Real-world characteristics and use patterns of patients treated with vericiguat: A nationwide longitudinal cohort study in Germany

Dörr M, Riemer U, Christ M, Bauersachs J, Bosch R, Laufs U, Neumann A, Scherer M, Störk S, Wachter R (2021) Hospitalizations for heart failure: still major differences between East and West Germany 30 years after reunification. ESC Heart Fail 8(4):2546–2555. https://doi.org/10.1002/ehf2.13407

Article  Google Scholar 

Metra M, Tomasoni D, Adamo M, Bayes-Genis A, Filippatos G, Abdelhamid M, Adamopoulos S, Anker SD, Antohi L, Böhm M, Braunschweig F, Gal TB, Butler J, Cleland JGF, Cohen-Solal A, Damman K, Gustafsson F, Hill L, Jankowska EA, Lainscak M, Lund LH, McDonagh T, Mebazaa A, Moura B, Mullens W, Piepoli M, Ponikowski P, Rakisheva A, Ristic A, Savarese G, Seferovic P, Sharma R, Tocchetti CG, Yilmaz MB, Vitale C, Volterrani M, Von Haehling S, Chioncel O, Coats AJS, Rosano G (2023) Worsening of chronic heart failure: definition, epidemiology, management and prevention A clinical consensus statement by the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail 25(6):776–791. https://doi.org/10.1002/ejhf.2874

Article  Google Scholar 

Bauersachs J (2021) Heart failure drug treatment: the fantastic four. Eur Heart J 42(6):681–683. https://doi.org/10.1093/eurheartj/ehaa1012

Article  Google Scholar 

Scholte NTB, Gürgöze MT, Aydin D, Theuns DAMJ, Manintveld OC, Ronner E, Boersma E, de Boer RA, van der Boon RMA, Brugts JJ (2023) Telemonitoring for heart failure: a meta-analysis. Eur Heart J 44(31):2911–2926. https://doi.org/10.1093/eurheartj/ehad280

Article  Google Scholar 

Kerwagen F, Koehler K, Vettorazzi E, Stangl V, Koehler M, Halle M, Koehler F, Störk S (2023) Remote patient management of heart failure across the ejection fraction spectrum: A pre-specified analysis of the TIM-HF2 trial. Eur J Heart Fail 25(9):1671–1681. https://doi.org/10.1002/ejhf.2948

Article  Google Scholar 

McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Bohm M, Burri H, Butler J, Celutkiene J, Chioncel O, Cleland JGF, Coats AJS, Crespo-Leiro MG, Farmakis D, Gilard M, Heymans S, Hoes AW, Jaarsma T, Jankowska EA, Lainscak M, Lam CSP, Lyon AR, McMurray JJV, Mebazaa A, Mindham R, Muneretto C, Francesco Piepoli M, Price S, Rosano GMC, Ruschitzka F, Kathrine Skibelund A (2021) 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J 42(36):3599–3726. https://doi.org/10.1093/eurheartj/ehab368

Article  CAS  Google Scholar 

McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, Burri H, Butler J, Čelutkienė J, Chioncel O, Cleland JGF, Crespo-Leiro MG, Farmakis D, Gilard M, Heymans S, Hoes AW, Jaarsma T, Jankowska EA, Lainscak M, Lam CSP, Lyon AR, McMurray JJV, Mebazaa A, Mindham R, Muneretto C, Francesco Piepoli M, Price S, Rosano GMC, Ruschitzka F, Skibelund AK, and Group ESD (2023) 2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. https://doi.org/10.1093/eurheartj/ehad195

Article  Google Scholar 

Armstrong PW, Pieske B, Anstrom KJ, Ezekowitz J, Hernandez AF, Butler J, Lam CSP, Ponikowski P, Voors AA, Jia G, McNulty SE, Patel MJ, Roessig L, Koglin J, O’Connor CM (2020) Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction. N Engl J Med 382(20):1883–1893. https://doi.org/10.1056/NEJMoa1915928

