WHO Coronavirus (COVID-19) https://covid19.who.int

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•• Sudhakar M, Winfred SB, Meiyazhagan G, Venkatachalam DP. Mechanisms contributing to adverse outcomes of COVID-19 in obesity. Mol Cell Biochem. 2022;477(4):1155–93. This review has examined the available literature on the underlying mechanisms contributing to obesity being a risk for adverse outcome in COVID-19.

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Maurya R, Sebastian P, Namdeo M, Devender M, Gertler A. COVID-19 severity in obesity: leptin and inflammatory cytokine interplay in the link between high morbidity and mortality. Front Immunol. 2021;12:649359.

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Al-Benna S. Association of high level gene expression of ACE2 in adipose tissue with mortality of COVID-19 infection in obese patients. Obes Med sept. 2020;19:100283.

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• Reddy MP, Subramaniam A, Chua C, Ling RR, Anstey C, Ramanathan K, et al. Respiratory system mechanics, gas exchange, and outcomes in mechanically ventilated patients with COVID-19-related acute respiratory distress syndrome: a systematic review and meta-analysis. Lancet Respir Med déc. 2022;10(12):1178–88. This article showed the absence of evidence of distinct phenotypes in patients with COVID-19-related ARDS.

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Simonnet A, Chetboun M, Poissy J, Raverdy V, Noulette J, Duhamel A, et al. High prevalence of obesity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation. Obes Silver Spring Md juill. 2020;28(7):1195–9.

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Zdravković V, Stevanović Đ, Ćićarić N, Zdravković N, Čekerevac I, Poskurica M, et al. Anthropometric measurements and admission parameters as predictors of acute respiratory distress syndrome in hospitalized COVID-19 patients. Biomedicines. 2023;11(4):1199.

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• Li Y, Li C, Chang W, Liu L. High-flow nasal cannula reduces intubation rate in patients with COVID-19 with acute respiratory failure: a meta-analysis and systematic review. BMJ Open. 2023;13(3):e067879. This study showed that HFNC may reduce intubation rate and 28-day ICU mortality in patients with acute respiratory failure.

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•• Thille AW, Coudroy R, Nay MA, Gacouin A, Decavèle M, Sonneville R, et al. Beneficial effects of noninvasive ventilation after extubation in obese or overweight patients: a post hoc analysis of a randomized clinical trial. Am J Respir Crit Care Med. 2022;205(4):440–9 This article showed the benefit of NIV in obese patients as a new strategy after extubation in obese patients.

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Silver SA, Beaubien-Souligny W, Shah PS, Harel S, Blum D, Kishibe T, et al. The prevalence of acute kidney injury in patients hospitalized with COVID-19 infection: a systematic review and meta-analysis. Kidney Med févr. 2021;3(1):83–98.e1.

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Moledina DG, Simonov M, Yamamoto Y, Alausa J, Arora T, Biswas A, et al. The association of COVID-19 with acute kidney injury independent of severity of illness: a multicenter cohort study. Am J Kidney Dis Off J Natl Kidney Found. 2021;77(4):490–499.e1.

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Yang J, Ma Z, Lei Y. A meta-analysis of the association between obesity and COVID-19. Epidemiol Infect. 2020;149.

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Zhao X, Gang X, He G, Li Z, Lv Y, Han Q, et al. Obesity increases the severity and mortality of influenza and COVID-19: a systematic review and meta-analysis. Front Endocrinol. 2020;11:595109.

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•• Kooistra EJ, Brinkman S, van der Voort PHJ, de Keizer NF, Dongelmans DA, Kox M, et al. Body mass index and mortality in coronavirus disease 2019 and other diseases: a cohort study in 35,506 ICU patients. Crit Care Med janv. 2022;50(1):e1-10 This study showed the absence of an obesity paradox in ICU patients with COVID-19 in contrast to nonsevere acute respiratory syndrome coronavirus 2 viral and bacterial respiratory infections.

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