Hwang, C. D. et al. Contemporary perspectives on heterotopic ossification. JCI Insight 7, e158996 (2022).
Article PubMed PubMed Central Google Scholar
Kaplan, F. S. & Shore, E. M. Progressive osseous heteroplasia. J. Bone Miner. Res. 15, 2084–2094 (2000).
Article CAS PubMed Google Scholar
Peterson, J. R. et al. Effects of aging on osteogenic response and heterotopic ossification following burn injury in mice. Stem Cells Dev. 24, 205–213 (2015).
Article CAS PubMed Google Scholar
Spreadborough, P. J., Strong, A. L., Mares, J., Levi, B. & Davis, T. A. Tourniquet use following blast-associated complex lower limb injury and traumatic amputation promotes end organ dysfunction and amplified heterotopic ossification formation. JOSR 17, 422 (2022).
Wiesener, M. S. et al. Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs. FASEB J. 17, 271–273 (2003).
Article CAS PubMed Google Scholar
Pugh, C. W. & Ratcliffe, P. J. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat. Med. 9, 677–684 (2003).
Article CAS PubMed Google Scholar
Amarilio, R. et al. HIF1alpha regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis. Development 134, 3917–3928 (2007).
Article CAS PubMed Google Scholar
Provot, S. et al. Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development. J. Cell Biol. 177, 451–464 (2007).
Article CAS PubMed PubMed Central Google Scholar
Agarwal, S. et al. Inhibition of Hif1alpha prevents both trauma-induced and genetic heterotopic ossification. Proc. Natl. Acad. Sci. USA 113, E338–E347 (2016).
Article CAS PubMed Google Scholar
Gilkes, D. M., Bajpai, S., Chaturvedi, P., Wirtz, D. & Semenza, G. L. Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts. J. Biol. Chem. 288, 10819–10829 (2013).
Article CAS PubMed PubMed Central Google Scholar
Myllyharju, J. & Kivirikko, K. I. Collagens, modifying enzymes and their mutations in humans, flies and worms. Trends Genet. 20, 33–43 (2004).
Article CAS PubMed Google Scholar
van der Slot, A. J. et al. Identification of PLOD2 as telopeptide lysyl hydroxylase, an important enzyme in fibrosis. J. Biol. Chem. 278, 40967–40972 (2003).
Vallet, S. D. & Ricard-Blum, S. Lysyl oxidases: from enzyme activity to extracellular matrix cross-links. Essays Biochem. 63, 349–364 (2019).
Article CAS PubMed Google Scholar
van der Slot, A. J. et al. Elevated formation of pyridinoline cross-links by profibrotic cytokines is associated with enhanced lysyl hydroxylase 2b levels. Biochim. Biophys. Acta 1741, 95–102 (2005).
Wells, R. G. The role of matrix stiffness in regulating cell behavior. Hepatology 47, 1394–1400 (2008).
Article CAS PubMed Google Scholar
Huang, Y., Lin, D. & Taniguchi, C. M. Hypoxia inducible factor (HIF) in the tumor microenvironment: friend or foe? Sci. China Life Sci. 60, 1114–1124 (2017).
Article CAS PubMed PubMed Central Google Scholar
Missiaen, R., Lesner, N. P. & Simon, M. C. HIF: a master regulator of nutrient availability and metabolic cross-talk in the tumor microenvironment. EMBO J. 42, e112067 (2023).
Article CAS PubMed PubMed Central Google Scholar
Huber, A. K. et al. Immobilization after injury alters extracellular matrix and stem cell fate. J. Clin. Investig. 130, 5444–5460 (2020).
Article CAS PubMed PubMed Central Google Scholar
Pagani, C. A. et al. Discoidin domain receptor 2 regulates aberrant mesenchymal lineage cell fate and matrix organization. Sci. Adv. 8, eabq6152 (2022).
