Evaluation of markers of immunity in different metastatic immune microenvironments suggests more suppression within breast to liver metastases in breast cancer

Matikas A, Zerdes I, Lövrot J, Richard F, Sotiriou C, Bergh J et al (2019) Prognostic implications of PD-L1 expression in breast cancer: systematic review and meta-analysis of immunohistochemistry and pooled analysis of transcriptomic data. Clin Cancer Res. https://doi.org/10.1158/1078-0432.CCR-19-1131

Article  PubMed  Google Scholar 

Otoshi T, Nagano T, Tachihara M, Nishimura Y (2019) Possible biomarkers for cancer immunotherapy. Cancers (Basel). https://doi.org/10.3390/cancers11070935

Article  PubMed  Google Scholar 

Bai R, Lv Z, Xu D, Cui J (2020) Predictive biomarkers for cancer immunotherapy with immune checkpoint inhibitors. Biomark Res. https://doi.org/10.1186/s40364-020-00209-0

Article  PubMed  PubMed Central  Google Scholar 

Barroso-Sousa R, Jain E, Cohen O, Kim D, Buendia-Buendia J, Winer E et al (2020) Prevalence and mutational determinants of high tumor mutation burden in breast cancer. Ann Oncol 167:671

Google Scholar 

Xin Y, Shen G, Zheng Y, Guan Y, Huo X, Li J et al (2021) Immune checkpoint inhibitors plus neoadjuvant chemotherapy in early triple-negative breast cancer: a systematic review and meta-analysis. BMC Cancer 21:1261

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cortes J, Rugo HS, Cescon DW, Im S-A, Yusof MM, Gallardo C et al (2022) Pembrolizumab plus chemotherapy in advanced triple-negative breast cancer. N Engl J Med 387:217–226

Article  CAS  PubMed  Google Scholar 

Zou Y, Zou X, Zheng S, Tang H, Zhang L, Liu P et al (2020) Efficacy and predictive factors of immune checkpoint inhibitors in metastatic breast cancer: a systematic review and meta-analysis. Ther Adv Med Oncol. https://doi.org/10.1177/1758835920940928

Article  PubMed  PubMed Central  Google Scholar 

Zou Y, Hu X, Zheng S, Yang A, Li X, Tang H et al (2021) Discordance of immunotherapy response predictive biomarkers between primary lesions and paired metastases in tumours: a systematic review and meta-analysis. EBioMedicine 63:103137

Article  CAS  PubMed  Google Scholar 

Manson QF, Schrijver WAME, ter Hoeve ND, Moelans CB, van Diest PJ (2019) Frequent discordance in PD-1 and PD-L1 expression between primary breast tumors and their matched distant metastases. Clin Exp Metastasis 36:29–37

Article  CAS  PubMed  Google Scholar 

Boman C, Zerdes I, Mårtensson K, Bergh J, Foukakis T, Valachis A et al (2021) Discordance of PD-L1 status between primary and metastatic breast cancer: a systematic review and meta-analysis. Cancer Treat Rev 99:102257

Article  CAS  PubMed  Google Scholar 

Chung W, Eum HH, Lee H-O, Lee K-M, Lee H-B, Kim K-T et al (2017) Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer. Nat Commun. https://doi.org/10.1038/ncomms15081

Article  PubMed  PubMed Central  Google Scholar 

Zhao X, Qu J, Sun Y, Wang J, Liu X, Wang F et al (2017) Prognostic significance of tumor-associated macrophages in breast cancer: a meta-analysis of the literature. Oncotarget 5:46

Google Scholar 

Mahmoud SMA, Lee AHS, Paish EC, Macmillan RD, Ellis IO, Green AR (2012) Tumour-infiltrating macrophages and clinical outcome in breast cancer. J Clin Pathol. https://doi.org/10.1136/jclinpath-2011-200355

Article  PubMed  Google Scholar 

Noske A, Wagner D-C, Schwamborn K, Foersch S, Steiger K, Kiechle M et al (2021) 13P Comparison study of different programmed death-ligand 1 (PD-L1) assays, readers and scoring methods in triple-negative breast cancer (TNBC). Ann Oncol 32:S26

Article  Google Scholar 

Hong M, Kim JW, Kyoon Kim M, Wha Chung B, Kyung Ahn S (2020) Programmed cell death-ligand 1 expression in stromal immune cells is a marker of breast cancer outcome. J Cancer 11:7246–7252

Article  PubMed  PubMed Central  Google Scholar 

Zhang M, Sun H, Zhao S, Wang Y, Pu H, Wang Y et al (2017) Expression of PD-L1 and prognosis in breast cancer: a meta-analysis. Oncotarget 8:31347–31354

Article  PubMed  PubMed Central  Google Scholar 

Szekely B, Bossuyt V, Li X, Wali VB, Patwardhan GA, Frederick C et al (2018) Immunological differences between primary and metastatic breast cancer. Ann Oncol. https://doi.org/10.1093/annonc/mdy399

Article  PubMed  PubMed Central  Google Scholar 

Abad MN, Calabuig-Fariñas S, de Mena ML, Torres-Martínez S, González CG, García JÁG et al (2022) Programmed death-ligand 1 (PD-L1) as immunotherapy biomarker in breast cancer. Cancers (Basel) 14:307

