Adachi J, Mishima K, Wakiya K, Suzuki T, Fukuoka K, Yanagisawa T, Matsutani M, Sasaki A, Nishikawa R (2012) O6-methylguanine-DNA methyltransferase promoter methylation in 45 primary central nervous system lymphomas: quantitative assessment of methylation and response to temozolomide treatment. J Neurooncol 107:147–153. https://doi.org/10.1007/s11060-011-0721-3

Article  CAS  PubMed  Google Scholar 

Bacci M, Lorito N, Ippolito L, Ramazzotti M, Luti S, Romagnoli S, Parri M, Bianchini F, Cappellesso F, Virga F, Gao Q, Simões BM, Marangoni E, Martin LA, Comito G, Ferracin M, Giannoni E, Mazzone M, Chiarugi P, Morandi A (2019) Reprogramming of amino acid transporters to support aspartate and glutamate dependency sustains endocrine resistance in breast cancer. Cell Rep 28:104-118.e108. https://doi.org/10.1016/j.celrep.2019.06.010

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bai H, Harmancı AS, Erson-Omay EZ, Li J, Coşkun S, Simon M, Krischek B, Özduman K, Omay SB, Sorensen EA, Turcan Ş, Bakırcığlu M, Carrión-Grant G, Murray PB, Clark VE, Ercan-Sencicek AG, Knight J, Sencar L, Altınok S, Kaulen LD, Gülez B, Timmer M, Schramm J, Mishra-Gorur K, Henegariu O, Moliterno J, Louvi A, Chan TA, Tannheimer SL, Pamir MN, Vortmeyer AO, Bilguvar K, Yasuno K, Günel M (2016) Integrated genomic characterization of IDH1-mutant glioma malignant progression. Nat Genet 48:59–66. https://doi.org/10.1038/ng.3457

Article  CAS  PubMed  Google Scholar 

Baylin SB, Herman JG (2000) DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet 16:168–174. https://doi.org/10.1016/s0168-9525(99)01971-x

Article  CAS  PubMed  Google Scholar 

Baylin SB, Jones PA (2016) Epigenetic determinants of cancer. Cold Spring Harb Perspect Biol. https://doi.org/10.1101/cshperspect.a019505

Article  PubMed  PubMed Central  Google Scholar 

Brennan CW, Verhaak RG, McKenna A, Campos B, Noushmehr H, Salama SR, Zheng S, Chakravarty D, Sanborn JZ, Berman SH, Beroukhim R, Bernard B, Wu CJ, Genovese G, Shmulevich I, Barnholtz-Sloan J, Zou L, Vegesna R, Shukla SA, Ciriello G, Yung WK, Zhang W, Sougnez C, Mikkelsen T, Aldape K, Bigner DD, Van Meir EG, Prados M, Sloan A, Black KL, Eschbacher J, Finocchiaro G, Friedman W, Andrews DW, Guha A, Iacocca M, O’Neill BP, Foltz G, Myers J, Weisenberger DJ, Penny R, Kucherlapati R, Perou CM, Hayes DN, Gibbs R, Marra M, Mills GB, Lander E, Spellman P, Wilson R, Sander C, Weinstein J, Meyerson M, Gabriel S, Laird PW, Haussler D, Getz G, Chin L, Network TR (2013) The somatic genomic landscape of glioblastoma. Cell 155:462–477. https://doi.org/10.1016/j.cell.2013.09.034

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cadieux B, Ching TT, VandenBerg SR, Costello JF (2006) Genome-wide hypomethylation in human glioblastomas associated with specific copy number alteration, methylenetetrahydrofolate reductase allele status, and increased proliferation. Cancer Res 66:8469–8476. https://doi.org/10.1158/0008-5472.CAN-06-1547

