Differences between cultured astrocytes from neonatal and adult Wistar rats: focus on in vitro aging experimental models

Bellaver B, Souza DG, Bobermin LD et al (2015) Resveratrol protects hippocampal astrocytes against LPS-induced neurotoxicity through HO-1, p38 and ERK pathways. Neurochem Res 40:1600–1608. https://doi.org/10.1007/s11064-015-1636-8

Article  CAS  PubMed  Google Scholar 

Bellaver B, Souza DG, Souza DO, Quincozes-Santos A (2017) Hippocampal astrocyte cultures from adult and aged rats reproduce changes in glial functionality observed in the aging brain. Mol Neurobiol 54:2969–2985. https://doi.org/10.1007/s12035-016-9880-8

Article  CAS  PubMed  Google Scholar 

Bobermin LD, de Souza Almeida RR, Weber FB et al (2022) Lipopolysaccharide induces gliotoxicity in hippocampal astrocytes from aged rats: insights about the glioprotective roles of resveratrol. Mol Neurobiol. https://doi.org/10.1007/s12035-021-02664-8

Article  PubMed  Google Scholar 

Bobermin LD, Roppa RHA, Gonçalves C-A, Quincozes-Santos A (2020) Ammonia-induced glial-inflammaging. Mol Neurobiol 57:3552–3567. https://doi.org/10.1007/s12035-020-01985-4

Article  CAS  PubMed  Google Scholar 

Bobermin LD, Roppa RHA, Quincozes-Santos A (2019) Adenosine receptors as a new target for resveratrol-mediated glioprotection. Biochim Biophys Acta Mol Basis Dis 1865:634–647. https://doi.org/10.1016/j.bbadis.2019.01.004

Article  CAS  PubMed  Google Scholar 

Browne RW, Armstrong D (1998) Reduced glutathione and glutathione disulfide. In: Free radical and antioxidant protocols. Humana Press, New Jersey, pp 347–352. https://doi.org/10.1385/0-89603-472-0:347

Cao P, Zhang J, Huang Y et al (2019) The age-related changes and differences in energy metabolism and glutamate-glutamine recycling in the d-gal-induced and naturally occurring senescent astrocytes in vitro. Exp Gerontol 118:9–18. https://doi.org/10.1016/j.exger.2018.12.018

Article  CAS  PubMed  Google Scholar 

Chen Z, Yuan Z, Yang S et al (2023) Brain Energy metabolism: astrocytes in neurodegenerative diseases. CNS Neurosci Ther 29:24–36. https://doi.org/10.1111/cns.13982

Article  CAS  PubMed  Google Scholar 

Cheung G, Bataveljic D, Visser J et al (2022) Physiological synaptic activity and recognition memory require astroglial glutamine. Nat Commun 13:753. https://doi.org/10.1038/s41467-022-28331-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Clarke LE, Liddelow SA, Chakraborty C et al (2018) Normal aging induces A1-like astrocyte reactivity. Proc Natl Acad Sci USA 115:E1896–E1905. https://doi.org/10.1073/pnas.1800165115

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cunnane SC, Trushina E, Morland C et al (2020) Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing. Nat Rev Drug Discov 19:609–633. https://doi.org/10.1038/s41573-020-0072-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Currais A, Maher P (2013) Functional consequences of age-dependent changes in glutathione status in the brain. Antioxid Redox Signal 19:813–822. https://doi.org/10.1089/ars.2012.4996

Article  CAS  PubMed  Google Scholar 

Danbolt NC (2001) Glutamate uptake. Prog Neurobiol 65:1–105. https://doi.org/10.1016/S0301-0082(00)00067-8

Article  CAS  PubMed  Google Scholar 

dos Santos AQ, Nardin P, Funchal C et al (2006) Resveratrol increases glutamate uptake and glutamine synthetase activity in C6 glioma cells. Arch Biochem Biophys 453:161–167. https://doi.org/10.1016/j.abb.2006.06.025

Article  CAS  PubMed  Google Scholar 

Escartin C, Galea E, Lakatos A et al (2021) Reactive astrocyte nomenclature, definitions, and future directions. Nat Neurosci 24:312–325. https://doi.org/10.1038/s41593-020-00783-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Franceschi C, Garagnani P, Parini P et al (2018) Inflammaging: a new immune–metabolic viewpoint for age-related diseases. Nat Rev Endocrinol 14:576–590. https://doi.org/10.1038/s41574-018-0059-4

Article  CAS  PubMed  Google Scholar 

Frieg B, Görg B, Gohlke H, Häussinger D (2021) Glutamine synthetase as a central element in hepatic glutamine and ammonia metabolism: novel aspects. Biol Chem 402:1063–1072. https://doi.org/10.1515/hsz-2021-0166

