Krupinski, J. et al. Adenylyl cyclase amino acid sequence: possible channel- or transporter-like structure. Science 244, 1558–1564 (1989).
Article CAS PubMed Google Scholar
Baldwin, T. A., Li, Y., Brand, C. S., Watts, V. J. & Dessauer, C. W. Insights into the regulatory properties of human adenylyl cyclase type 9. Mol. Pharmacol. 95, 349–360 (2019).
Article CAS PubMed PubMed Central Google Scholar
Ostrom, K. F. et al. Physiological roles of mammalian transmembrane adenylyl cyclase isoforms. Physiol. Rev. 102, 815–857 (2022).
Article CAS PubMed Google Scholar
Crossthwaite, A. J. et al. The cytosolic domains of Ca2+-sensitive adenylyl cyclases dictate their targeting to plasma membrane lipid rafts. J. Biol. Chem. 280, 6380–6391 (2005).
Article CAS PubMed Google Scholar
Gu, C. & Cooper, D. M. Calmodulin-binding sites on adenylyl cyclase type VIII. J. Biol. Chem. 274, 8012–8021 (1999).
Article CAS PubMed Google Scholar
Brand, C. S., Sadana, R., Malik, S., Smrcka, A. V. & Dessauer, C. W. Adenylyl cyclase 5 regulation by Gβγ involves isoform-specific use of multiple interaction sites. Mol. Pharmacol. 88, 758–767 (2015).
Article CAS PubMed PubMed Central Google Scholar
Tesmer, J. J., Sunahara, R. K., Gilman, A. G. & Sprang, S. R. Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS. Science 278, 1907–1916 (1997).
Article CAS PubMed Google Scholar
Qi, C., Sorrentino, S., Medalia, O. & Korkhov, V. M. The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein. Science 364, 389–394 (2019).
Article CAS PubMed Google Scholar
Ma, X., Beuve, A. & van den Akker, F. Crystal structure of the signaling helix coiled-coil domain of the beta1 subunit of the soluble guanylyl cyclase. BMC Struct. Biol. 10, 2 (2010).
Article PubMed PubMed Central Google Scholar
Dessauer, C. W. Adenylyl cyclase–A-kinase anchoring protein complexes: the next dimension in cAMP signaling. Mol. Pharmacol. 76, 935–941 (2009).
Article CAS PubMed PubMed Central Google Scholar
Vatner, S. F. et al. Adenylyl cyclase type 5 in cardiac disease, metabolism, and aging. Am. J. Physiol. Heart Circ. Physiol. 305, H1–H8 (2013).
Article CAS PubMed PubMed Central Google Scholar
Chen, D. H. et al. ADCY5-related dyskinesia: broader spectrum and genotype-phenotype correlations. Neurology 85, 2026–2035 (2015).
Article CAS PubMed PubMed Central Google Scholar
Chen, Y. Z. et al. Gain-of-function ADCY5 mutations in familial dyskinesia with facial myokymia. Ann. Neurol. 75, 542–549 (2014).
Article CAS PubMed PubMed Central Google Scholar
Weichsel, A., Kievenaar, J. A., Curry, R., Croft, J. T. & Montfort, W. R. Instability in a coiled-coil signaling helix is conserved for signal transduction in soluble guanylyl cyclase. Protein Sci. 28, 1830–1839 (2019).
Article CAS PubMed PubMed Central Google Scholar
Gao, X., Sadana, R., Dessauer, C. W. & Patel, T. B. Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits. J. Biol. Chem. 282, 294–302 (2007).
Article CAS PubMed Google Scholar
Jumper, J. et al. Highly accurate protein structure prediction with AlphaFold. Nature 596, 583–589 (2021).
Article CAS PubMed PubMed Central Google Scholar
Ren, J. et al. CSS-Palm 2.0: an updated software for palmitoylation sites prediction. Protein Eng. Des. Sel. 21, 639–644 (2008).
Article CAS PubMed PubMed Central Google Scholar
Bauman, A. L. et al. Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes. Mol. Cell 23, 925–931 (2006).
Article CAS PubMed PubMed Central Google Scholar
Evans, R. et al. Protein complex prediction with AlphaFold-Multimer. Preprint at bioRxiv https://doi.org/10.1101/2021.10.04.463034 (2022).
