Kumar N, Singh A. Trends of male factor infertility, an important cause of infertility: a review of literature. J Hum Reprod Sci. 2015;8:191–6. https://doi.org/10.4103/0974-1208.170370.

Article  PubMed  PubMed Central  Google Scholar 

Ozkocer SE, Konac E. The current perspective on genetic and epigenetic factors in sperm maturation in the epididymis. Andrologia. 2021;53(3):e13989. https://doi.org/10.1111/and.13989.

Agarwal A, Mulgund A, Hamada A, Chyatte MR. A unique view on male infertility around the globe. Reprod Biol Endocrinol. 2015. https://doi.org/10.1186/S12958-015-0032-1.

Article  PubMed  PubMed Central  Google Scholar 

Levine H, Jørgensen N, Martino-Andrade A, Mendiola J, Weksler-Derri D, Jolles M, et al. Temporal trends in sperm count: a systematic review and meta-regression analysis of samples collected globally in the 20th and 21st centuries. Hum Reprod Update. 2023;29:157–76. https://doi.org/10.1093/humupd/dmac035.

Article  PubMed  Google Scholar 

Benatta M, Kettache R, Buchholz N, Trinchieri A. The impact of nutrition and lifestyle on male fertility. Arch Ital di Urol e Androl. 2020;92:121–31. https://doi.org/10.4081/aiua.2020.2.121.

Article  Google Scholar 

Salas-Huetos A, James ER, Aston KI, Jenkins TG, Carrell DT. Diet and sperm quality: nutrients, foods and dietary patterns. Reprod Biol. 2019;19:219–24. https://doi.org/10.1016/J.REPBIO.2019.07.005.

Article  PubMed  Google Scholar 

Mintziori G, Nigdelis MP, Mathew H, Mousiolis A, Goulis DG, Mantzoros CS. The effect of excess body fat on female and male reproduction. Metabolism. 2020. https://doi.org/10.1016/j.metabol.2020.154193.

Article  PubMed  Google Scholar 

Sermondade N, Faure C, Fezeu L, Shayeb AG, Bonde JP, Jensen TK, et al. BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. Hum Reprod Update. 2013;19:221. https://doi.org/10.1093/HUMUPD/DMS050.

Article  CAS  PubMed  Google Scholar 

Zhu L, Zhou B, Zhu X, Cheng F, Pan Y, Zhou Y, et al. Association between body mass index and female infertility in the United States: data from National Health and Nutrition Examination Survey 2013–2018. Int J Gen Med. 2022;15:1821–31. https://doi.org/10.2147/IJGM.S349874.

Article  PubMed  PubMed Central  Google Scholar 

Hernáez Á, Rogne T, Skåra KH, Håberg SE, Page CM, Fraser A, et al. Body mass index and subfertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study. Hum Reprod. 2021;36:3141–51. https://doi.org/10.1093/HUMREP/DEAB224.

Article  PubMed  PubMed Central  Google Scholar 

Lan L, Harrison CL, Misso M, Hill B, Teede HJ, Mol BW, et al. Systematic review and meta-analysis of the impact of preconception lifestyle interventions on fertility, obstetric, fetal, anthropometric and metabolic outcomes in men and women. Hum Reprod. 2017;32:1925–40. https://doi.org/10.1093/humrep/dex241.

Article  CAS  PubMed  Google Scholar 

Fabozzi G, Verdone G, Allori M, Cimadomo D, Tatone C, Stuppia L, et al. Personalized nutrition in the management of female infertility: new insights on chronic low-grade inflammation. Nutr. 1918;2022:14. https://doi.org/10.3390/NU14091918.

Article  Google Scholar 

Soliman GA. Intermittent fasting and time-restricted eating role in dietary interventions and precision nutrition. Front Public Heal. 2022. https://doi.org/10.3389/fpubh.2022.1017254.

Article  Google Scholar 

Golbidi S, Daiber A, Korac B, Li H, Essop MF, Laher I. Health benefits of fasting and caloric restriction. Curr Diab Rep. 2017;17:1–11. https://doi.org/10.1007/s11892-017-0951-7.

Article  CAS  Google Scholar 

Cena H, Calder PC. Defining a healthy diet: evidence for the role of contemporary dietary patterns in health and disease. Nutrients. 2020. https://doi.org/10.3390/NU12020334.

Article  PubMed  PubMed Central  Google Scholar 

Napoleão A, Fernandes L, Miranda C, Marum AP. Effects of calorie restriction on health span and insulin resistance: classic calorie restriction diet vs. ketosis-inducing diet. Nutrients. 2021. https://doi.org/10.3390/NU13041302.

Article  PubMed  PubMed Central  Google Scholar 

Sergeeva E, Ruksha T, Fefelova Y. Effects of obesity and calorie restriction on cancer development. Int J Mol Sci. 2023. https://doi.org/10.3390/IJMS24119601.

Article  PubMed  PubMed Central  Google Scholar 

Most J, Tosti V, Redman LM, Fontana L. Calorie restriction in humans: an update. Ageing Res Rev. 2017;39:36. https://doi.org/10.1016/J.ARR.2016.08.005.

Article  PubMed  Google Scholar 

Shukla AP, Buniak WI, Aronne LJ. Treatment of obesity in 2015. J Cardiopulm Rehabil Prev. 2015;35(2):81–92. https://doi.org/10.1097/HCR.0000000000000112.

