Raekallio J (1972) Determination of the age of wounds by histochemical and biochemical methods. Forensic Sci Int 1(1):3–16

Article  CAS  Google Scholar 

Kondo T (2007) Timing of skin wounds. Legal Med (Tokyo) 9(2):109–114

Article  Google Scholar 

Kondo T, Ishida Y (2010) Molecular pathology of wound healing. Forensic Sci Int 203(1–3):93–98

Article  CAS  PubMed  Google Scholar 

Betz P (1994) Histological and enzyme histochemical parameters for the age estimation of human skin wounds. Int J Legal Med 107(2):60–68

Article  CAS  PubMed  Google Scholar 

Gauchotte G, Wissler MP, Casse JM, Pujo J, Minetti C, Gisquet H, Vigouroux C, Plénat F, Vignaud JM, Martrille L (2013) FVIIIra, CD15, and tryptase performance in the diagnosis of skin stab wound vitality in forensic pathology. Int J Legal Med 127(5):957–965

Article  PubMed  Google Scholar 

Betz P, Eisenmenger W (1996) Morphometrical analysis of hemosiderin deposits in relation to wound age. Int J Legal Med 108(5):262–264

Article  CAS  PubMed  Google Scholar 

Laiho K (1998) Myeloperoxidase activity in skin lesions. I. Influence of the loss of blood, depth of excoriations and thickness of the skin. Int J Legal Med 111(1):6–9

Article  CAS  PubMed  Google Scholar 

Singer AJ, Clark RA (1999) Cutaneous wound healing. N Engl J Med 341(10):738–746

Article  CAS  PubMed  Google Scholar 

Reinke JM, Sorg H (2012) Wound repair and regeneration. Eur Surg Res 49(1):35–43

Article  CAS  PubMed  Google Scholar 

Patel S, Maheshwari A, Chandra A (2016) Biomarkers for wound healing and their evaluation. J Wound Care 25(1):46–55

Article  CAS  PubMed  Google Scholar 

Khalaf AA, Hassanen EI, Zaki AR, Tohamy AF, Ibrahim MA (2019) Histopathological, immunohistochemical, and molecular studies for determination of wound age and vitality in rats. Int Wound J 16(6):1416–1425

Article  PubMed  PubMed Central  Google Scholar 

Wang YN, Yamamoto Y, Kuninaka Y, Kondo T, Furukawa F (2015) Forensic potential of MMPs and CC chemokines for Wound Age determination. J Forensic Sci 60(6):1511–1515

Article  CAS  PubMed  Google Scholar 

Abd-Elhakim YM, Omran BHF, Ezzeldein SA, Ahmed AI, El-Sharkawy NI, Mohamed AA (2022) Time-dependent expression of high-mobility Group box-1 and toll-like receptors proteins as potential determinants of skin wound age in rats: forensic implication. Int J Legal Med 136(6):1781–1789

Article  PubMed  PubMed Central  Google Scholar 

Birincioğlu İ, Akbaba M, Alver A, Kul S, Özer E, Turan N, Şentürk A, İnce İ (2016) Determination of skin wound age by using cytokines as potential markers. J Forensic Leg Med 44:14–19

Article  PubMed  Google Scholar 

Gao Y, Cai LW, Li DY, Li LL, Wu YL, Ren WJ, Song YR, Zhu LW, Wu YZ, Xu H, Luo CL, Wang T, Lei ZG, Tao LY (2023) Extended characterization of IL-33/ST2 as a predictor for wound age determination in skin wound tissue samples of humans and mice. Int J Legal Med 137(4):1287–1299

Article  PubMed  Google Scholar 

Fronczek J, Lulf R, Korkmaz HI, Witte BI, van de Goot FR, Begieneman MP, Schalkwijk CG, Krijnen PA, Rozendaal L, Niessen HW, Reijnders UJ (2015) Analysis of inflammatory cells and mediators in skin wound biopsies to determine wound age in living subjects in forensic medicine. Forensic Sci Int 247:7–13

Article  CAS  PubMed  Google Scholar 

Grellner W, Vieler S, Madea B (2005) Transforming growth factors (TGF-α and TGF-β) in the determination of vitality and wound age: immunohistochemical study on human skin wounds. Forensic Sci Int 153(2–3):174–180

Article  CAS  PubMed  Google Scholar 

Ishida Y, Kimura A, Takayasu T, Eisenmenger W, Kondo T (2009) Detection of fibrocytes in human skin wounds and its application for wound age determination. Int J Legal Med 123(4):299–304

Article  PubMed  Google Scholar 

Kondo T, Ohshima T, Mori R, Guan DW, Ohshima K, Eisenmenger W (2002) Immunohistochemical detection of chemokines in human skin wounds and its application to wound age determination. Int J Legal Med 116(2):87–91

Article  CAS  PubMed  Google Scholar 

Kondo T, Ohshima T (1996) The dynamics of inflammatory cytokines in the healing process of mouse skin wound: a preliminary study for possible wound age determination. Int J Legal Med 108(5):231–236

