Should Fludrocortisone be Added to Hydrocortisone in Septic Shock? Probably Yes, Based on Available Evidence*

1 The Pulmonary Center, Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA.

2 Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.

3 Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.

4 Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada.

5 Department of Anesthesia, St. Michael’s Hospital, Toronto, ON, Canada.

*See also p. e193.

Dr. Bosch is supported by the National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute, the NIH/National Center for Advancing Translational Sciences, and the Department of Defense. Dr. Teja is supported by the Canadian Institutes of Health Research and by a Merit Award from the Department of Anesthesiology and Pain Medicine, University of Toronto. Dr. Pereira has disclosed that he does not have any potential conflicts of interest.

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