Yuen M-F, Chen D-S, Dusheiko GM, Janssen HLA, Lau DTY, Locarnini SA, Peters MG, Lai C-L. Hepatitis B virus infection. Nat Reviews Disease Primers 2018, 4.

Razavi H. Global epidemiology of viral Hepatitis. Gastroenterol Clin N Am. 2020;49:179–89.

Article  Google Scholar 

Liu Z, Lin C, Mao X, Guo C, Suo C, Zhu D, Jiang W, Li Y, Fan J, Song C, et al. Changing prevalence of chronic hepatitis B virus infection in China between 1973 and 2021: a systematic literature review and meta-analysis of 3740 studies and 231 million people. Gut. 2023;72:2354–63.

Article  PubMed  Google Scholar 

Nguyen MH, Wong G, Gane E, Kao J-H, Dusheiko G. Hepatitis B Virus: advances in Prevention, diagnosis, and Therapy. Clin Microbiol Rev 2020, 33.

Rehermann B, Thimme R. Insights from antiviral therapy into Immune responses to Hepatitis B and C Virus infection. Gastroenterology. 2019;156:369–83.

Article  CAS  PubMed  Google Scholar 

Niu C, Li L, Daffis S, Lucifora J, Bonnin M, Maadadi S, Salas E, Chu R, Ramos H, Livingston CM, et al. Toll-like receptor 7 agonist GS-9620 induces prolonged inhibition of HBV via a type I interferon-dependent mechanism. J Hepatol. 2018;68:922–31.

Article  CAS  PubMed  Google Scholar 

Hopfner K-P, Hornung V. Molecular mechanisms and cellular functions of cGAS–STING signalling. Nat Rev Mol Cell Biol. 2020;21:501–21.

Article  CAS  PubMed  Google Scholar 

Kato K, Omura H, Ishitani R, Nureki O. Cyclic GMP–AMP as an endogenous second Messenger in Innate Immune Signaling by cytosolic DNA. Annu Rev Biochem. 2017;86:541–66.

Article  CAS  PubMed  Google Scholar 

Shen S, Rui Y, Wang Y, Su J, Yu XF. SARS-CoV‐2, HIV, and HPV: convergent evolution of selective regulation of cGAS–STING signaling. J Med Virol 2022, 95.

Lahaye X, Gentili M, Silvin A, Conrad C, Picard L, Jouve M, Zueva E, Maurin M, Nadalin F, Knott GJ, et al. NONO detects the Nuclear HIV Capsid to promote cGAS-Mediated Innate Immune activation. Cell. 2018;175:488–e501422.

Article  CAS  PubMed  Google Scholar 

Motwani M, Pesiridis S, Fitzgerald KA. DNA sensing by the cGAS–STING pathway in health and disease. Nat Rev Genet. 2019;20:657–74.

Article  CAS  PubMed  Google Scholar 

Zhang J, Zhao J, Xu S, Li J, He S, Zeng Y, Xie L, Xie N, Liu T, Lee K, et al. Species-specific deamidation of cGAS by herpes Simplex Virus UL37 protein facilitates viral replication. Cell Host Microbe. 2018;24:234–e248235.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156:317–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ursini F, Maiorino M, Forman HJ. Redox homeostasis: the Golden Mean of healthy living. Redox Biol. 2016;8:205–15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Agmon E, Stockwell BR. Lipid homeostasis and regulated cell death. Curr Opin Chem Biol. 2017;39:83–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jia M, Qin D, Zhao C, Chai L, Yu Z, Wang W, Tong L, Lv L, Wang Y, Rehwinkel J, et al. Redox homeostasis maintained by GPX4 facilitates STING activation. Nat Immunol. 2020;21:727–35.

Article  CAS  PubMed  Google Scholar 

Terrault NA, Lok ASF, McMahon BJ, Chang KM, Hwang JP, Jonas MM, Brown RS, Bzowej NH, Wong JB. Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance. Hepatology. 2018;67:1560–99.

Article  PubMed  Google Scholar 

Li L-C, Dahiya R. MethPrimer: designing primers for methylation PCRs. Bioinformatics. 2002;18:1427–31.

Article  CAS  PubMed  Google Scholar 

Gao S, Sun FK, Fan YC, Shi CH, Zhang ZH, Wang LY, Wang K. AberrantGSTP1promoter methylation predicts short-term prognosis in acute-on-chronic hepatitis B liver failure. Aliment Pharmacol Ther. 2015;42:319–29.

Article  PubMed  Google Scholar 

Wong GLH, Gane E, Lok ASF. How to achieve functional cure of HBV: stopping NUCs, adding interferon or new drug development? J Hepatol. 2022;76:1249–62.

Article  CAS  PubMed  Google Scholar 

Kim G-A, Lim Y-S, An J, Lee D, Shim JH, Kim KM, Lee HC, Chung Y-H, Lee YS, Suh DJ. HBsAg seroclearance after nucleoside analogue therapy in patients with chronic hepatitis B: clinical outcomes and durability. Gut. 2014;63:1325–32.

Article  CAS  PubMed  Google Scholar 

Anderson RT, Lim SG, Mishra P, Josephson F, Donaldson E, Given B, Miller V. Challenges, considerations, and principles to guide trials of Combination therapies for Chronic Hepatitis B Virus. Gastroenterology. 2019;156:529–e533524.

