Cheong JK, Virshup DM. Casein kinase 1: Complexity in the family. Int J Biochem Cell Biol. 2011;43:465–9. https://doi.org/10.1016/j.biocel.2010.12.004.

Article  CAS  PubMed  Google Scholar 

Xu RM, Carmel G, Sweet RM, Kuret J, Cheng X. Crystal structure of casein kinase-1, a phosphate-directed protein kinase. EMBO J. 1995;14:1015–23. https://doi.org/10.1002/j.1460-2075.1995.tb07082.x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Du C, Yang H, Feng F, Liu W, Chen Y, Sun H. Achieving effective and selective CK1 inhibitors through structure modification. Future Med Chem. 2021;13:505–28. https://doi.org/10.4155/fmc-2020-0215.

Article  CAS  PubMed  Google Scholar 

Gross SD, Anderson RA. Casein kinase I: spatial organization and positioning of a multifunctional protein kinase family. Cell Signal. 1998;10:699–711. https://doi.org/10.1016/s0898-6568(98)00042-4.

Article  CAS  PubMed  Google Scholar 

Rowles J, Slaughter C, Moomaw C, Hsu J, Cobb MH. Purification of casein kinase I and isolation of cDNAs encoding multiple casein kinase I-like enzymes. Proc Natl Acad Sci USA. 1991;88:9548–52. https://doi.org/10.1073/pnas.88.21.9548.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Knippschild U, Gocht A, Wolff S, Huber N, Lohler J, Stoter M. The casein kinase 1 family: participation in multiple cellular processes in eukaryotes. Cell Signal. 2005;17:675–89. https://doi.org/10.1016/j.cellsig.2004.12.011.

Article  CAS  PubMed  Google Scholar 

Etchegaray JP, Machida KK, Noton E, Constance CM, Dallmann R, Di Napoli MN, et al. Casein kinase 1 delta regulates the pace of the mammalian circadian clock. Mol Cell Biol. 2009;29:3853–66. https://doi.org/10.1128/MCB.00338-09.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kalousi A, Mylonis I, Politou AS, Chachami G, Paraskeva E, Simos G. Casein kinase 1 regulates human hypoxia-inducible factor HIF-1. J Cell Sci. 2010;123:2976–86. https://doi.org/10.1242/jcs.068122.

Article  CAS  PubMed  Google Scholar 

Greer YE, Gao B, Yang Y, Nussenzweig A, Rubin JS. Lack of Casein Kinase 1 Delta Promotes Genomic Instability - The Accumulation of DNA Damage and Down-Regulation of Checkpoint Kinase 1. PLoS One. 2017;12:e0170903 https://doi.org/10.1371/journal.pone.0170903.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Graves PR, Haas DW, Hagedorn CH, DePaoli-Roach AA, Roach PJ. Molecular cloning, expression, and characterization of a 49-kilodalton casein kinase I isoform from rat testis. J Biol Chem. 1993;268:6394–401.

Article  CAS  PubMed  Google Scholar 

Lohler J, Hirner H, Schmidt B, Kramer K, Fischer D, Thal DR, et al. Immunohistochemical characterisation of cell-type specific expression of CK1delta in various tissues of young adult BALB/c mice. PLoS One. 2009;4:e4174 https://doi.org/10.1371/journal.pone.0004174.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Behrend L, Stoter M, Kurth M, Rutter G, Heukeshoven J, Deppert W, et al. Interaction of casein kinase 1 delta (CK1delta) with post-Golgi structures, microtubules and the spindle apparatus. Eur J Cell Biol. 2000;79:240–51. https://doi.org/10.1078/s0171-9335(04)70027-8.

Article  CAS  PubMed  Google Scholar 

von Blume J, Knippschild U, Dequiedt F, Giamas G, Beck A, Auer A, et al. Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2. EMBO J. 2007;26:4619–33. https://doi.org/10.1038/sj.emboj.7601891.

