Assi V, Warwick J, Cuzick J, Duffy SW (2012) Clinical and epidemiological issues in mammographic density. Nat Rev Clin Oncol 9(1):33–40
Butler LM, Gold EB, Greendale GA, Crandall CJ, Modugno F, Oestreicher N, Quesenberry CP, Habel LA (2008) Menstrual and reproductive factors in relation to mammographic density: the Study of Women’s Health Across the Nation (SWAN). Breast Cancer Res Treat 112(1):165–174
Tehranifar P, Reynolds D, Flom J, Fulton L, Liao Y, Kudadjie-Gyamfi E, Terry MB (2011) Reproductive and menstrual factors and mammographic density in African American, Caribbean, and white women. Cancer Causes Control 22(4):599–610
Article PubMed PubMed Central Google Scholar
Nguyen TL, Schmidt DF, Makalic E, Dite GS, Stone J, Apicella C, Bui M, Macinnis RJ, Odefrey F, Cawson JN et al (2013) Explaining variance in the cumulus mammographic measures that predict breast cancer risk: a twins and sisters study. Cancer Epidemiol Biomarkers Prev Publ Am Assoc Cancer Res Cospons Am Soc Prev Oncol 22(12):2395–2403
Bremnes Y, Ursin G, Bjurstam N, Rinaldi S, Kaaks R, Gram IT (2007) Endogenous sex hormones, prolactin and mammographic density in postmenopausal Norwegian women. Int J Cancer 121(11):2506–2511
Article CAS PubMed Google Scholar
Pettersson A, Graff RE, Ursin G, Santos Silva ID, McCormack V, Baglietto L, Vachon C, Bakker MF, Giles GG, Chia KS et al (2014) Mammographic density phenotypes and risk of breast cancer: a meta-analysis. J Natl Cancer Inst 106(5):dju078
Article PubMed PubMed Central Google Scholar
Bertrand KA, Eliassen AH, Hankinson SE, Rosner BA, Tamimi RM (2018) Circulating hormones and mammographic density in premenopausal women. Horm Cancer 9(2):117–127
Article CAS PubMed PubMed Central Google Scholar
Ooi BNS, Loh H, Ho PJ, Milne RL, Giles G, Gao C, Kraft P, John EM, Swerdlow A, Brenner H et al (2019) The genetic interplay between body mass index, breast size and breast cancer risk: a Mendelian randomization analysis. Int J Epidemiol 48(3):781–794
Article PubMed PubMed Central Google Scholar
Tamimi RM, Hankinson SE, Colditz GA, Byrne C (2005) Endogenous sex hormone levels and mammographic density among postmenopausal women. Cancer Epidemiol Biomarkers Prev Publ Am Assoc Cancer Res Cospons Am Soc Prev Oncol 14(11 Pt 1):2641–2647
Cauley JA, Lucas FL, Kuller LH, Stone K, Browner W, Cummings SR (1999) Elevated serum estradiol and testosterone concentrations are associated with a high risk for breast cancer. Study of Osteoporotic Fractures Research Group. Ann Intern Med 130(4 Pt 1):270–277
Article CAS PubMed Google Scholar
Key T, Appleby P, Barnes I, Reeves G, Endogenous Hormones, Breast Cancer Collaborative Group (2002) Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. J Natl Cancer Inst 94(8):606–616
Article CAS PubMed Google Scholar
Hankinson SE, Eliassen AH (2010) Circulating sex steroids and breast cancer risk in premenopausal women. Horm Cancer 1(1):2–10
Article CAS PubMed PubMed Central Google Scholar
Boyd NF, Martin LJ, Yaffe MJ, Minkin S (2006) Mammographic density: a hormonally responsive risk factor for breast cancer. J Br Menopause Soc 12(4):186–193
Warren R, Skinner J, Sala E, Denton E, Dowsett M, Folkerd E, Healey CS, Dunning A, Doody D, Ponder B et al (2006) Associations among mammographic density, circulating sex hormones, and polymorphisms in sex hormone metabolism genes in postmenopausal women. Cancer Epidemiol Biomarkers Prev Publ Am Assoc Cancer Res Cospons Am Soc Prev Oncol 15(8):1502–1508
Boyd NF, Stone J, Martin LJ, Jong R, Fishell E, Yaffe M, Hammond G, Minkin S (2002) The association of breast mitogens with mammographic densities. Br J Cancer 87(8):876–882
Article CAS PubMed PubMed Central Google Scholar
Greendale GA, Palla SL, Ursin G, Laughlin GA, Crandall C, Pike MC, Reboussin BA (2005) The association of endogenous sex steroids and sex steroid binding proteins with mammographic density: results from the Postmenopausal Estrogen/Progestin Interventions Mammographic Density Study. Am J Epidemiol 162(9):826–834
Yong M, Atkinson C, Newton KM, Aiello Bowles EJ, Stanczyk FZ, Westerlind KC, Holt VL, Schwartz SM, Leisenring WM, Lampe JW (2009) Associations between endogenous sex hormone levels and mammographic and bone densities in premenopausal women. Cancer Causes Control 20(7):1039–1053
Article PubMed PubMed Central Google Scholar