Article  Google Scholar 

Lee H, Na KJ, Choi H (2021) Differences in tumor immune microenvironment in metastatic sites of breast cancer. Front Oncol. https://doi.org/10.3389/fonc.2021.649004

Article  PubMed  PubMed Central  Google Scholar 

Hilbers F, Venet D, Agostinetto E, Benelli M, Guerrero A, Martins-Branco D et al (2023) Characterization of the immune microenvironment in matched primary and metastatic breast cancer lesions from the AURORA study: BIG 14–01. J Clin Oncol 41:1009

Article  Google Scholar 

Bale R, Putzer D, Schullian P (2019) Local treatment of breast cancer liver metastasis. Cancers (Basel) 11:1341

Article  CAS  PubMed  Google Scholar 

Adam R, Aloia T, Krissat J, Bralet M-P, Paule B, Giacchetti S et al (2006) Is Liver resection justified for patients with hepatic metastases from breast cancer? Ann Surg 244:897–908

Article  PubMed  PubMed Central  Google Scholar 

Philip PA, Azar I, Xiu J, Hall MJ, Hendifar AE, Lou E et al (2022) Molecular characterization of KRAS wild-type tumors in patients with pancreatic adenocarcinoma. Clin Cancer Res 28:2704–2714

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marabelle A, Fakih M, Lopez J, Shah M, Shapira-Frommer R, Nakagawa K et al (2020) Association of tumour mutational burden with outcomes in patients with advanced solid tumours treated with pembrolizumab: prospective biomarker analysis of the multicohort, open-label, phase 2 KEYNOTE-158 study. Lancet Oncol 21:1353–1365

Article  CAS  PubMed  Google Scholar 

Finotello F, Mayer C, Plattner C, Laschober G, Rieder D, Hackl H et al (2019) Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data. Genome Med. https://doi.org/10.1186/s13073-019-0655-5

Article  PubMed  PubMed Central  Google Scholar 

Becht E, Giraldo NA, Lacroix L, Buttard B, Elarouci N, Petitprez F et al (2016) Estimating the population abundance of tissue-infiltrating immune and stromal cell populations using gene expression. Genome Biol 17:218

Article  PubMed  PubMed Central  Google Scholar 

Sidiropoulos DN, Rafie CI, Jang JK, Castanon S, Baugh AG, Gonzalez E et al (2022) Entinostat decreases immune suppression to promote antitumor responses in a HER2+ breast tumor microenvironment. Cancer Immunol Res 10:656–669

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sidiropoulos DN, Rafie CI, Jang JK, Castanon S, Baugh AG, Gonzalez E et al (2022) Entinostat decreases immune suppression to promote antitumor responses in a HER2+ breast tumor microenvironment. Cancer Immunol Res Cancer Immunol Res 10:656–669

Article  CAS  PubMed  Google Scholar 

Zhang W, Kong X, Ai B, Wang Z, Wang X, Wang N et al (2021) Research progresses in immunological checkpoint inhibitors for breast cancer immunotherapy. Front Oncol. https://doi.org/10.3389/fonc.2021.582664

Article  PubMed  PubMed Central  Google Scholar 

Bao R, Stapor D, Luke JJ (2020) Molecular correlates and therapeutic targets in T cell-inflamed versus non-T cell-inflamed tumors across cancer types. Genome Med. https://doi.org/10.1186/s13073-020-00787-6

Article  PubMed  PubMed Central  Google Scholar 

Schnidrig D, Turajlic S, Litchfield K (2019) Tumour mutational burden: primary versus metastatic tissue creates systematic bias. Immuno-oncol Technol 4:8–14

Article  Google Scholar 

Tumeh PC, Hellmann MD, Hamid O, Tsai KK, Loo KL, Gubens MA et al (2017) Liver metastasis and treatment outcome with anti-PD-1 monoclonal antibody in patients with melanoma and NSCLC. Cancer Immunol Res 5:417–424

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schurich A, Berg M, Stabenow D, Böttcher J, Kern M, Schild H-J et al (2010) Dynamic regulation of CD8 T cell tolerance induction by liver sinusoidal endothelial cells. J Immunol 184:4107–4114

Article  CAS  PubMed  Google Scholar 

Kaczmarek J, Homsi Y, van Üüm J, Metzger C, Knolle PA, Kolanus W et al (2014) Liver sinusoidal endothelial cell-mediated cd8 t cell priming depends on co-inhibitory signal integration over time. PLoS ONE 9:e99574

Article  PubMed  PubMed Central  Google Scholar 

Schildberg FA, Hegenbarth SI, Schumak B, Limmer A, Knolle PA (2008) Liver sinusoidal endothelial cells veto CD8 T cell activation by antigen-presenting dendritic cells. Eur J Immunol 38:957–967

Article  CAS  PubMed  Google Scholar 

Oh E, Hong J, Yun C-O (2019) Regulatory T cells induce metastasis by increasing Tgf-β and enhancing the epithelial-mesenchymal transition. Cells 8:1387

Article  CAS  PubMed  PubMed Central 

留言 (0)

沒有登入
gif