Frailty Index, Not Age, Predicts Treatment Outcomes and Adverse Events for Older Adults with Cancer

Australian Institute of Health and Welfare. Cancer data in Australia. Canberra: AIHW; 2021.

Google Scholar 

Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381(9868):752–62. https://doi.org/10.1016/s0140-6736(12)62167-9

Article  PubMed  Google Scholar 

Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, et al. A global clinical measure of fitness and frailty in elderly people. Cmaj. 2005;173(5):489–95. https://doi.org/10.1503/cmaj.050051

Article  PubMed  PubMed Central  Google Scholar 

Burn R, Hubbard RE, Scrase RJ, Abey-Nesbit RK, Peel NM, Schluter PJ, et al. A frailty index derived from a standardized comprehensive geriatric assessment predicts mortality and aged residential care admission. BMC Geriatr. 2018;18(1):319. https://doi.org/10.1186/s12877-018-1016-8

Article  PubMed  PubMed Central  Google Scholar 

Handforth C, Clegg A, Young C, Simpkins S, Seymour MT, Selby PJ, et al. The prevalence and outcomes of frailty in older cancer patients: a systematic review. Ann Oncol. 2015;26(6):1091–101. https://doi.org/10.1093/annonc/mdu540

Article  CAS  PubMed  Google Scholar 

Hernandez Torres C, Hsu T. Comprehensive Geriatric Assessment in the Older Adult with Cancer: A Review. Eur Urol Focus. 2017;3(4–5):330–9. https://doi.org/10.1016/j.euf.2017.10.010

Article  PubMed  Google Scholar 

Mohile SG, Dale W, Somerfield MR, Schonberg MA, Boyd CM, Burhenn PS, et al. Practical Assessment and Management of Vulnerabilities in Older Patients Receiving Chemotherapy: ASCO Guideline for Geriatric Oncology. Journal of Clinical Oncology. 2018;36(22):2326–47. https://doi.org/10.1200/jco.2018.78.8687

Article  PubMed  PubMed Central  Google Scholar 

Puts MT, Tapscott B, Fitch M, Howell D, Monette J, Wan-Chow-Wah D, et al. A systematic review of factors influencing older adults’ decision to accept or decline cancer treatment. Cancer Treat Rev. 2015;41(2):197–215. https://doi.org/10.1016/j.ctrv.2014.12.010

Article  PubMed  Google Scholar 

Mohile SG, Epstein RM, Hurria A, Heckler CE, Canin B, Culakova E, et al. Communication With Older Patients With Cancer Using Geriatric Assessment: A Cluster-Randomized Clinical Trial From the National Cancer Institute Community Oncology Research Program. JAMA Oncol. 2020;6(2):196–204. https://doi.org/10.1001/jamaoncol.2019.4728

Article  PubMed  Google Scholar 

Wildiers H, Heeren P, Puts M, Topinkova E, Janssen-Heijnen ML, Extermann M, et al. International Society of Geriatric Oncology consensus on geriatric assessment in older patients with cancer. J Clin Oncol. 2014;32(24):2595–603. https://doi.org/10.1200/jco.2013.54.8347

Article  PubMed  PubMed Central  Google Scholar 

Dale W, Klepin HD, Williams GR, Alibhai SMH, Bergerot C, Brintzenhofeszoc K, et al. Practical Assessment and Management of Vulnerabilities in Older Patients Receiving Systemic Cancer Therapy: ASCO Guideline Update. Journal of Clinical Oncology. 2023. https://doi.org/10.1200/jco.23.00933

Searle SD, Mitnitski A, Gahbauer EA, Gill TM, Rockwood K. A standard procedure for creating a frailty index. BMC Geriatr. 2008;8:24. https://doi.org/10.1186/1471-2318-8-24

Article  PubMed  PubMed Central  Google Scholar 

Rockwood K, Mitnitski A. Frailty in relation to the accumulation of deficits. J Gerontol A Biol Sci Med Sci. 2007;62(7):722–7. https://doi.org/10.1093/gerona/62.7.722