Article  CAS  PubMed  Google Scholar 

Gonçalves C-A, Rodrigues L, Bobermin LD et al (2018) Glycolysis-derived compounds from astrocytes that modulate synaptic communication. Front Neurosci 12:1035. https://doi.org/10.3389/fnins.2018.01035

Article  PubMed  Google Scholar 

Gottfried C, Tramontina F, Gonçalves D et al (2002) Glutamate uptake in cultured astrocytes depends on age: a study about the effect of guanosine and the sensitivity to oxidative stress induced by H2O2. Mech Ageing Dev 123:1333–1340. https://doi.org/10.1016/S0047-6374(02)00069-6

Article  CAS  PubMed  Google Scholar 

Guerrero A, De Strooper B, Arancibia-Cárcamo IL (2021) Cellular senescence at the crossroads of inflammation and Alzheimer’s disease. Trends Neurosci 44:714–727. https://doi.org/10.1016/j.tins.2021.06.007

Article  CAS  PubMed  Google Scholar 

Guillet B, Velly L, Canolle B et al (2005) Differential regulation by protein kinases of activity and cell surface expression of glutamate transporters in neuron-enriched cultures. Neurochem Int 46:337–346. https://doi.org/10.1016/j.neuint.2004.10.006

Article  CAS  PubMed  Google Scholar 

Jayakumar AR, Norenberg MD (2016) Glutamine synthetase: role in neurological disorders. Adv Neurobiol 13:327–350. https://doi.org/10.1007/978-3-319-45096-4_13

Article  PubMed  Google Scholar 

Kleinkauf-Rocha J, Bobermin LD, de Mattos Machado P et al (2013) Lipoic acid increases glutamate uptake, glutamine synthetase activity and glutathione content in C6 astrocyte cell line. Int J Dev Neurosci 31:165–170. https://doi.org/10.1016/j.ijdevneu.2012.12.006

Article  CAS  PubMed  Google Scholar 

Lau V, Ramer L, Tremblay M-È (2023) An aging, pathology burden, and glial senescence build-up hypothesis for late onset Alzheimer’s disease. Nat Commun 14:1670. https://doi.org/10.1038/s41467-023-37304-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lawrence JM, Schardien K, Wigdahl B, Nonnemacher MR (2023) Roles of neuropathology-associated reactive astrocytes: a systematic review. Acta Neuropathol Commun 11:42. https://doi.org/10.1186/s40478-023-01526-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee M, Cho T, Jantaratnotai N et al (2010) Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases. FASEB J 24:2533–2545. https://doi.org/10.1096/fj.09-149997

Article  CAS  PubMed  Google Scholar 

Leite Santos C, Vizuete AFK, Weber FB et al (2023) Age-dependent effects of resveratrol in hypothalamic astrocyte cultures. NeuroReport 34:419–425. https://doi.org/10.1097/WNR.0000000000001906

Article  CAS  PubMed  Google Scholar 

Letiembre M, Hao W, Liu Y et al (2007) Innate immune receptor expression in normal brain aging. Neuroscience 146:248–254. https://doi.org/10.1016/j.neuroscience.2007.01.004

Article  CAS  PubMed  Google Scholar 

Limbad C, Oron TR, Alimirah F et al (2020) Astrocyte senescence promotes glutamate toxicity in cortical neurons. PLoS ONE 15:e0227887. https://doi.org/10.1371/journal.pone.0227887

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu X-L, Zhao Y-C, Zhu H-Y et al (2021) Taxifolin retards the d -galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in mice. Food Funct 12:12142–12158. https://doi.org/10.1039/D1FO01349A

Article  CAS  PubMed  Google Scholar 

Liu Y, Shen X, Zhang Y et al (2023) Interactions of glial cells with neuronal synapses, from astrocytes to microglia and oligodendrocyte lineage cells. Glia 71:1383–1401. https://doi.org/10.1002/glia.24343

Article  PubMed  Google Scholar 

Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402–408. https://doi.org/10.1006/meth.2001.1262

Article  CAS  PubMed  Google Scholar 

López-Otín C, Blasco MA, Partridge L et al (2013) The hallmarks of aging. Cell 153:1194–1217. https://doi.org/10.1016/j.cell.2013.05.039

Article  CAS  PubMed  PubMed Central  Google Scholar 

López-Teros M, Alarcón-Aguilar A, López-Diazguerrero NE et al (2022) Contribution of senescent and reactive astrocytes on central nervous system inflammaging. Biogerontology 23:21–33. https://doi.org/10.1007/s10522-022-09952-3

Article  CAS  PubMed

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