Lambright, D. G. et al. The 2.0 Å crystal structure of a heterotrimeric G protein. Nature 379, 311–319 (1996).
Article CAS PubMed Google Scholar
Lodowski, D. T., Pitcher, J. A., Capel, W. D., Lefkowitz, R. J. & Tesmer, J. J. Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma. Science 300, 1256–1262 (2003).
Article CAS PubMed Google Scholar
Cash, J. N. et al. Cryo-electron microscopy structure and analysis of the P-Rex1-Gβγ signaling scaffold. Sci. Adv. 5, eaax8855 (2019).
Article CAS PubMed PubMed Central Google Scholar
Doyle, T. B., Hayes, M. P., Chen, D. H., Raskind, W. H. & Watts, V. J. Functional characterization of AC5 gain-of-function variants: Impact on the molecular basis of ADCY5-related dyskinesia. Biochem. Pharmacol. 163, 169–177 (2019).
Article CAS PubMed PubMed Central Google Scholar
Soto-Velasquez, M., Hayes, M. P., Alpsoy, A., Dykhuizen, E. C. & Watts, V. J. A novel CRISPR/Cas9-based cellular model to explore adenylyl cyclase and cAMP signaling. Mol. Pharmacol. 94, 963–972 (2018).
Article CAS PubMed PubMed Central Google Scholar
Rees, S. D. et al. Effects of 16 genetic variants on fasting glucose and type 2 diabetes in South Asians: ADCY5 and GLIS3 variants may predispose to type 2 diabetes. PLoS ONE 6, e24710 (2011).
Article CAS PubMed PubMed Central Google Scholar
Knigge, A. et al. ADCY5 gene expression in adipose tissue is related to obesity in men and mice. PLoS ONE 10, e0120742 (2015).
Article PubMed PubMed Central Google Scholar
Ferrini, A., Steel, D., Barwick, K. & Kurian, M. A. An update on the phenotype, genotype and neurobiology of ADCY5-related disease. Mov. Disord. 36, 1104–1114 (2021).
Article CAS PubMed Google Scholar
Westenberger, A. et al. Alternating hemiplegia of childhood as a new presentation of adenylate cyclase 5-mutation-associated disease: a report of two cases. J. Pediatr. 181, 306–308.e1 (2017).
Dean, M. et al. Child neurology: spastic paraparesis and dystonia with a novel ADCY5 mutation. Neurology 93, 510–514 (2019).
Article PubMed PubMed Central Google Scholar
Fagan, K. A., Smith, K. E. & Cooper, D. M. Regulation of the Ca2+-inhibitable adenylyl cyclase type VI by capacitative Ca2+ entry requires localization in cholesterol-rich domains. J. Biol. Chem. 275, 26530 (2000).
Article CAS PubMed Google Scholar
Ostrom, R. S. et al. Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts. J. Biol. Chem. 278, 24461–24468 (2003).
Article CAS PubMed Google Scholar
Weitmann, S., Schultz, G. & Kleuss, C. Adenylyl cyclase type II domains involved in Gbetagamma stimulation. Biochemistry 40, 10853–10858 (2001).
Article CAS PubMed Google Scholar
Diel, S., Klass, K., Wittig, B. & Kleuss, C. Gbetagamma activation site in adenylyl cyclase type II. Adenylyl cyclase type III is inhibited by Gbetagamma. J. Biol. Chem. 281, 288–294 (2006).
Article CAS PubMed Google Scholar
Chen, J. et al. A region of adenylyl cyclase 2 critical for regulation by G protein beta gamma subunits. Science 268, 1166–1169 (1995).
Article CAS PubMed Google Scholar
Diel, S., Beyermann, M., Lloréns, J. M., Wittig, B. & Kleuss, C. Two interaction sites on mammalian adenylyl cyclase type I and II: modulation by calmodulin and G(betagamma). Biochem. J. 411, 449–456 (2008).
Article CAS PubMed Google Scholar
Boran, A. D., Chen, Y. & Iyengar, R. Identification of new Gβγ interaction sites in adenylyl cyclase 2. Cell Signal 23, 1489–1495 (2011).
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