Article  PubMed  Google Scholar 

McCarthy AL, Peel NM, Gillespie KM, Berry R, Walpole E, Yates P, et al. Validation of a frailty index in older cancer patients with solid tumours. BMC Cancer. 2018;18(1):892. https://doi.org/10.1186/s12885-018-4807-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Reiser E, Pötsch N, Seebacher V, Reinthaller A, Wimazal F, Fleischmann E, et al. Impact of frailty on the management of patients with gynecological cancer aged 80 years and older. Arch Gynecol Obstet. 2021;303(2):557–63. https://doi.org/10.1007/s00404-020-05807-9

Article  PubMed  Google Scholar 

Cohen HJ, Smith D, Sun CL, Tew W, Mohile SG, Owusu C, et al. Frailty as determined by a comprehensive geriatric assessment-derived deficit-accumulation index in older patients with cancer who receive chemotherapy. Cancer. 2016;122(24):3865–72. https://doi.org/10.1002/cncr.30269

Article  PubMed  Google Scholar 

Guerard EJ, Deal AM, Chang Y, Williams GR, Nyrop KA, Pergolotti M, et al. Frailty Index Developed From a Cancer-Specific Geriatric Assessment and the Association With Mortality Among Older Adults With Cancer. J Natl Compr Canc Netw. 2017;15(7):894–902. https://doi.org/10.6004/jnccn.2017.0122

Article  PubMed  Google Scholar 

Hembree T, Theou O, Thirlwell S, Reich RR, Cao B, Sehovic M, et al. A simple test-based frailty index to predict survival among cancer patients with an unplanned hospitalization: An observational cohort study. Cancer Medicine. 2021;10(17):5765–74. https://doi.org/10.1002/cam4.4107

Article  PubMed  PubMed Central  Google Scholar 

Jin X, Ren Y, Shao L, Guo Z, Wang C, He Y, et al. Prevalence of frailty and prediction of mortality in Chinese cancer patients using a frailty index-based clinical algorithm—A multicentre study. Cancer Medicine. 2021;10(18):6207–17. https://doi.org/10.1002/cam4.4155

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gomes F, Tay R, Chiramel J, Califano R. The Role of Targeted Agents and Immunotherapy in Older Patients with Non-small Cell Lung Cancer. Drugs & Aging. 2018;35(9):819–34. https://doi.org/10.1007/s40266-018-0573-z

Article  CAS  Google Scholar 

Fletcher JA, Logan B, Reid N, Gordon EH, Ladwa R, Hubbard RE. How frail is frail in oncology studies? A scoping review. BMC Cancer. 2023;23(1). https://doi.org/10.1186/s12885-023-10933-z

Google Scholar 

Rockwood K, Andrew M, Mitnitski A. A Comparison of Two Appoaches to Measuring Frailty in Elderly People. Journal of Gerontology. 2007;62A:738–43. https://doi.org/10.1093/gerona/62.7.738

Google Scholar 

Rockwood K, Mitnitski A. Limits to deficit accumulation in elderly people. Mech Ageing Dev. 2006;127(5):494–6. https://doi.org/10.1016/j.mad.2006.01.002

Article  PubMed  Google Scholar 

Bruijnen CP, Van Harten-Krouwel DG, Koldenhof JJ, Emmelot-Vonk MH, Witteveen PO. Predictive value of each geriatric assessment domain for older patients with cancer: A systematic review. Journal of Geriatric Oncology. 2019;10(6):859–73. https://doi.org/10.1016/j.jgo.2019.02.010

Article  PubMed  Google Scholar 

Schulkes KJ, Souwer ET, Hamaker ME, Codrington H, van der Sar-van der Brugge S, Lammers JJ, et al. The Effect of A Geriatric Assessment on Treatment Decisions for Patients with Lung Cancer. Lung. 2017;195(2):225–31. https://doi.org/10.1007/s00408-017-9983-7

