Siegel RL, Miller KD, Fuchs HE, Jemal A (2022) Cancer statistics. CA Cancer J Clin 72:7–33

Article  PubMed  Google Scholar 

Giaquinto AN et al (2022) Breast cancer statistics. CA Cancer J Clin 72:524–541

Article  PubMed  Google Scholar 

Kondoh H, Kameda M, Yanagida M (2021) Whole blood metabolomics in aging research. Int J Mol Sci 22:1–13

Google Scholar 

Panyard DJ, Yu B, Snyder MP (2022) The metabolomics of human aging: advances, challenges, and opportunities. Sci Adv 8:6155

Article  Google Scholar 

Yu Z et al (2012) Human serum metabolic profiles are age dependent. Aging Cell 11:960–967

Article  CAS  PubMed  Google Scholar 

Johnson LC et al (2019) The plasma metabolome as a predictor of biological aging in humans. GeroScience 41:895–906

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bergers G, Fendt SM (2021) The metabolism of cancer cells during metastasis. Nat Rev Cancer 21:162–180

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ling HH et al (2019) Clinical significance of serum glutamine level in patients with colorectal cancer. Nutrients 11:898

Article  CAS  PubMed  PubMed Central  Google Scholar 

Recouvreux, M. V. et al. Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer. J. Exp. Med. 217, (2020).

Dunn WB et al (2015) Molecular phenotyping of a UK population: defining the human serum metabolome. Metabolomics 11:9–26

Article  CAS  PubMed  Google Scholar 

He D et al (2022) Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis. Mol Cell 82:3045-3060.e11

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gomes AP et al (2020) Age-induced methylmalonic acid accumulation promotes tumor progression. Nature 585:283

Article  CAS  PubMed  PubMed Central  Google Scholar 

Head, P. S. E. et al. Aberrant methylmalonylation underlies methylmalonic acidemia and is attenuated by an engineered sirtuin. Sci. Transl. Med. 14, (2022).

Li Z et al (2022) Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression. Nat Commun 13:1–14

Google Scholar 

Wolff AC et al (2018) Human epidermal growth factor receptor 2 testing in breast cancer: American society of clinical oncology/college of American pathologists clinical practice guideline focused update. J Clin Oncol 36:2105–2122

Article  CAS  PubMed  Google Scholar 

Mineva EM, Zhang M, Rabinowitz DJ, Phinney KW, Pfeiffer CM (2015) An LC-MS/MS method for serum methylmalonic acid suitable for monitoring vitamin B12 status in population surveys. Anal Bioanal Chem 407:2955–2964

Article  CAS  PubMed  Google Scholar 

Hannisdal R et al (2010) Analytical recovery of folate and its degradation products in human serum stored at −25°C for up to 29 years. J Nutr 140:522–526

Article  CAS  PubMed  Google Scholar 

Altea-Manzano P et al (2023) A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling. Nat. Cancer 43(4):344–364

Article  Google Scholar 

Rossi M et al (2022) PHGDH heterogeneity potentiates cancer cell dissemination and metastasis. Nature 605:747

Article  CAS  PubMed  PubMed Central  Google Scholar 

Inker LA et al (2021) New creatinine- and cystatin c-based equations to estimate GFR without race. N Engl J Med 385:1737–1749

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gomes AP et al (2022) Altered propionate metabolism contributes to tumour progression and aggressiveness. Nat Metab 4:435–443

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gomes AP et al (2020) Age-induced accumulation of methylmalonic acid promotes tumour progression. Nature 585:283–287

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gomes AP et al (2022) Altered propionate metabolism contributes to tumour progression and aggressiveness. Nat Metab 2022:1–9. https://doi.org/10.1038/S42255-022-00553-5

Article  Google Scholar 

Li Z et al (2022) Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression. Nat Commun 131(13):1–14

Google Scholar 

Kim JA et al (2020) Serum vitamin levels and their relationships with other biomarkers in Korean breast cancer patients. Nutrients 12:1–16

CAS  Google Scholar 

Abe O et al (2011) Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials. Lancet (London, England) 378:771–784

Article  Google Scholar 

Schmid P et al (2022) Event-free survival with pembrolizumab in early triple-negative breast cancer. N Engl J Med 386:556–567

Article  CAS  PubMed  Google Scholar 

Bradley R et al (2021) Trastuzumab for early-stage, HER2-positive breast cancer: a meta-analysis of 13 864 women in seven randomised trials. Lancet Oncol 22:1139–1150

Article  CAS  Google Scholar 

Piccart M et al (2021) Adjuvant pertuzumab and trastuzumab in early HER2-positive breast cancer in the APHINITY trial: 6 years’ follow-up. J Clin Oncol 39:1448–1457

Article  CAS  PubMed  Google Scholar 

Long GV et al (2022) Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma (KEYNOTE-716): distant metastasis-free survival results of a multicentre, double-blind, randomised, phase 3 trial. Lancet Oncol 23:1378–1388

Article  CAS  PubMed  Google Scholar 

Tawbi HA et al (2022) Relatlimab and nivolumab versus nivolumab in untreated advanced melanoma. N Engl J Med 386:24–34

Article  CAS  PubMed  PubMed Central  Google Scholar 

Long GV et al (2017) Adjuvant dabrafenib plus trametinib in stage III BRAF-mutated melanoma. N Engl J Med 377:1813–1823

Article  CAS  PubMed  Google Scholar 

Tang LL et al (2022) Effect of radiotherapy alone vs radiotherapy with concurrent chemoradiotherapy on survival without disease relapse in patients with low-risk nasopharyngeal carcinoma: a randomized clinical trial. JAMA 328:728–736

Article  PubMed  PubMed Central  Google Scholar 

Ganji V, Kafai MR (2018) Population reference values for serum methylmalonic acid concentrations and its relationship with age, sex, race-ethnicity, supplement use, kidney function and serum vitamin B12 in the post-folic acid fortification period. Nutrients 10:74

Article  PubMed  PubMed Central  Google Scholar