Article  CAS  Google Scholar 

Seferović PM, Polovina M, Adlbrecht C, Bělohlávek J, Chioncel O, Goncalvesová E, Milinković I, Grupper A, Halmosi R, Kamzola G, Koskinas KC, Lopatin Y, Parkhomenko A, Põder P, Ristić AD, Šakalytė G, Trbušić M, Tundybayeva M, Vrtovec B, Yotov YT, Miličić D, Ponikowski P, Metra M, Rosano G, Coats AJS (2021) Navigating between Scylla and Charybdis: challenges and strategies for implementing guideline-directed medical therapy in heart failure with reduced ejection fraction. Eur J Heart Fail 23(12):1999–2007. https://doi.org/10.1002/ejhf.2378

Article  Google Scholar 

Kerwagen F, Riemer U, Wachter R, von Haehling S, Abdin A, Böhm M, Schulz M, Störk S (2023) Impact of the COVID-19 pandemic on implementation of novel guideline-directed medical therapies for heart failure in Germany: a nationwide retrospective analysis. Lancet Reg Health Eur 35:10078. https://doi.org/10.1016/j.lanepe.2023.100778

Article  Google Scholar 

Agewall S (2021) Adherence to pharmacological treatment: how can we improve? Eur Heart J Cardiovasc Pharmacother 7(4):261–262. https://doi.org/10.1093/ehjcvp/pvab049

Article  Google Scholar 

Ferdinand KC, Senatore FF, Clayton-Jeter H, Cryer DR, Lewin JC, Nasser SA, Fiuzat M, Califf RM (2017) Improving Medication Adherence in Cardiometabolic Disease: Practical and Regulatory Implications. J Am Coll Cardiol 69(4):437–451. https://doi.org/10.1016/j.jacc.2016.11.034

Article  Google Scholar 

Rasmussen AA, Wiggers H, Jensen M, Berg SK, Rasmussen TB, Borregaard B, Thrysoee L, Thorup CB, Mols RE, Larsen SH, Johnsen SP (2021) Patient-reported outcomes and medication adherence in patients with heart failure. Eur Heart J Cardiovasc Pharmacother 7(4):287–295. https://doi.org/10.1093/ehjcvp/pvaa097

Article  Google Scholar 

Larsson JE, Denholt CS, Thune JJ, Raja AA, Fosbøl E, Schou M, Køber L, Nielsen OW, Gustafsson F, Kristensen SL (2023) Initiation of eplerenone or spironolactone, treatment adherence, and associated outcomes in patients with new-onset heart failure with reduced ejection fraction: a nationwide cohort study. Eur Heart J Cardiovasc Pharmacother 9(6):546–552. https://doi.org/10.1093/ehjcvp/pvad045

Article  Google Scholar 

Qin X, Hung J, Knuiman MW, Briffa TG, Teng TK, Sanfilippo FM (2023) Evidence-based medication adherence among seniors in the first year after heart failure hospitalisation and subsequent long-term outcomes: a restricted cubic spline analysis of adherence-outcome relationships. Eur J Clin Pharmacol 79(4):553–567. https://doi.org/10.1007/s00228-023-03467-7

Article  CAS  Google Scholar 

European Medicines Agency (2021) European public assessment report. Verquvo. https://www.ema.europa.eu/en/medicines/human/EPAR/verquvo. Accessed 17 Jan 2024

Richter H, Dombrowski S, Hamer H, Hadji P, Kostev K (2015) Use of a German longitudinal prescription database (LRx) in pharmacoepidemiology. Ger Med Sci 13:Doc14. https://doi.org/10.3205/000218

Article  Google Scholar 

Karve S, Cleves MA, Helm M, Hudson TJ, West DS, Martin BC (2009) Good and poor adherence: optimal cut-point for adherence measures using administrative claims data. Curr Med Res Opin 25(9):2303–2310. https://doi.org/10.1185/03007990903126833

Article  Google Scholar 

Carnicelli AP, Li Z, Greiner MA, Lippmann SJ, Greene SJ, Mentz RJ, Hardy NC, Blumer V, Shen X, Yancy CW, Peterson PN, Allen LA, Fonarow GC, O’Brien EC (2021) JACC Heart Fail 9(12):876–886. https://doi.org/10.1016/j.jchf.2021.06.018