Article  PubMed  PubMed Central  Google Scholar 

Wang Y, Zhang R, Shen Y, Su L, Dong B, Hao Q. Prediction of chemotherapy adverse reactions and mortality in older patients with primary lung cancer through frailty index based on routine laboratory data. Clin Interv Aging. 2019;Volume 14:1187–97. https://doi.org/10.2147/cia.s201873

Article  CAS  PubMed  PubMed Central  Google Scholar 

Narasimhulu DM, McGree ME, Weaver AL, Jatoi A, LeBrasseur NK, Glaser GE, et al. Frailty is a determinant of suboptimal chemotherapy in women with advanced ovarian cancer. Gynecologic Oncology. 2020;158(3):646–52. https://doi.org/10.1016/j.ygyno.2020.05.046

Article  CAS  PubMed  Google Scholar 

Ruiz J, Miller AA, Tooze JA, Crane S, Petty WJ, Gajra A, et al. Frailty assessment predicts toxicity during first cycle chemotherapy for advanced lung cancer regardless of chronologic age. J Geriatr Oncol. 2019;10(1):48–54. https://doi.org/10.1016/j.jgo.2018.06.007

Article  PubMed  Google Scholar 

van Walree IC, Scheepers E, van Huis-Tanja L, Emmelot-Vonk MH, Bellera C, Soubeyran P, et al. A systematic review on the association of the G8 with geriatric assessment, prognosis and course of treatment in older patients with cancer. J Geriatr Oncol. 2019;10(6):847–58. https://doi.org/10.1016/j.jgo.2019.04.016

Article  PubMed  Google Scholar 

Hamaker M, Lund C, Te Molder M, Soubeyran P, Wildiers H, Van Huis L, et al. Geriatric assessment in the management of older patients with cancer - A systematic review (update). Journal of Geriatric Oncology. 2022. https://doi.org/10.1016/j.jgo.2022.04.008

Kalsi T, Babic-Illman G, Fields P, Hughes S, Maisey N, Ross P, et al. The impact of low-grade toxicity in older people with cancer undergoing chemotherapy. British Journal of Cancer. 2014;111(12):2224–8. https://doi.org/10.1038/bjc.2014.496

Article  CAS  PubMed  PubMed Central  Google Scholar 

To THM, Soo WK, Lane H, Khattak A, Steer C, Devitt B, et al. Utilisation of geriatric assessment in oncology - a survey of Australian medical oncologists. Journal of Geriatric Oncology. 2019;10(2):216–21. https://doi.org/10.1016/j.jgo.2018.07.004

Article  PubMed  Google Scholar 

Kirkhus L, Šaltytė Benth J, Rostoft S, Grønberg BH, Hjermstad MJ, Selbæk G, et al. Geriatric assessment is superior to oncologists’ clinical judgement in identifying frailty. British Journal of Cancer. 2017;117(4):470–7. https://doi.org/10.1038/bjc.2017.202

Article  CAS  PubMed  PubMed Central  Google Scholar 

Antonio M, Saldaña J, Linares J, Ruffinelli JC, Palmero R, Navarro A, et al. Geriatric assessment may help decision-making in elderly patients with inoperable, locally advanced non-small-cell lung cancer. British Journal of Cancer. 2018;118(5):639–47. https://doi.org/10.1038/bjc.2017.455

Article  PubMed  PubMed Central  Google Scholar 

Rostoft S, O’Donovan A, Soubeyran P, Alibhai SMH, Hamaker ME. Geriatric Assessment and Management in Cancer. Journal of Clinical Oncology. 2021;39(19):2058–67. https://doi.org/10.1200/jco.21.00089

Article  PubMed  Google Scholar 

Li D, Sun C-L, Kim H, Soto-Perez-de-Celis E, Chung V, Koczywas M, et al. Geriatric Assessment-Driven Intervention (GAIN) on Chemotherapy-Related Toxic Effects in Older Adults With Cancer: A Randomized Clinical Trial. JAMA Oncology. 2021. https://doi.org/10.1001/jamaoncol.2021.4158

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