Increased V-ATPase activity can lead to chemo-resistance in oral squamous cell carcinoma via autophagy induction: new insights

Norouzi A, Davodabadi F, Noorbakhsh Varnosfaderani SM, Zalpoor H. The potential role of acid ceramidase in oral squamous cell carcinoma chemo-resistance by inducing autophagy. Hum Cell. 2023. https://doi.org/10.1007/s13577-023-00960-0.

Article  PubMed  Google Scholar 

El Sheikh M. Survival and quality of life for Sudanese oral cancer patients: University College Cork; 2018.

Johnson NW, Gupta B, Speicher DJ, Ray CS, Shaikh MH, Al-Hebshi N, et al. Etiology and risk factors. Oral and oropharyngeal cancer: CRC Press; 2018. p. 19–94.

Google Scholar 

Tangsiri M, Hheidari A, Liaghat M, Razlansari M, Ebrahimi N, Akbari A, et al. Promising applications of nanotechnology in inhibiting chemo-resistance in solid tumors by targeting epithelial-mesenchymal transition (EMT). Biomed Pharmacother. 2024;170: 115973.

Article  CAS  PubMed  Google Scholar 

Chaturvedi P, Singhavi H, Malik A, Nair D. Outcome of head and neck squamous cell cancers in low-resource settings: Challenges and opportunities. Otolaryngol Clin North Am. 2018;51(3):619–29.

Article  PubMed  Google Scholar 

Saalim M, Sansare K, Karjodkar FR, Johaley S, Ali IK, Sharma SR, et al. The prevalence of oral squamous cell carcinoma with oral submucous fibrosis. J Cancer Res Ther. 2021;17(6):1510–4.

Article  PubMed  Google Scholar 

Panarese I, Aquino G, Ronchi A, Longo F, Montella M, Cozzolino I, et al. Oral and Oropharyngeal squamous cell carcinoma: prognostic and predictive parameters in the etiopathogenetic route. Expert Rev Anticancer Ther. 2019;19(2):105–19.

Article  CAS  PubMed  Google Scholar 

Zhang J, Shen Q, Ma Y, Liu L, Jia W, Chen L, et al. Calcium Homeostasis in Parkinson’s Disease: From Pathology to Treatment. Neurosci Bull. 2022;38(10):1267–1270. https://doi.org/10.1007/s12264-022-00899-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu Y, Huang R, Wu Z, Song S, Cheng L, Zhu R. Deep learning-based predictive identification of neural stem cell differentiation. Nat Commun. 2021;12(1):2614.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng Y, Li S, Gao L, Zhi K, Ren W. The molecular basis and therapeutic aspects of cisplatin resistance in oral squamous cell carcinoma. Front Oncol. 2021;11: 761379.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pan L, Feng F, Wu J, Fan S, Han J, Wang S, et al. Demethylzeylasteral targets lactate by inhibiting histone lactylation to suppress the tumorigenicity of liver cancer stem cells. Pharmacol Res. 2022;181: 106270.

Article  CAS  PubMed  Google Scholar 

Xu H, Li L, Wang S, Wang Z, Qu L, Wang C, et al. Royal jelly acid suppresses hepatocellular carcinoma tumorigenicity by inhibiting H3 histone lactylation at H3K9la and H3K14la sites. Phytomedicine. 2023:154940.

Sharma M, Astekar M, Soi S, S Manjunatha B, C Shetty D, Radhakrishnan R. pH gradient reversal: an emerging hallmark of cancers. Recent patents on anti-cancer drug discovery. 2015;10(3):244–58.

Gan Y, Xu Y, Zhang X, Hu H, Xiao W, Yu Z, et al. Revisiting Supersaturation of a Biopharmaceutical Classification System IIB Drug: Evaluation via a Multi-Cup Dissolution Approach and Molecular Dynamic Simulation. Molecules. 2023;28(19):6962.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Otero-Rey EM, Somoza-Martín M, Barros-Angueira F, García-García A. Intracellular pH regulation in oral squamous cell carcinoma is mediated by increased V-ATPase activity via over-expression of the ATP6V1C1 gene. Oral Oncol. 2008;44(2):193–9.

Article  CAS  PubMed  Google Scholar 

Eaton AF, Merkulova M, Brown D. The H+-ATPase (V-ATPase): from proton pump to signaling complex in health and disease. Am J Physiol Cell Physiol. 2021;320(3):C392–414.

Article  CAS  PubMed  Google Scholar 

Chen F, Kang R, Liu J, Tang D. The V-ATPases in cancer and cell death. Cancer Gene Ther. 2022;29(11):1529–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang A, Zhou W. Mn-based cGAS-STING activation for tumor therapy. Chin J Cancer Res. 2023;35(1):19–43. https://doi.org/10.21147/j.issn.1000-9604.2023.01.04

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao Y, Liu Y, Liu Y, Peng Y, Yuan B, Fu Y, et al. UHRF1 promotes androgen receptor-regulated CDC6 transcription and anti-androgen receptor drug resistance in prostate cancer through KDM4C-Mediated chromatin modifications. Cancer Lett. 2021;520:172–183.

Article  CAS  PubMed  Google Scholar 

Hraběta J, Belhajová M, Šubrtová H, Merlos Rodrigo MA, Heger Z, Eckschlager T. Drug sequestration in lysosomes as one of the mechanisms of chemoresistance of cancer cells and the possibilities of its inhibition. Int J Mol Sci. 2020;21(12):4392.

