American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-5TM, 5th ed. Arlington, VA, US: American Psychiatric Publishing, Inc.; 2013. xliv, 947 p. (Diagnostic and statistical manual of mental disorders: DSM-5TM, 5th ed).

Benjet C, Bromet E, Karam EG, Kessler RC, McLaughlin KA, Ruscio AM, et al. The epidemiology of traumatic event exposure worldwide: results from the World Mental Health Survey Consortium. Psychol Med. 2016;46:327–43.

Article  CAS  PubMed  Google Scholar 

Paganin W, Signorini S. Biomarkers of post-traumatic stress disorder from emotional trauma: a systematic review. Eur J Trauma Dissociation. 2023;7:100328.

Article  Google Scholar 

Bonanno GA. Loss, trauma, and human resilience: Have we underestimated the human capacity to thrive after extremely aversive events? Psychol Trauma Theory Res Pr Policy. 2008;S:101–13.

Article  Google Scholar 

Galatzer-Levy IR, Huang SH, Bonanno GA. Trajectories of resilience and dysfunction following potential trauma: a review and statistical evaluation. Clin Psychol Rev. 2018;63:41–55.

Article  PubMed  Google Scholar 

McLaughlin KA, Koenen KC, Hill ED, Petukhova M, Sampson NA, Zaslavsky AM, et al. Trauma exposure and posttraumatic stress disorder in a national sample of adolescents. J Am Acad Child Adolesc Psychiatry. 2013;52:815–830.e14.

Article  PubMed  PubMed Central  Google Scholar 

Blom M, Oberink R. The validity of the DSM-IV PTSD criteria in children and adolescents: a review. Clin Child Psychol Psychiatry. 2012;17:571–601.

Article  PubMed  Google Scholar 

Ramsdell KD, Smith AJ, Hildenbrand AK, Marsac ML. Posttraumatic stress in school-age children and adolescents: medical providers’ role from diagnosis to optimal management. Pediatr Health Med Ther. 2015;6:167–80.

Google Scholar 

Cover KK, Maeng LY, Lebrón-Milad K, Milad MR. Mechanisms of estradiol in fear circuitry: implications for sex differences in psychopathology. Transl Psychiatry. 2014;4:e422–e422.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miller-Graff LE, Howell KH. Posttraumatic stress symptom trajectories among children exposed to violence. J Trauma Stress. 2015;28:17–24.

Article  PubMed  Google Scholar 

Tolin DF, Foa EB. Sex differences in trauma and posttraumatic stress disorder: a quantitative review of 25 years of research. Psychol Bull. 2006;132:959–92.

Article  PubMed  Google Scholar 

Helpman L, Zhu X, Suarez-Jimenez B, Lazarov A, Monk C, Neria Y. Sex differences in trauma-related psychopathology: a critical review of neuroimaging literature (2014–2017). Curr Psychiatry Rep. 2017;19:104.

Article  PubMed  PubMed Central  Google Scholar 

Eder-Moreau E, Zhu X, Fisch CT, Bergman M, Neria Y, Helpman L. Neurobiological alterations in females with PTSD: a systematic review. Front Psychiatry. 2022 ;13:862476.

Article  PubMed  PubMed Central  Google Scholar 

Brunello N, Davidson JR, Deahl M, Kessler RC, Mendlewicz J, Racagni G, et al. Posttraumatic stress disorder: diagnosis and epidemiology, comorbidity and social consequences, biology and treatment. Neuropsychobiology. 2001;43:150–62.

Article  CAS  PubMed  Google Scholar 

Pietrzak RH, Goldstein RB, Southwick SM, Grant BF. Physical Health Conditions Associated with Posttraumatic Stress Disorder in U.S. Older Adults: Results from Wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions. J Am Geriatr Soc. 2012;60:296–303.

Article  PubMed  PubMed Central  Google Scholar 

Fani N, Jain J, Hudak LA, Rothbaum BO, Ressler KJ, Michopoulos V. Post-trauma anhedonia is associated with increased substance use in a recently-traumatized population. Psychiatry Res. 2020;285:112777.

Article  PubMed  PubMed Central  Google Scholar 

Brady KT, Killeen TK, Brewerton T, Lucerini S. Comorbidity of psychiatric disorders and posttraumatic stress disorder. J Clin Psychiatry. 2000;61:22–32.

PubMed  Google Scholar 

Foa EB, Hembree EA, Cahill SP, Rauch SAM, Riggs DS, Feeny NC, et al. Randomized trial of prolonged exposure for posttraumatic stress disorder with and without cognitive restructuring: Outcome at academic and community clinics. J Consult Clin Psychol. 2005;73:953–64.

Article  PubMed  Google Scholar 

Schottenbauer MA, Glass CR, Arnkoff DB, Tendick V, Gray SH. Nonresponse and dropout rates in outcome studies on PTSD: review and methodological considerations. Psychiatry. 2008;71:134–68.

Article  PubMed  Google Scholar 

Bradley R, Greene J, Russ E, Dutra L, Westen D. A multidimensional meta-analysis of psychotherapy for PTSD. Am J Psychiatry. 2005 ;162:214–27.

Article  PubMed  Google Scholar 

Schnurr PP, Chard KM, Ruzek JI, Chow BK, Resick PA, Foa EB, et al. Comparison of prolonged exposure vs cognitive processing therapy for treatment of posttraumatic stress disorder among US veterans: a randomized clinical trial. JAMA Netw Open. 2022;5:e2136921.

