Kylhammar, D. et al. A comprehensive risk stratification at early follow-up determines prognosis in pulmonary arterial hypertension. Eur. Heart J. 39, 4175–4181 (2018).
Frost, A. et al. Diagnosis of pulmonary hypertension. Eur. Respir. J. 53, https://doi.org/10.1183/13993003.01904-2018 (2019).
Hassoun, P. M. & Taichman, D. B. Pulmonary arterial hypertension. N. Engl. J. Med. 385, 2361–2376 (2021).
Article CAS PubMed Google Scholar
Humbert, M. et al. Sotatercept for the treatment of pulmonary arterial hypertension. N. Engl. J. Med. 384, 1204–1215 (2021).
Article CAS PubMed Google Scholar
Chen, J. et al. Microbiome and metabolome dysbiosis of the gut-lung axis in pulmonary hypertension. Microbiol. Res. 265, 127205 (2022).
Chen, Y. H., Yuan, W., Meng, L. K., Zhong, J. C. & Liu, X. Y. The role and mechanism of gut microbiota in pulmonary arterial hypertension. Nutrients 14, https://doi.org/10.3390/nu14204278 (2022).
Huang, L., Zhang, H., Liu, Y. & Long, Y. The role of gut and airway microbiota in pulmonary arterial hypertension. Front Microbiol. 13, 929752 (2022).
Article PubMed PubMed Central Google Scholar
Oliveira, S. D. Insights on the gut-mesentery-lung axis in pulmonary arterial hypertension: a poorly investigated crossroad. Arterioscler. Thromb. Vasc. Biol. 42, 516–526 (2022).
Article CAS PubMed PubMed Central Google Scholar
Wu, P., Zhu, T., Tan, Z., Chen, S. & Fang, Z. Role of gut microbiota in pulmonary arterial hypertension. Front Cell Infect. Microbiol. 12, 812303 (2022).
Article CAS PubMed PubMed Central Google Scholar
Zhang, C. et al. Altered airway microbiota composition in patients with pulmonary hypertension. Hypertension 76, 1589–1599 (2020).
Article CAS PubMed Google Scholar
Kim, S. et al. Altered gut microbiome profile in patients with pulmonary arterial hypertension. Hypertension 75, 1063–1071 (2020).
Article CAS PubMed Google Scholar
Karoor, V. et al. The short-chain fatty acid butyrate attenuates pulmonary vascular remodeling and inflammation in hypoxia-induced pulmonary hypertension. Int. J. Mol. Sci. 22, https://doi.org/10.3390/ijms22189916 (2021).
Huang, Y. et al. Gut microbial metabolite trimethylamine N-oxide aggravates pulmonary hypertension. Am. J. Respir. Cell Mol. Biol. 66, 452–460 (2022).
Article CAS PubMed Google Scholar
Moutsoglou, D. M. et al. Pulmonary arterial hypertension patients have a proinflammatory gut microbiome and altered circulating microbial metabolites. Am. J. Respir. Crit. Care Med. 207, 740–756 (2023).
Article CAS PubMed Google Scholar
Sanada, T. J. et al. Gut microbiota modification suppresses the development of pulmonary arterial hypertension in an SU5416/hypoxia rat model. Pulmonary Circ. 10, 2045894020929147–2045894020929147 (2020).
Gaeckle, N. T., Pragman, A. A., Pendleton, K. M., Baldomero, A. K. & Criner, G. J. The oral-lung axis: the impact of oral health on lung health. Respir Care 65, 1211–1220 (2020).
Dong, J. et al. Relationships between oral microecosystem and respiratory diseases. Front Mol. Biosci. 8, 718222 (2021).
Article CAS PubMed Google Scholar
Segal, L. N. et al. Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype. Nat. Microbiol. 1, 16031 (2016).
Article CAS PubMed PubMed Central Google Scholar
Mammen, M. J., Scannapieco, F. A. & Sethi, S. Oral-lung microbiome interactions in lung diseases. Periodontol 2000 83, 234–241 (2020).
Pu, C. Y., Seshadri, M., Manuballa, S. & Yendamuri, S. The Oral Microbiome and Lung Diseases. Current Oral Health Reports 7, 79–86 (2020).
Hajishengallis, G. Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications. Periodontol 2000 89, 9–18 (2022).
Article PubMed PubMed Central Google Scholar
Hajishengallis, G. & Chavakis, T. Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities. Nat Rev Immunol, 1-15, (2021).
Dorfmüller, P., Perros, F., Balabanian, K. & Humbert, M. Inflammation in pulmonary arterial hypertension. European Respiratory Journal 22, 358 (2003).
