogen activator. Stroke. 2012;43(9):2293–9.

Article  CAS  PubMed  Google Scholar 

Saposnik G, Kapral MK, Liu Y, Hall R, Odonnell M, Raptis S, Investigators of the Registry of the Canadian Stroke Network; Stroke Outcomes Research Canada (SORCan) Working Group, et al. IScore: a risk score to predict death early after hospitalization for an acute ischemic stroke. Circulation. 2011;123(7):739–49.

Article  PubMed  Google Scholar 

Li M, Wang-Qin RQ, Wang YL, Liu LB, Pan YS, Liao XL, et al. Symptomatic intracerebral hemorrhage after intravenous thrombolysis in Chinese patients: comparison of prediction models. J Stroke Cerebrovasc Dis. 2015;24(6):1235–43.

Article  PubMed  Google Scholar 

Suengtaworn A, Saposnik G, Hurst CP, Poungvarin N, Nilanont Y. Accuracy of clinical risk scores in predicting post-rtPA intracerebral hemorrhage in a Thai cohort. J Med Assoc Thai. 2019;102(5):1–7.

Google Scholar 

Wen L, Zhang S, Wan K, Zhang H, Zhang X. Risk factors of haemorrhagic transformation for acute ischaemic stroke in Chinese patients receiving intravenous thrombolysis: a meta-analysis. Med (Baltim). 2020;99(7):e18995.

Article  Google Scholar 

Honig A, Percy J, Sepehry AA, Gomez AG, Field TS, Benavente OR. Hemorrhagic transformation in acute ischemic stroke: a quantitative systematic review. J Clin Med. 2022;11(5):1162.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun J, Lam C, Christie L, Blair C, Li X, Werdiger F, et al. Risk factors of hemorrhagic transformation in acute ischaemic stroke: a systematic review and meta-analysis. Front Neurol. 2023;14:1079205.

Article  PubMed  PubMed Central  Google Scholar 

Kovács KB, Bencs V, Hudák L, Oláh L, Csiba L. Hemorrhagic transformation of ischemic strokes. Int J Mol Sci. 2023;24(18):14067.

Article  PubMed  PubMed Central  Google Scholar 

Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, Stroke Thrombolysis Trialists’ Collaborative Group, et al. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet. 2014;384(9958):1929–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chiang CC, Meyer DM, Meyer BC, Agrawal K, Modir R. Racial disparities in ICH after IV-tPA and neurointerventional treatment (RADIANT). J Stroke Cerebrovasc Dis. 2020;29(2):104474.

Article  PubMed  Google Scholar 

Roth EJ, Lovell L, Harvey RL, Heinemann AW, Semik P, Diaz S. Incidence of and risk factors for medical complications during stroke rehabilitation. Stroke. 2001;32(2):523–9.

Article  CAS  PubMed  Google Scholar 

Ouyang M, Faigle R, Wang X, Johnson B, Summers D, Khatri P, et al. The main optimal post rTpa-Iv monitoring in ischemic stroke trial (OPTIMISTmain): protocol for a pragmatic, stepped wedge, cluster randomized controlled trial. Cerebrovasc Dis. 2023. https://doi.org/10.1159/000534706.

Article  PubMed  Google Scholar 

Oliveira M, Fidalgo M, Fontão L, Antão J, Marques S, Afreixo V, et al. Tenecteplase for thrombolysis in stroke patients: systematic review with meta-analysis. Am J Emerg Med. 2021;42:31–7.

Article  CAS  PubMed  Google Scholar