Article  CAS  PubMed  Google Scholar 

Kondo T, Ohshima T, Eisenmenger W (1999) Immunohistochemical and morphometrical study on the temporal expression of interleukin-1α (IL-1α) in human skin wounds for forensic wound age determination. Int J Legal Med 112(4):249–252

Article  CAS  PubMed  Google Scholar 

Alvarez RH, Kantarjian HM, Cortes JE (2006) Biology of platelet-derived growth factor and its involvement in disease. Mayo Clin Proc 81(9):1241–1257

Article  CAS  PubMed  Google Scholar 

Deuel TF, Senior RM, Huang JS, Griffin GL (1982) Chemotaxis of monocytes and neutrophils to platelet-derived growth factor J. Clin Invest 69(4):1046–1049

Article  CAS  Google Scholar 

Grotendorst GR, Seppä HE, Kleinman HK, Martin GR (1981) Attachment of smooth muscle cells to collagen and their migration toward platelet-derived growth factor, Proc. Natl. Acad. Sei. USA 78(6):3669–3672

Senior RM, Griffin GL, Huang JS, Walz DA, Deuel TF (1983) Chemotactic activity of platelet alpha granule proteins for fibroblasts J. Cell Biol 96(2):382–385

Article  CAS  Google Scholar 

Seppä H, Grotendorst G, Seppä S, Schiffmann E, Martin GR (1982) Platelet-derived growth factor is chemotactic for fibroblasts J. Cell Biol 92(2):584–588

Article  Google Scholar 

Siegbahn A, Hammacher A, Westermark B, Heldin CH (1990) Differential effects of the various isoforms of platelet-derived growth factor on chemotaxis of fibroblasts, monocytes, and granulocytes. J Clin Invest 85(3):916–920

Article  CAS  PubMed  PubMed Central  Google Scholar 

Clark RA, Folkvord JM, Hart CE, Murray MJ, McPherson JM (1989) Platelet isoforms of platelet-derived growth factor stimulate fibroblasts to contract collagen matrices. J Clin Invest 84(3):1036–1040

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gullberg D, Tingström A, Thuresson AC, Olsson L, Terracio L, Borg TK, Rubin K (1990) Beta 1 integrin-mediated collagen gel contraction is stimulated by PDGF. Exp Cell Res 186(2):264–272

Article  CAS  PubMed  Google Scholar 

Beer HD, Fässler R, Werner S (2000) Glucocorticoid-regulated gene expression during cutaneous wound repair. Vitam Horm 59:217–239

Article  CAS  PubMed  Google Scholar 

Beer HD, Longaker MT, Werner S (1997) Reduced expression of PDGF and PDGF receptors during impaired wound healing. J Invest Dermatol 109(2):132–138

Article  CAS  PubMed  Google Scholar 

Ishida Y, Kimura A, Takayasu T, Eisenmenger W, Kondo T (2008) Expression of oxygen-regulated protein 150 (ORP150) in skin wound healing and its application for wound age determination. Int J Legal Med 122(5):409–414

Article  CAS  PubMed  Google Scholar 

Hayashi T, Ishida Y, Kimura A, Takayasu T, Eisenmenger W, Kondo T (2004) Forensic application of VEGF expression to skin wound age determination. Int J Legal Med 118(6):320–325

Article  PubMed  Google Scholar 

Ishida Y, Kimura A, Nosaka M, Kuninaka Y, Takayasu T, Eisenmenger W, Kondo T (2012) Immunohistochemical analysis on cyclooxygenase-2 for wound age determination. Int J Legal Med 126(3):435–440

Article  PubMed  Google Scholar 

Ishida Y, Kimura A, Nosaka M, Kuninaka Y, Shimada E, Yamamoto H, Nishiyama K, Inaka S, Takayasu T, Eisenmenger W, Kondo T (2015) Detection of endothelial progenitor cells in human skin wounds and its application for wound age determination. Int J Legal Med 129(5):1049–1054

Article  PubMed  Google Scholar 

Raines EW, Ross R (1992) Compartmentalization of PDGF on extracellular binding sites dependent on exon-6-encoded sequences. J Cell Biol 116(2):533–543

Article  CAS  PubMed  Google Scholar 

Grotendorst GR, Martin GR, Pencev D, Sodek J, Harvey AK (1985) Stimulation of granulation tissue formation by platelet-derived growth factor in normal and diabetic rats. J Clin Lnvest 76(6):2323–2339

Article  CAS  Google Scholar 

Sprugel KH, McPherson JM, Clowes AW, Ross R (1987) Effects of growth factors in vivo. I. Cell ingrowth into porous subcutaneous chambers. Am J Pathol 129(3):601–613

CAS  PubMed  PubMed Central  Google Scholar 

Heldin CH, Westermark B (1999) Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev 79(4):1283–1316

Article