Article  PubMed  PubMed Central  Google Scholar 

Lewis C, Roberts NP, Gibson S, Bisson JI. Dropout from psychological therapies for post-traumatic stress disorder (PTSD) in adults: systematic review and meta-analysis. Eur J Psychotraumatol. 2020;11:1709709.

Article  PubMed  PubMed Central  Google Scholar 

Davis RG, Ressler KJ, Schwartz AC, Stephens KJ, Bradley RG. Treatment barriers for low-income, urban african americans with undiagnosed posttraumatic stress disorder. J Trauma Stress. 2008;21:218–22.

Article  PubMed  PubMed Central  Google Scholar 

Cipriani A, Williams T, Nikolakopoulou A, Salanti G, Chaimani A, Ipser J, et al. Comparative efficacy and acceptability of pharmacological treatments for post-traumatic stress disorder in adults: a network meta-analysis. Psychol Med. 2018;48:1975–84.

Article  PubMed  Google Scholar 

Henner RL, Keshavan MS, Hill KP. Review of potential psychedelic treatments for PTSD. J Neurol Sci. 2022;439:120302.

Article  PubMed  Google Scholar 

Krediet E, Bostoen T, Breeksema J, van Schagen A, Passie T, Vermetten E. Reviewing the potential of psychedelics for the treatment of PTSD. Int J Neuropsychopharmacol. 2020;23:385–400.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barawi KS, Lewis C, Simon N, Bisson JI. A systematic review of factors associated with outcome of psychological treatments for post-traumatic stress disorder. Eur J Psychotraumatol. 2020;11:1774240.

Merz J, Schwarzer G, Gerger H. Comparative efficacy and acceptability of pharmacological, psychotherapeutic, and combination treatments in adults with posttraumatic stress disorder: a network meta-analysis. JAMA Psychiatry. 2019;76:904–13.

Article  PubMed  PubMed Central  Google Scholar 

Bremner JD, Randall P, Scott TM, Bronen RA, Seibyl JP, Southwick SM, et al. MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder. Am J Psychiatry. 1995;152:973–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shalev A, Liberzon I, Marmar C. Post-traumatic stress disorder. Longo DL, editor. N Engl J Med. 2017;376:2459–69.

Liberzon I, Abelson JL. Context processing and the neurobiology of post-traumatic stress disorder. Neuron. 2016;92:14–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Patel R, Spreng RN, Shin LM, Girard TA. Neurocircuitry models of posttraumatic stress disorder and beyond: a meta-analysis of functional neuroimaging studies. Neurosci Biobehav Rev. 2012;36:2130–42.

Article  PubMed  Google Scholar 

Pitman RK, Rasmusson AM, Koenen KC, Shin LM, Orr SP, Gilbertson MW, et al. Biological studies of posttraumatic stress disorder. Nat Rev Neurosci. 2012;13:769–87.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rauch SL, Shin LM, Phelps EA. Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research-past, present, and future. Biol Psychiatry. 2006;60:376–82.

Article  PubMed  Google Scholar 

Ross MC, Cisler JM. Altered large-scale functional brain organization in posttraumatic stress disorder: A comprehensive review of univariate and network-level neurocircuitry models of PTSD. NeuroImage Clin. 2020;27:102319.

Article  PubMed  PubMed Central  Google Scholar 

Shin LM, Rauch SL, Pitman RK. Amygdala, medial prefrontal cortex, and hippocampal function in PTSD. Ann N. Y Acad Sci. 2006;1071:67–79.

Article  PubMed  Google Scholar 

O’Doherty DCM, Chitty KM, Saddiqui S, Bennett MR, Lagopoulos J. A systematic review and meta-analysis of magnetic resonance imaging measurement of structural volumes in posttraumatic stress disorder. Psychiatry Res Neuroimaging. 2015;232:1–33.

Article  Google Scholar 

Hinojosa CA. Does hippocampal volume in patients with posttraumatic stress disorder vary by trauma type? Harv Rev Psychiatry. 2022;30:118.

Article  PubMed  Google Scholar 

Ben-Zion Z, Korem N, Fine N, Katz S, Siddhanta M, Funaro MC, et al. Structural neuroimaging of hippocampus and amygdala subregions in post-traumatic stress disorder (PTSD): a scoping review. Biol Psychiatry Glob Open Sci [Internet]. 2023 [cited 2023 Aug 29]; Available from: https://www.sciencedirect.com/science/article/pii/S2667174323000812.

van Rooij SJH, Sippel LM, McDonald WM, Holtzheimer PE. Defining focal brain stimulation targets for PTSD using neuroimaging. Depress Anxiety. 2021. https://doi.org/10.1002/da.23159.

Backhausen LL, Herting MM, Tamnes CK, Vetter NC. Best practices in structural neuroimaging of neurodevelopmental disorders. Neuropsychol Rev. 2022;32:400–18.

Article  PubMed  Google Scholar 

Figley CR, Uddin MN, Wong K, Kornelsen J, Puig J, Figley TD. Potential pitfalls of using fractional anisotropy, axial diffusivity, and radial diffusivity as biomarkers of cerebral white matter microstructure. Front Neurosci [Internet]. 2022 [cited 2023 Sep 14];15. Available from: https://www.frontiersin.org/articles/10.3389/fnins.2021.799576.

Bassett DS, Sporns O. Network neuroscience. Nat Neurosci. 2017;20:353–64.

Article  CAS