Article  CAS  PubMed  Google Scholar 

Ceccarelli M, Barthel FP, Malta TM, Sabedot TS, Salama SR, Murray BA, Morozova O, Newton Y, Radenbaugh A, Pagnotta SM, Anjum S, Wang J, Manyam G, Zoppoli P, Ling S, Rao AA, Grifford M, Cherniack AD, Zhang H, Poisson L, Carlotti CG, Tirapelli DP, Rao A, Mikkelsen T, Lau CC, Yung WK, Rabadan R, Huse J, Brat DJ, Lehman NL, Barnholtz-Sloan JS, Zheng S, Hess K, Rao G, Meyerson M, Beroukhim R, Cooper L, Akbani R, Wrensch M, Haussler D, Aldape KD, Laird PW, Gutmann DH, Noushmehr H, Iavarone A, Verhaak RG, Network TR (2016) Molecular profiling reveals biologically discrete subsets and pathways of progression in diffuse glioma. Cell 164:550–563. https://doi.org/10.1016/j.cell.2015.12.028

Article  CAS  PubMed  PubMed Central  Google Scholar 

Du J, Johnson LM, Jacobsen SE, Patel DJ (2015) DNA methylation pathways and their crosstalk with histone methylation. Nat Rev Mol Cell Biol 16:519–532. https://doi.org/10.1038/nrm4043

Article  CAS  PubMed  PubMed Central  Google Scholar 

Garcia-Bermudez J, Baudrier L, La K, Zhu XG, Fidelin J, Sviderskiy VO, Papagiannakopoulos T, Molina H, Snuderl M, Lewis CA, Possemato RL, Birsoy K (2018) Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours. Nat Cell Biol 20:775–781. https://doi.org/10.1038/s41556-018-0118-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Greenberg MVC, Bourc’his D (2019) The diverse roles of DNA methylation in mammalian development and disease. Nat Rev Mol Cell Biol 20:590–607. https://doi.org/10.1038/s41580-019-0159-6

Article  CAS  PubMed  Google Scholar 

Gu Y, Albuquerque CP, Braas D, Zhang W, Villa GR, Bi J, Ikegami S, Masui K, Gini B, Yang H, Gahman TC, Shiau AK, Cloughesy TF, Christofk HR, Zhou H, Guan KL, Mischel PS (2017) mTORC2 regulates amino acid metabolism in cancer by phosphorylation of the cystine-glutamate antiporter xCT. Mol Cell 67:128-138.e127. https://doi.org/10.1016/j.molcel.2017.05.030

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guillem AM, Krizman EN, Robinson MB (2022) Rapid regulation of glutamate transport: where do we go from here? Neurochem Res 47:61–84. https://doi.org/10.1007/s11064-021-03329-7

Article  CAS  PubMed  Google Scholar 

Harachi M, Masui K, Cavenee WK, Mischel PS, Shibata N (2021) Protein acetylation at the interface of genetics, epigenetics and environment in cancer. Metabolites. https://doi.org/10.3390/metabo11040216

Article  PubMed  PubMed Central  Google Scholar 

Harachi M, Masui K, Honda H, Muragaki Y, Kawamata T, Cavenee WK, Mischel PS, Shibata N (2020) Dual regulation of histone methylation by mTOR complexes controls glioblastoma tumor cell growth via EZH2 and SAM. Mol Cancer Res 18:1142–1152. https://doi.org/10.1158/1541-7786.MCR-20-0024

Article  CAS  PubMed  Google Scholar 

Hervouet E, Vallette FM, Cartron PF (2009) Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation. Epigenetics 4:487–499. https://doi.org/10.4161/epi.4.7.9883