Article ADS CAS PubMed PubMed Central Google Scholar
Peterson, J. R. et al. Direct mouse trauma/burn model of heterotopic ossification. J. Vis. Exp. 102, e52880 (2015).
Davis, A. P., Witte, D. P., Hsieh-Li, H. M., Potter, S. S. & Capecchi, M. R. Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11. Nature 375, 791–795 (1995).
Article ADS CAS PubMed Google Scholar
Pineault, K. M., Song, J. Y., Kozloff, K. M., Lucas, D. & Wellik, D. M. Hox11 expressing regional skeletal stem cells are progenitors for osteoblasts, chondrocytes and adipocytes throughout life. Nat. Commun. 10, 3168 (2019).
Article ADS PubMed PubMed Central Google Scholar
Rux, D., Helbig, K., Koyama, E. & Pacifici, M. Hox11 expression characterizes developing zeugopod synovial joints and is coupled to postnatal articular cartilage morphogenesis into functional zones in mice. Dev. Biol. 477, 49–63 (2021).
Article CAS PubMed PubMed Central Google Scholar
Pagani, C. A. et al. Novel lineage-tracing system to identify site-specific ectopic bone precursor cells. Stem Cell Rep. 16, 626–640 (2021).
Huang, Y. & Kyriakides, T. R. The role of extracellular matrix in the pathophysiology of diabetic wounds. Matrix Biol. 6-7, 100037 (2020).
Gilkes, D. M., Semenza, G. L. & Wirtz, D. Hypoxia and the extracellular matrix: drivers of tumour metastasis. Nat. Rev. Cancer 14, 430–439 (2014).
Article CAS PubMed PubMed Central Google Scholar
Qi, Y. & Xu, R. Roles of PLODs in collagen synthesis and cancer progression. Front. Cell Dev. Biol. 6, 66 (2018).
Article PubMed PubMed Central Google Scholar
Tong, Y. et al. The PLOD2/succinate axis regulates the epithelial-mesenchymal plasticity and cancer cell stemness. Proc. Natl. Acad. Sci. USA 120, e2214942120 (2023).
Article CAS PubMed PubMed Central Google Scholar
Cho, Y. et al. CTRP3 exacerbates tendinopathy by dysregulating tendon stem cell differentiation and altering extracellular matrix composition. Sci. Adv. 7, eabg6069 (2021).
Article ADS CAS PubMed PubMed Central Google Scholar
Riley, G. Tendinopathy-from basic science to treatment. Nat. Clin. Pract. Rheumatol. 4, 82–89 (2008).
Gilkes, D. M. et al. Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis. Mol. Cancer Res. 11, 456–466 (2013).
Article CAS PubMed PubMed Central Google Scholar
Semenza, G. L. The hypoxic tumor microenvironment: a driving force for breast cancer progression. Biochim. Biophys. Acta 1863, 382–391 (2016).
Article CAS PubMed Google Scholar
Wang, H. et al. Cellular hypoxia promotes heterotopic ossification by amplifying BMP signaling. J. Bone Min. Res. 31, 1652–1665 (2016).
Jaakkola, P. et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292, 468–472 (2001).
Article ADS CAS PubMed Google Scholar
Ivan, M. et al. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292, 464–468 (2001).
Article ADS CAS PubMed Google Scholar
van der Slot, A. J. et al. Increased formation of pyridinoline cross-links due to higher telopeptide lysyl hydroxylase levels is a general fibrotic phenomenon. Matrix Biol. 23, 251–257 (2004).
Ge, H., Tian, M., Pei, Q., Tan, F. & Pei, H. Extracellular matrix stiffness: new areas affecting cell metabolism. Front. Oncol. 11, 631991 (2021).
Article CAS PubMed PubMed Central Google Scholar
Papandreou, I., Cairns, R. A., Fontana, L., Lim, A. L. & Denko, N. C. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab. 3, 187–197 (2006).
留言 (0)