Schermuly, R. T., Ghofrani, H. A., Wilkins, M. R. & Grimminger, F. Mechanisms of disease: pulmonary arterial hypertension. Nat Rev Cardiol 8, 443–455 (2011).
Article CAS PubMed PubMed Central Google Scholar
Wang, R.-R. et al. Immunity and inflammation in pulmonary arterial hypertension: From pathophysiology mechanisms to treatment perspective. Pharmacological Research 180, 106238 (2022).
Article CAS PubMed Google Scholar
Rabinovitch, M., Guignabert, C., Humbert, M. & Nicolls, M. R. Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension. Circ Res. 115, 165–175 (2014).
Article CAS PubMed PubMed Central Google Scholar
Ryan, J. J. & Archer, S. L. The right ventricle in pulmonary arterial hypertension: disorders of metabolism, angiogenesis and adrenergic signaling in right ventricular failure. Circ Res. 115, 176–188 (2014).
Article CAS PubMed PubMed Central Google Scholar
Tuder, R. M., Groves, B., Badesch, D. B. & Voelkel, N. F. Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension. Am. J. Pathol. 144, 275–285 (1994).
CAS PubMed PubMed Central Google Scholar
Cool, C. D., Kennedy, D., Voelkel, N. F. & Tuder, R. M. Pathogenesis and evolution of plexiform lesions in pulmonary hypertension associated with scleroderma and human immunodeficiency virus infection. Hum. Pathol. 28, 434–442 (1997).
Article CAS PubMed Google Scholar
Zhang, J. et al. Differential oral microbial input determines two microbiota pneumo-types associated with health status. Adv. Sci. (Weinh) 9, e2203115 (2022).
Sanz, M. et al. Periodontitis and cardiovascular diseases: consensus report. J. Clin. Periodontol. 47, 268–288 (2020).
Article PubMed PubMed Central Google Scholar
Herrera, D. et al. Association between periodontal diseases and cardiovascular diseases, diabetes and respiratory diseases: Consensus report of the Joint Workshop by the European Federation of Periodontology (EFP) and the European arm of the World Organization of Family Doctors (WONCA Europe). J. Clin. Periodontol. 50, 819–841 (2023).
Article CAS PubMed Google Scholar
Czesnikiewicz-Guzik, M. et al. Causal association between periodontitis and hypertension: evidence from Mendelian randomization and a randomized controlled trial of non-surgical periodontal therapy. Eur. Heart J. 40, 3459–3470 (2019).
Article PubMed PubMed Central Google Scholar
Chen, B.-Y. et al. Roles of oral microbiota and oral-gut microbial transmission in hypertension. J. Adv. Res. 43, 147–161 (2023).
Article CAS PubMed Google Scholar
Hajishengallis, G. Periodontitis: from microbial immune subversion to systemic inflammation. Nat. Rev. Immunol. 15, 30–44 (2015).
Article CAS PubMed PubMed Central Google Scholar
Lourenςo, T. G. B., Spencer, S. J., Alm, E. J. & Colombo, A. P. V. Defining the gut microbiota in individuals with periodontal diseases: an exploratory study. J. Oral Microbiol. 10, 1487741 (2018).
Article PubMed PubMed Central Google Scholar
Kitamoto, S. et al. The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis. Cell, https://doi.org/10.1016/j.cell.2020.05.048 (2020).
Bui, F. Q. et al. Association between periodontal pathogens and systemic disease. Biomed. J. 42, 27–35 (2019).
Article PubMed PubMed Central Google Scholar
Shen, X. et al. Ectopic colonization and immune landscapes of periodontitis microbiota in germ-free mice with streptozotocin-induced type 1 diabetes mellitus. Front. Microbiol. 13, https://doi.org/10.3389/fmicb.2022.889415 (2022).
Atarashi, K. et al. Ectopic colonization of oral bacteria in the intestine drives T(H)1 cell induction and inflammation. Science 358, 359–365 (2017).
Article CAS PubMed PubMed Central Google Scholar
Blasco-Baque, V. et al. Periodontitis induced by Porphyromonas gingivalis drives periodontal microbiota dysbiosis and insulin resistance via an impaired adaptive immune response. Gut. 66, 872–885 (2017).
Article CAS PubMed Google Scholar
Zhang, C. et al. Airway delivery of Streptococcus salivarius is sufficient to induce experimental pulmonary hypertension in rats. Br. J. Pharmacol. 180, 2102–2119 (2023).
留言 (0)