Resting state functional connectivity modifications in monoaminergic circuits underpin fatigue development in patients with multiple sclerosis

Oliva Ramirez A, Keenan A, Kalau O, Worthington E, Cohen L, Singh S. Prevalence and burden of multiple sclerosis-related fatigue: a systematic literature review. BMC Neurol. 2021;21:468.

Article  PubMed  PubMed Central  Google Scholar 

Marchesi O, Vizzino C, Meani A, Conti L, Riccitelli GC, Preziosa P, et al. Fatigue in multiple sclerosis patients with different clinical phenotypes: a clinical and magnetic resonance imaging study. Eur J Neurol. 2020;27:2549–60.

Article  CAS  PubMed  Google Scholar 

Roelcke U, Kappos L, Lechner-Scott J, Brunnschweiler H, Huber S, Ammann W, et al. Reduced glucose metabolism in the frontal cortex and basal ganglia of multiple sclerosis patients with fatigue: a 18F-fluorodeoxyglucose positron emission tomography study. Neurology. 1997;48:1566–71.

Article  CAS  PubMed  Google Scholar 

Tellez N, Alonso J, Rio J, Tintore M, Nos C, Montalban X, et al. The basal ganglia: a substrate for fatigue in multiple sclerosis. Neuroradiology. 2008;50:17–23.

Article  CAS  PubMed  Google Scholar 

Tartaglia MC, Narayanan S, Francis SJ, Santos AC, De Stefano N, Lapierre Y, et al. The relationship between diffuse axonal damage and fatigue in multiple sclerosis. Arch Neurol. 2004;61:201–7.

Article  PubMed  Google Scholar 

Finke C, Schlichting J, Papazoglou S, Scheel M, Freing A, Soemmer C, et al. Altered basal ganglia functional connectivity in multiple sclerosis patients with fatigue. Mult Scler. 2015;21:925–34.

Article  CAS  PubMed  Google Scholar 

Rocca MA, Meani A, Riccitelli GC, Colombo B, Rodegher M, Falini A, et al. Abnormal adaptation over time of motor network recruitment in multiple sclerosis patients with fatigue. Mult Scler. 2016;22:1144–53.

Article  PubMed  Google Scholar 

Cruz Gomez AJ, Ventura Campos N, Belenguer A, Avila C, Forn C. Regional brain atrophy and functional connectivity changes related to fatigue in multiple sclerosis. PLoS ONE. 2013;8:e77914.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pravata E, Zecca C, Sestieri C, Caulo M, Riccitelli GC, Rocca MA, et al. Hyperconnectivity of the dorsolateral prefrontal cortex following mental effort in multiple sclerosis patients with cognitive fatigue. Mult Scler. 2016;22:1665–75.

Article  PubMed  Google Scholar 

Engstrom M, Flensner G, Landtblom AM, Ek AC, Karlsson T. Thalamo-striato-cortical determinants to fatigue in multiple sclerosis. Brain Behav. 2013;3:715–28.

Article  PubMed  PubMed Central  Google Scholar 

Arm J, Ribbons K, Lechner-Scott J, Ramadan S. Evaluation of MS related central fatigue using MR neuroimaging methods: scoping review. J Neurol Sci. 2019;400:52–71.

Article  PubMed  Google Scholar 

Bertoli M, Tecchio F. Fatigue in multiple sclerosis: does the functional or structural damage prevail? Mult Scler. 2020;26:1809–15.

Article  PubMed  Google Scholar 

Filippi M, Preziosa P, Rocca MA. Brain mapping in multiple sclerosis: lessons learned about the human brain. Neuroimage. 2019;190:32–45.

Article  PubMed  Google Scholar 

White AT, Lee JN, Light AR, Light KC. Brain activation in multiple sclerosis: a BOLD fMRI study of the effects of fatiguing hand exercise. Mult Scler. 2009;15:580–6.

Article  CAS  PubMed  Google Scholar 

Filippi M, Rocca MA, Colombo B, Falini A, Codella M, Scotti G, et al. Functional magnetic resonance imaging correlates of fatigue in multiple sclerosis. Neuroimage. 2002;15:559–67.

Article  CAS  PubMed  Google Scholar 

Hidalgo de la Cruz M, d’Ambrosio A, Valsasina P, Pagani E, Colombo B, Rodegher M, et al. Abnormal functional connectivity of thalamic sub-regions contributes to fatigue in multiple sclerosis. Mult Scler. 2018;24:1183–95.

Article  PubMed  Google Scholar 

DeLuca J, Genova HM, Hillary FG, Wylie G. Neural correlates of cognitive fatigue in multiple sclerosis using functional MRI. J Neurol Sci. 2008;270:28–39.

Article  PubMed  Google Scholar 

Genova HM, Rajagopalan V, Deluca J, Das A, Binder A, Arjunan A, et al. Examination of cognitive fatigue in multiple sclerosis using functional magnetic resonance imaging and diffusion tensor imaging. PLoS ONE. 2013;8:e78811.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arm J, Oeltzschner G, Al-Iedani O, Lea R, Lechner-Scott J, Ramadan S. Altered in vivo brain GABA and glutamate levels are associated with multiple sclerosis central fatigue. Eur J Radiol. 2021;137:109610.