Article  PubMed  Google Scholar 

Colman RJ, Beasley TM, Kemnitz JW, Johnson SC, Weindruch R, Anderson RM. Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys. Nat Commun. 2014;5:1–5. https://doi.org/10.1038/ncomms4557.

Article  CAS  Google Scholar 

Mattison JA, Roth GS, Mark Beasley T, Tilmont EM, Handy AM, Herbert RL, et al. Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature. 2012;489:318–21. https://doi.org/10.1038/nature11432.

Article  CAS  PubMed  Google Scholar 

Mattison JA, Colman RJ, Beasley TM, Allison DB, Kemnitz JW, Roth GS, et al. Caloric restriction improves health and survival of rhesus monkeys. Nat Commun. 2017. https://doi.org/10.1038/ncomms14063.

Article  PubMed  PubMed Central  Google Scholar 

Hernández-Saavedra D, Moody L, Xu GB, Chen H, Pan Y-X. Epigenetic regulation of metabolism and inflammation by calorie restriction. Adv Nutr. 2019;10:520–36. https://doi.org/10.1093/advances/nmy129.

Article  PubMed  PubMed Central  Google Scholar 

Maugeri A. The effects of dietary interventions on dna methylation: Implications for obesity management. Int J Mol Sci. 2020;21:1–17. https://doi.org/10.3390/ijms21228670.

Article  CAS  Google Scholar 

Milagro FI, Campión J, Cordero P, Goyenechea E, GGómez‐Uriz AM, Abete I, et al. A dual epigenomic approach for the search of obesity biomarkers DNA methylation in relation to diet-induced weight loss PubMed. FASEB J. 2011;25:1378–89. https://doi.org/10.1096/FJ.10-170365.

Article  CAS  PubMed  Google Scholar 

Ye X, Li M, Hou T, Gao T. Zhu W guo, Yang Y Sirtuins in glucose and lipid metabolism. Oncotarget. 2017;8:1845–59. https://doi.org/10.18632/oncotarget.12157.

Article  PubMed  Google Scholar 

Liu Q, Ding C, Lang X, Guo G, Chen J, Su X. Small noncoding RNA discovery and profiling with sRNAtools based on high-throughput sequencing. Brief Bioinform. 2021;22:463–73. https://doi.org/10.1093/bib/bbz151.

Article  CAS  PubMed  Google Scholar 

Dhahbi JM, Spindler SR, Atamna H, Yamakawa A, Guerrero N, Boffelli D, et al. Deep sequencing identifies circulating mouse miRNAs that are functionally implicated in manifestations of aging and responsive to calorie restriction. Aging (Albany NY). 2013;5:130–41. https://doi.org/10.18632/aging.100540.

Article  CAS  PubMed  Google Scholar 

Makwana K, Patel SA, Velingkaar N, Ebron JS, Shukla GC, Kondratov RV. Aging and calorie restriction regulate the expression of miR-125a-5p and its target genes Stat3 Casp2 and Stard13. Aging (Albany NY). 2017;9:1825–43. https://doi.org/10.18632/aging.101270.

Article  CAS  PubMed  Google Scholar 

Olivo-Marston SE, Hursting SD, Perkins SN, Schetter A, Khan M, Croce C, et al. Effects of calorie restriction and diet-induced obesity on murine colon carcinogenesis, growth and inflammatory factors, and microRNA expression. PLoS One. 2014. https://doi.org/10.1371/JOURNAL.PONE.0094765.

Article  PubMed  PubMed Central  Google Scholar 

Procaccini C, de Candia P, Russo C, De Rosa G, Lepore MT, Colamatteo A, et al. Caloric restriction for the immunometabolic control of human health. Cardiovasc Res. 2023. https://doi.org/10.1093/CVR/CVAD035.

Article  Google Scholar 

Hofer SJ, Carmona-Gutierrez D, Mueller MI, Madeo F, Carmona-Gutierrez D, Mueller MI, et al. The ups and downs of caloric restriction and fasting: from molecular effects to clinical application. EMBO Mol Med. 2022;14:e14418. https://doi.org/10.15252/EMMM.202114418. Nutrition has shown promise in extending life- and health-span and mitigating diseases. Alternative diet interventions have potential and risk highlighting for clinical applications.

Kopeina GS, Senichkin VV, Zhivotovsky B. Caloric restriction - a promising anti-cancer approach: from molecular mechanisms to clinical trials. Biochim Biophys Acta - Rev Cancer. 2017;1867:29–41.

Article  CAS  PubMed  Google Scholar 

Zou H, Wang D, Ren H, Cai K, Chen P, Fang C, et al. Effect of caloric restriction on BMI, gut microbiota, and blood amino acid levels in non-obese adults. Nutrients. 2020. https://doi.org/10.3390/NU12030631.

Article  PubMed  PubMed Central  Google Scholar 

Spadaro O, Youm Y, Shchukina I, Ryu S, Sidorov S, Ravussin A, et al. Caloric restriction in humans reveals immunometabolic regulators of health span. Science (80- ). 2022;375:671–7. https://doi.org/10.1126/science.abg7292.

Article  CAS  Google Scholar 

Speakman JR, Mitchell SE. Caloric restriction. Mol Aspects Med. 2011;32:159–221.

Article  CAS  PubMed  Google Scholar 

Willett WC, Stampfer MJ. Current evidence on healthy eating. Annu Rev Public Health. 2013. https://doi.org/10.1146/annurev-publhealth-031811-124646.

Article  PubMed