Borugian MJ, Spinelli JJ, Gordon PB, Abanto Z, Brooks-Wilson A, Pollak MN, Warren LJ, Hislop TG, Gallagher RP (2014) Fasting insulin and endogenous hormones in relation to premenopausal breast density (Canada). Cancer Causes Control 25(3):385–394
Woolcott CG, Courneya KS, Boyd NF, Yaffe MJ, McTiernan A, Brant R, Jones CA, Stanczyk FZ, Terry T, Cook LS et al (2013) Association between sex hormones, glucose homeostasis, adipokines, and inflammatory markers and mammographic density among postmenopausal women. Breast Cancer Res Treat 139(1):255–265
Article CAS PubMed Google Scholar
Gierach GL, Patel DA, Falk RT, Pfeiffer RM, Geller BM, Vacek PM, Weaver DL, Chicoine RE, Shepherd JA, Mahmoudzadeh AP et al (2015) Relationship of serum estrogens and metabolites with area and volume mammographic densities. Horm Cancer 6(2–3):107–119
Article CAS PubMed PubMed Central Google Scholar
Sprague BL, Trentham-Dietz A, Gangnon RE, Buist DSM, Burnside ES, Bowles EJA, Stanczyk FZ, Sisney GS (2011) Circulating sex hormones and mammographic breast density among postmenopausal women. Horm Cancer 2(1):62–72
Article CAS PubMed Google Scholar
Bycroft C, Freeman C, Petkova D, Band G, Elliott LT, Sharp K, Motyer A, Vukcevic D, Delaneau O, O’Connell J et al (2018) The UK Biobank resource with deep phenotyping and genomic data. Nature 562(7726):203–209
Article CAS PubMed PubMed Central Google Scholar
Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S, Buchkovich ML, Yang J et al (2015) Genetic studies of body mass index yield new insights for obesity biology. Nature 518(7538):197–206
Article CAS PubMed PubMed Central Google Scholar
Chen H, Fan S, Stone J, Thompson DJ, Douglas J, Li S, Scott C, Bolla MK, Wang Q, Dennis J et al (2022) Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci. Breast Cancer Res 24(1):27–27
Article PubMed PubMed Central Google Scholar
Ruth KS, Day FR, Tyrrell J, Thompson DJ, Wood AR, Mahajan A, Beaumont RN, Wittemans L, Martin S, Busch AS et al (2020) Using human genetics to understand the disease impacts of testosterone in men and women. Nat Med 26(2):252–258
Article CAS PubMed PubMed Central Google Scholar
Haas CB, Hsu L, Lampe JW, Wernli KJ, Lindström S (2022) Cross-ancestry genome-wide association studies of sex hormone concentrations in pre- and postmenopausal women. Endocrinology 163(4):bqac020
Article PubMed PubMed Central Google Scholar
Burgess S, Davey Smith G, Davies NM, Dudbridge F, Gill D, Glymour MM, Hartwig FP, Holmes MV, Minelli C, Relton CL, Theodoratou E (2019) Guidelines for performing Mendelian randomization investigations. Wellcome Open Res 4:186–186
Bulik-Sullivan BK, Loh P-R, Finucane HK, Ripke S, Yang J, Patterson N, Daly MJ, Price AL, Neale BM (2015) LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat Genet 47(3):291–295
Article CAS PubMed PubMed Central Google Scholar
Finucane HK, Bulik-Sullivan B, Gusev A, Trynka G, Reshef Y, Loh P-R, Anttila V, Xu H, Zang C, Farh K et al (2015) Partitioning heritability by functional annotation using genome-wide association summary statistics. Nat Genet 47(11):1228–1235
Article CAS PubMed PubMed Central Google Scholar
Zheng J, Erzurumluoglu AM, Elsworth BL, Kemp JP, Howe L, Haycock PC, Hemani G, Tansey K, Laurin C, Pourcain BS et al (2017) LDHub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis. Bioinformatics 33(2):272–279
Article CAS PubMed Google Scholar
Neale B (2019) Rapid Gwas Of Thousands Of Phenotypes For 337,000 Samples In The Uk Biobank [Internet] 2019. Available from: https://www.nealelab.is/blog/2017/7/19/rapid-gwas-of-thousands-of-phenotypes-for-337000-samples-in-the-uk-biobank
Burgess S, Small DS, Thompson SG (2017) A review of instrumental variable estimators for Mendelian randomization. Stat Methods Med Res 26(5):2333–2355
Tang B, Shi H, Alfredsson L, Klareskog L, Padyukov L, Jiang X (2021) Obesity-related traits and the development of rheumatoid arthritis: evidence from genetic data. Arthritis Rheumatol 73(2):203–211
Article CAS PubMed Google Scholar
Yavorska O, Staley J (2017) MendelianRandomization: Mendelian Randomization Package. R package version 041
Burgess S, Thompson SG (2015) Multivariable Mendelian randomization: the use of pleiotropic genetic variants to estimate causal effects. Am J Epidemiol 181(4):251–260
Article PubMed PubMed Central Google Scholar
Wong CS, Lim GH, Gao F, Jakes RW, Offman J, Chia KS, Duffy SW (2011) Mammographic density and its interaction with other breast cancer risk factors in an Asian population. Br J Cancer 104(5):871–874
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