Article  PubMed  PubMed Central  Google Scholar 

Wang Y, Zhang L, Wei Y, Huang W, Li L, Wu A-a, et al. Pharmacological targeting of vacuolar H+-ATPase via subunit V1G combats multidrug-resistant cancer. Cell Chem Biol. 2020;27(11):1359.

Law Z-J, Khoo XH, Lim PT, Goh BH, Ming LC, Lee W-L, et al. Extracellular vesicle-mediated chemoresistance in oral squamous cell carcinoma. Front Mol Biosci. 2021;8: 629888.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kiyoshima T, Yoshida H, Wada H, Nagata K, Fujiwara H, Kihara M, et al. Chemoresistance to concanamycin A1 in human oral squamous cell carcinoma is attenuated by an HDAC inhibitor partly via suppression of Bcl-2 expression. PLoS ONE. 2013;8(11): e80998.

Article  PubMed  PubMed Central  Google Scholar 

Dong Y, Zhu G, Wang S-F, Keon KA, Rubinstein JL, Zeng S-X, et al. Toosendanin, a novel potent vacuolar-type H+-translocating ATPase inhibitor, sensitizes cancer cells to chemotherapy by blocking protective autophagy. Int J Biol Sci. 2022;18(7):2684.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Y, Mengnan Z, Benke L, Zhang B, Bing C, Yuanyuan W, et al. Ephedra Herb extract ameliorates adriamycin-induced nephrotic syndrome in rats via the CAMKK2/AMPK/mTOR signaling pathway. Chin J Nat Med. 2023;21(5):371–82.

CAS  PubMed  Google Scholar 

Kulshrestha A, Katara GK, Ibrahim SA, Riehl VE, Schneiderman S, Bilal M, et al. In vivo anti-V-ATPase antibody treatment delays ovarian tumor growth by increasing antitumor immune responses. Mol Oncol. 2020;14(10):2436–54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu L, Smith PP, Boyes SG. pH-responsive polymers for imaging acidic biological environments in tumors. J Polym Sci B Polym Phys. 2013;51:1062.

Article  CAS  Google Scholar 

de Bem PB, Nunes JS, da Silva VP, Laureano NK, Gonçalves DR, Machado IS, et al. The role of tumor acidification in aggressiveness, cell dissemination and treatment resistance of oral squamous cell carcinoma. Life Sci. 2022;288: 120163.

Article  Google Scholar 

Huber V, Camisaschi C, Berzi A, Ferro S, Lugini L, Triulzi T, et al. Cancer acidity: An ultimate frontier of tumor immune escape and a novel target of immunomodulation. Seminars Cancer Biol. 2017;43:74.

Article  CAS  Google Scholar 

Alshaker HA, Matalka KZ. IFN-γ, IL-17 and TGF-β involvement in shaping the tumor microenvironment: The significance of modulating such cytokines in treating malignant solid tumors. Cancer Cell Int. 2011;11(1):1–12.

Article  Google Scholar 

Rahat MA, Hemmerlein B. Macrophage-tumor cell interactions regulate the function of nitric oxide. Front Physiol. 2013;4:144.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mostafavi S, Zalpoor H, Hassan ZM. The promising therapeutic effects of metformin on metabolic reprogramming of cancer-associated fibroblasts in solid tumors. Cell Mol Biol Lett. 2022;27(1):1–24.

Article  Google Scholar 

Pilon-Thomas S, Kodumudi KN, El-Kenawi AE, Russell S, Weber AM, Luddy K, et al. Neutralization of tumor acidity improves antitumor responses to immunotherapy. Can Res. 2016;76(6):1381–90.

Article  CAS  Google Scholar 

Tong L, Yue P, Yang Y, Huang J, Zeng Z, Qiu W. Motility and mechanical properties of dendritic cells deteriorated by extracellular acidosis. Inflammation. 2021;44:737–45.

Article  CAS  PubMed  Google Scholar 

Worsley CM, Veale RB, Mayne ES. The acidic tumour microenvironment: Manipulating the immune response to elicit escape. Hum Immunol. 2022;83(5):399–408.

Article  CAS  PubMed  Google Scholar 

Cao J, Chen C, Wang Y, Chen X, Chen Z, Luo X. Influence of autologous dendritic cells on cytokine-induced killer cell proliferation, cell phenotype and antitumor activity in vitro. Oncol Lett. 2016;12(3):2033–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen L, He Y, Zhu J, Zhao S, Qi S, Chen X, et al. The roles and mechanism of m6A RNA methylation regulators in cancer immunity. Biomed Pharmacother. 2023;163: 114839.

Article  CAS  PubMed  Google Scholar 

Lv C, Yang X, Yu B, Ma Q, Liu B, Liu Y. Blocking the Na+/H+ exchanger 1 with cariporide (HOE642) reduces the hypoxia-induced invasion of human tongue squamous cell carcinoma. Int J Oral Maxillofac Surg. 2012;41(10):1206–10.

Article  CAS  PubMed  Google Scholar 

Zhou J, Guo T, Zhou L, Bao M, Wang L, Zhou W, et al. The ferroptosis signature predicts the prognosis and immune microenvironment of nasopharyngeal carcinoma. Sci Rep. 2023;13(1):1861.

Article  CAS  PubMed  PubMed Central 

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