Article  CAS  PubMed  Google Scholar 

Klughammer J, Kiesel B, Roetzer T, Fortelny N, Nemc A, Nenning KH, Furtner J, Sheffield NC, Datlinger P, Peter N, Nowosielski M, Augustin M, Mischkulnig M, Ströbel T, Alpar D, Ergüner B, Senekowitsch M, Moser P, Freyschlag CF, Kerschbaumer J, Thomé C, Grams AE, Stockhammer G, Kitzwoegerer M, Oberndorfer S, Marhold F, Weis S, Trenkler J, Buchroithner J, Pichler J, Haybaeck J, Krassnig S, Mahdy Ali K, von Campe G, Payer F, Sherif C, Preiser J, Hauser T, Winkler PA, Kleindienst W, Würtz F, Brandner-Kokalj T, Stultschnig M, Schweiger S, Dieckmann K, Preusser M, Langs G, Baumann B, Knosp E, Widhalm G, Marosi C, Hainfellner JA, Woehrer A, Bock C (2018) The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space. Nat Med 24:1611–1624. https://doi.org/10.1038/s41591-018-0156-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lange F, Weßlau K, Porath K, Hörnschemeyer J, Bergner C, Krause BJ, Mullins CS, Linnebacher M, Köhling R, Kirschstein T (2019) AMPA receptor antagonist perampanel affects glioblastoma cell growth and glutamate release in vitro. PLoS ONE 14:e0211644. https://doi.org/10.1371/journal.pone.0211644

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Y, Chen X, Lu C (2021) The interplay between DNA and histone methylation: molecular mechanisms and disease implications. EMBO Rep 22:e51803. https://doi.org/10.15252/embr.202051803

Article  CAS  PubMed  PubMed Central  Google Scholar 

Masui K, Cavenee WK, Mischel PS, Shibata N (2022) The metabolomic landscape plays a critical role in glioma oncogenesis. Cancer Sci 113:1555–1563. https://doi.org/10.1111/cas.15325

Article  CAS  PubMed  PubMed Central  Google Scholar 

Masui K, Harachi M, Ikegami S, Yang H, Onizuka H, Yong WH, Cloughesy TF, Muragaki Y, Kawamata T, Arai N, Komori T, Cavenee WK, Mischel PS, Shibata N (2019) mTORC2 links growth factor signaling with epigenetic regulation of iron metabolism in glioblastoma. J Biol Chem 294:19740–19751. https://doi.org/10.1074/jbc.RA119.011519

Article  CAS  PubMed  PubMed Central  Google Scholar 

Masui K, Harachi M, Cavenee WK, Mischel PS, Shibata N (2020) Codependency of metabolism and epigenetics drives cancer progression: a review. Acta Histochem Cytochem 53:1–10. https://doi.org/10.1267/ahc.20002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Masui K, Mischel PS (2023) Metabolic and epigenetic reprogramming in the pathogenesis of glioblastoma: toward the establishment of “metabolism-based pathology.” Pathol Int. https://doi.org/10.1111/pin.13379

Article  PubMed  Google Scholar 

Masui K, Suzuki SO, Torisu R, Goldman JE, Canoll P, Iwaki T (2010) Glial progenitors in the brainstem give rise to malignant gliomas by platelet-derived growth factor stimulation. Glia 58:1050–1065. https://doi.org/10.1002/glia.20986

Article  PubMed  Google Scholar 

Mortimer T, Wainwright EN, Patel H, Siow BM, Jaunmuktane Z, Brandner S, Scaffidi P (2019) Redistribution of EZH2 promotes malignant phenotypes by rewiring developmental programmes. EMBO Rep 20:e48155. https://doi.org/10.15252/embr.201948155

Article  CAS  PubMed  PubMed Central  Google Scholar 

Network CGAR (2008) Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455:1061–1068. https://doi.org/10.1038/nature07385

Article  CAS  Google Scholar 

Nomura M, Saito K, Aihara K, Nagae G, Yamamoto S, Tatsuno K, Ueda H, Fukuda S, Umeda T, Tanaka S, Takayanagi S, Otani R, Nejo T, Hana T, Takahashi S, Kitagawa Y, Omata M, Higuchi F, Nakamura T, Muragaki Y, Narita Y, Nagane M, Nishikawa R, Ueki K, Saito N, Aburatani H, Mukasa A (2019) DNA demethylation is associated with malignant progression of lower-grade gliomas. Sci Rep 9:1903. https://doi.org/10.1038/s41598-019-38510-0

Article  ADS  CAS  PubMed  PubMed Central