Article  PubMed  Google Scholar 

Lau GKK, Piratvisuth T, Luo KX, Marcellin P, Thongsawat S, Cooksley G, Gane E, Fried MW, Chow WC, Paik SW, et al. Peginterferon Alfa-2a, Lamivudine, and the combination for HBeAg-Positive chronic Hepatitis B. N Engl J Med. 2005;352:2682–95.

Article  CAS  PubMed  Google Scholar 

Liaw YF, Jia JD, Chan HLY, Han KH, Tanwandee T, Chuang WL, Tan DM, Chen XY, Gane E, Piratvisuth T, et al. Shorter durations and lower doses of peginterferon alfa-2a are associated with inferior hepatitis B e antigen seroconversion rates in hepatitis B virus genotypes B or C. Hepatology. 2011;54:1591–9.

Article  CAS  PubMed  Google Scholar 

Naggie S, Lok AS. New therapeutics for Hepatitis B: the Road to cure. Annu Rev Med. 2021;72:93–105.

Article  CAS  PubMed  Google Scholar 

Cornberg M, Lok AS-F, Terrault NA, Zoulim F, Berg T, Brunetto MR, Buchholz S, Buti M, Chan HLY, Chang K-M et al. Guidance for design and endpoints of clinical trials in chronic hepatitis B - Report from the 2019 EASL-AASLD HBV Treatment Endpoints Conference‡. Journal of Hepatology 2020, 72:539–557.

Lim SG, Baumert TF, Boni C, Gane E, Levrero M, Lok AS, Maini MK, Terrault NA, Zoulim F. The scientific basis of combination therapy for chronic hepatitis B functional cure. Nat Reviews Gastroenterol Hepatol. 2023;20:238–53.

Article  CAS  Google Scholar 

Block TM, Chang K-M, Guo J-T. Prospects for the global elimination of Hepatitis B. Annual Rev Virol. 2021;8:437–58.

Article  CAS  Google Scholar 

Boni C, Vecchi A, Rossi M, Laccabue D, Giuberti T, Alfieri A, Lampertico P, Grossi G, Facchetti F, Brunetto MR, et al. TLR7 agonist increases responses of Hepatitis B virus–specific T cells and natural killer cells in patients with chronic Hepatitis B treated with Nucleos(T)Ide Analogues. Gastroenterology. 2018;154:1764–e17771767.

Article  CAS  PubMed  Google Scholar 

Suslov A, Wieland S, Menne S. Modulators of innate immunity as novel therapeutics for treatment of chronic hepatitis B. Curr Opin Virol. 2018;30:9–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo F, Han Y, Zhao X, Wang J, Liu F, Xu C, Wei L, Jiang J-D, Block TM, Guo J-T, Chang J. STING agonists induce an innate antiviral Immune response against Hepatitis B Virus. Antimicrob Agents Chemother. 2015;59:1273–81.

Article  PubMed  PubMed Central  Google Scholar 

Li Y, He M, Wang Z, Duan Z, Guo Z, Wang Z, Gong R, Chu T, Cai J, Gao B. STING signaling activation inhibits HBV replication and attenuates the severity of liver injury and HBV-induced fibrosis. Cell Mol Immunol. 2021;19:92–107.

Article  PubMed  PubMed Central  Google Scholar 

Wang C, Guan Y, Lv M, Zhang R, Guo Z, Wei X, Du X, Yang J, Li T, Wan Y, et al. Manganese increases the sensitivity of the cGAS-STING pathway for double-stranded DNA and is required for the Host Defense against DNA viruses. Immunity. 2018;48:675–e687677.

Article  CAS  PubMed  Google Scholar 

Du M, Chen ZJ. DNA-induced liquid phase condensation of cGAS activates innate immune signaling. Science. 2018;361:704–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li C, Deng X, Xie X, Liu Y, Friedmann Angeli JP, Lai L. Activation of glutathione peroxidase 4 as a novel anti-inflammatory strategy. Front Pharmacol 2018, 9.

Weaver K, Skouta R. The selenoprotein glutathione peroxidase 4: from Molecular mechanisms to Novel Therapeutic opportunities. Biomedicines 2022, 10.

Xie Y, Kang R, Klionsky DJ, Tang D. GPX4 in cell death, autophagy, and disease. Autophagy. 2023;19:2621–38.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kang R, Zeng L, Zhu S, Xie Y, Liu J, Wen Q, Cao L, Xie M, Ran Q, Kroemer G, et al. Lipid peroxidation drives gasdermin D-Mediated pyroptosis in Lethal Polymicrobial Sepsis. Cell Host Microbe. 2018;24:97–e108104.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sengupta A, Lichti UF, Carlson BA, Cataisson C, Ryscavage AO, Mikulec C, Conrad M, Fischer SM, Hatfield DL, Yuspa SH. Targeted Disruption of Glutathione Peroxidase 4 in mouse skin epithelial cells impairs postnatal hair follicle morphogenesis that is partially rescued through inhibition of COX-2. J Invest Dermatology. 2013;133:1731–41.

Article  CAS  Google Scholar 

Banning A. Inhibition of basal and interleukin-1-induced VCAM-1 expression by phospholipid hydroperoxide glutathione peroxidase and 15-lipoxygenase in rabbit aortic smooth muscle cells. Free Radic Biol Med. 2004;36:135–44.

Article  CAS  PubMed