Article  Google Scholar 

Tahhan AS, Vaduganathan M, Greene SJ, Fonarow GC, Fiuzat M, Jessup M, Lindenfeld J, O’Connor CM, Butler J (2018) Enrollment of Older Patients, Women, and Racial and Ethnic Minorities in Contemporary Heart Failure Clinical Trials: A Systematic Review. JAMA Cardiol 3(10):1011–1019. https://doi.org/10.1001/jamacardio.2018.2559

Article  Google Scholar 

Nguyen NV, Lindberg F, Benson L, Ferrannini G, Imbalzano E, Mol PGM, Dahlström U, Rosano GMC, Ezekowitz J, Butler J, Lund LH, Savarese G (2023) Eligibility for vericiguat in a real-world heart failure population according to trial, guideline and label criteria: Data from the Swedish Heart Failure Registry. Eur J Heart Fail 25(8):1418–1428. https://doi.org/10.1002/ejhf.2939

Article  CAS  Google Scholar 

Agarwal A, Peters SAE, Chandramouli C, Lam CSP, Figtree GA, Arnott C (2021) Guideline-Directed Medical Therapy in Females with Heart Failure with Reduced Ejection Fraction. Curr Heart Fail Rep 18(5):284–289. https://doi.org/10.1007/s11897-021-00524-z

Article  Google Scholar 

Seo W-W, Park JJ, Park HA, Cho H-J, Lee H-Y, Kim KH, Yoo B-S, Kang S-M, Baek SH, Jeon E-S, Kim J-J, Cho M-C, Chae SC, Oh B-H, Choi D-J (2020) Guideline-directed medical therapy in elderly patients with heart failure with reduced ejection fraction: a cohort study. BMJ Open 10(2):e030514. https://doi.org/10.1136/bmjopen-2019-030514

Article  Google Scholar 

Savarese G, Kishi T, Vardeny O, Adamsson Eryd S, Bodegård J, Lund LH, Thuresson M, Bozkurt B (2023) Heart Failure Drug Treatment—Inertia, Titration, and Discontinuation: A Multinational Observational Study (EVOLUTION HF). JACC Heart Fail 11(1):1–14. https://doi.org/10.1016/j.jchf.2022.08.009

Article  Google Scholar 

Norberg H, Pranic V, Bergdahl E, Lindmark K (2020) Differences in medical treatment and clinical characteristics between men and women with heart failure - a single-centre multivariable analysis. Eur J Clin Pharmacol 76(4):539–546. https://doi.org/10.1007/s00228-019-02782-2

Article  CAS  Google Scholar 

Ødegaard KM, Lirhus SS, Melberg HO, Hallén J, Halvorsen S (2023) Adherence and persistence to pharmacotherapy in patients with heart failure: a nationwide cohort study, 2014–2020. ESC Heart Fail 10(1):405–415. https://doi.org/10.1002/ehf2.14206

Article  Google Scholar 

Bhatt AS, Vaduganathan M, Solomon SD, Schneeweiss S, Lauffenburger JC, Desai RJ (2022) Sacubitril/valsartan use patterns among older adults with heart failure in clinical practice: a population-based cohort study of >25 000 Medicare beneficiaries. Eur J Heart Fail 24(9):1506–1515. https://doi.org/10.1002/ejhf.2572

Article  CAS  Google Scholar 

Wachter R, Fonseca AF, Balas B, Kap E, Engelhard J, Schlienger R, Klebs S, Wirta SB, Kostev K (2019) Real-world treatment patterns of sacubitril/valsartan: a longitudinal cohort study in Germany. Eur J Heart Fail 21(5):588–597. https://doi.org/10.1002/ejhf.1465

Article  CAS  Google Scholar 

Aziz H, Gouda P, Sharma A (2021) Vericiguat in the management of heart failure with reduced ejection fraction. Eur Heart J Cardiovasc Pharmacother 7(4):e65–e66. https://doi.org/10.1093/ehjcvp/pvab022

Article  Google Scholar 

Lam CSP, Mulder H, Lopatin Y, Vazquez-Tanus JB, Siu D, Ezekowitz J, Pieske B, O’Connor CM, Roessig L, Patel MJ, Anstrom KJ, Hernandez AF, Armstrong PW (2021) Blood Pressure and Safety Events With Vericiguat in the VICTORIA Trial. J Am Heart Assoc 10(22):e021094. https://doi.org/10.1161/jaha.121.021094

Article  CAS  Google Scholar 

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