Article  PubMed  PubMed Central  Google Scholar 

Carotenuto A, Valsasina P, Preziosa P, Mistri D, Filippi M, Rocca MA. Monoaminergic network abnormalities: a marker for multiple sclerosis-related fatigue and depression. J Neurol Neurosurg Psychiatry. 2023;94:94–101.

Article  PubMed  Google Scholar 

Cercignani M, Dipasquale O, Bogdan I, Carandini T, Scott J, Rashid W, et al. Cognitive fatigue in multiple sclerosis is associated with alterations in the functional connectivity of monoamine circuits. Brain Commun. 2021;3:fcab023.

Article  PubMed  PubMed Central  Google Scholar 

Fiore A, Preziosa P, Tedone N, Margoni M, Vizzino C, Mistri D, et al. Correspondence among gray matter atrophy and atlas-based neurotransmitter maps is clinically relevant in multiple sclerosis. Mol Psychiatry. 2023;28:1770–82.

Flachenecker P, Kumpfel T, Kallmann B, Gottschalk M, Grauer O, Rieckmann P, et al. Fatigue in multiple sclerosis: a comparison of different rating scales and correlation to clinical parameters. Mult Scler. 2002;8:523–6.

Article  CAS  PubMed  Google Scholar 

Whitfield-Gabrieli S, Nieto-Castanon A. Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks. Brain Connect. 2012;2:125–41.

Article  PubMed  Google Scholar 

Behzadi Y, Restom K, Liau J, Liu TT. A component based noise correction method (CompCor) for BOLD and perfusion based fMRI. Neuroimage. 2007;37:90–101.

Article  PubMed  Google Scholar 

Gómez FJG, Huertas I, Ramírez JAL, Solís DG. Elaboración de una plantilla de SPM para la normalización de imágenes de PET con 18F-DOPA. Imagen Diagnóstica. 2018;9:23–25.

Google Scholar 

Hesse S, Moeller F, Petroff D, Lobsien D, Luthardt J, Regenthal R, et al. Altered serotonin transporter availability in patients with multiple sclerosis. Eur J Nucl Med Mol Imaging. 2014;41:827–35.

Article  CAS  PubMed  Google Scholar 

Schmidt E, Schinke C, Rullmann M, Luthardt J, Becker GA, Haars S, et al. Changes of central noradrenaline transporter availability in immunotherapy-naive multiple sclerosis patients. Sci Rep. 2020;10:14651.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carandini T, Mancini M, Bogdan I, Rae CL, Barritt AW, Sethi A, et al. Disruption of brainstem monoaminergic fibre tracts in multiple sclerosis as a putative mechanism for cognitive fatigue: a fixel-based analysis. Neuroimage Clin. 2021;30:102587.

Article  PubMed  PubMed Central  Google Scholar 

Jaeger S, Paul F, Scheel M, Brandt A, Heine J, Pach D, et al. Multiple sclerosis-related fatigue: altered resting-state functional connectivity of the ventral striatum and dorsolateral prefrontal cortex. Mult Scler. 2019;25:554–64.

Article  PubMed  Google Scholar 

Rocca MA, Valsasina P, Lamanna MT, Colombo B, Martinelli V, Filippi M. Functional connectivity modifications in monoaminergic circuits occur in fatigued MS patients treated with fampridine and amantadine. J Neurol. 2023;270:4697–706.

Stefancin P, Govindarajan ST, Krupp L, Charvet L, Duong TQ. Resting-state functional connectivity networks associated with fatigue in multiple sclerosis with early age onset. Mult Scler Relat Disord. 2019;31:101–5.

Article  PubMed  Google Scholar 

Rocca MA, Valsasina P, Colombo B, Martinelli V, Filippi M. Cortico-subcortical functional connectivity modifications in fatigued multiple sclerosis patients treated with fampridine and amantadine. Eur J Neurol. 2021;28:2249–58.

Article  PubMed  Google Scholar 

Minagar A, Barnett MH, Benedict RH, Pelletier D, Pirko I, Sahraian MA, et al. The thalamus and multiple sclerosis: modern views on pathologic, imaging, and clinical aspects. Neurology. 2013;80:210–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou K, Zhu L, Hou G, Chen X, Chen B, Yang C, et al. The contribution of thalamic nuclei in salience processing. Front Behav Neurosci. 2021;15:634618.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rocca MA, Agosta F, Colombo B, Mezzapesa DM, Falini A, Comi G, et al. fMRI changes in relapsing-remitting multiple sclerosis patients complaining of fatigue after IFNbeta-1a injection. Hum Brain Mapp. 2007;28:373–82.

Article  PubMed  Google Scholar 

Schoonheim MM, Meijer KA, Geurts JJ. Network collapse and cognitive impairment in multiple sclerosis. Front Neurol. 2015;6:82.

Article  PubMed  PubMed Central  Google Scholar 

Chahin S, Miller D, Sakai RE, Wilson JA, Frohman T, Markowitz C, et al. Relation of quantitative visual and neurologic outcomes to fatigue in multiple sclerosis. Mult Scler Relat Disord. 2015;4:304–10.

Article  PubMed  Google Scholar 

留言 (0)

沒有登入
gif