Article  CAS  Google Scholar 

Xu P, Ianes C, Gartner F, Liu C, Burster T, Bakulev V, et al. Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D). Gene. 2019;715:144005 https://doi.org/10.1016/j.gene.2019.144005.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Knippschild U, Wolff S, Giamas G, Brockschmidt C, Wittau M, Wurl PU, et al. The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development. Onkologie. 2005;28:508–14. https://doi.org/10.1159/000087137.

Article  CAS  PubMed  Google Scholar 

Richter J, Rudeck S, Kretz AL, Kramer K, Just S, Henne-Bruns D, et al. Decreased CK1delta expression predicts prolonged survival in colorectal cancer patients. Tumour Biol. 2016;37:8731–9. https://doi.org/10.1007/s13277-015-4745-8.

Article  CAS  PubMed  Google Scholar 

Alquezar C, Salado IG, de la Encarnacion A, Perez DI, Moreno F, Gil C, et al. Targeting TDP-43 phosphorylation by Casein Kinase-1delta inhibitors: a novel strategy for the treatment of frontotemporal dementia. Mol Neurodegener. 2016;11:36 https://doi.org/10.1186/s13024-016-0102-7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Catarzi D, Varano F, Vigiani E, Lambertucci C, Spinaci A, Volpini R, et al. Casein Kinase 1delta Inhibitors as Promising Therapeutic Agents for Neurodegenerative Disorders. Curr Med Chem. 2022;29:4698–737. https://doi.org/10.2174/0929867329666220301115124.

Article  CAS  PubMed  Google Scholar 

Spinaci A, Buccioni M, Catarzi D, Cui C, Colotta V, Dal Ben D, et al. “Dual Anta-Inhibitors” of the A2A Adenosine Receptor and Casein Kinase CK1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies. Pharmaceuticals. 2023;16:167. https://doi.org/10.3390/ph16020167.

Li SS, Dong YH, Liu ZP. Recent Advances in the Development of Casein Kinase 1 Inhibitors. Curr Med Chem. 2021;28:1585–604. https://doi.org/10.2174/0929867327666200713185413.

Article  CAS  PubMed  Google Scholar 

Oumata N, Bettayeb K, Ferandin Y, Demange L, Lopez-Giral A, Goddard ML, et al. Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1. J Med Chem. 2008;51:5229–42. https://doi.org/10.1021/jm800109e.

Article  CAS  PubMed  Google Scholar 

Bibian M, Rahaim RJ, Choi JY, Noguchi Y, Schurer S, Chen W, et al. Development of highly selective casein kinase 1delta/1epsilon (CK1delta/epsilon) inhibitors with potent antiproliferative properties. Bioorg Med Chem Lett. 2013;23:4374–80. https://doi.org/10.1016/j.bmcl.2013.05.075.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Thomas A, Buccioni M, Dal Ben D, Lambertucci C, Marucci G, Santinelli C, et al. The Length and Flexibility of the 2-Substituent of 9-Ethyladenine Derivatives Modulate Affinity and Selectivity for the Human A2A Adenosine Receptor. ChemMedChem. 2016;11:1829–39. https://doi.org/10.1002/cmdc.201500595.

Article  CAS  PubMed  Google Scholar 

Rosenberg LH, Lafitte M, Quereda V, Grant W, Chen W, Bibian M, et al. Therapeutic targeting of casein kinase 1delta in breast cancer. Sci Transl Med. 2015;7:318ra202 https://doi.org/10.1126/scitranslmed.aac8773.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Halekotte J, Witt L, Ianes C, Kruger M, Buhrmann M, Rauh D, et al. Optimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1delta and Their Structural Relation to p38alpha MAPK. Molecules. 2017;22. https://doi.org/10.3390/molecules22040522.

Camaioni E, Costanzi S, Vittori S, Volpini R, Klotz K-N, Cristalli G. New substituted 9-alkylpurines as adenosine receptor ligands. Bioorg Med Chem. 1998;6:523–33. https://doi.org/10.1016/S0968-0896(98)00007-8.

Article  CAS  PubMed  Google Scholar 

Lin X, Robins MJ. Nucleic Acid Related Compounds. 136. Synthesis of 2-Amino- and 2,6-Diaminopurine Derivatives via Inverse-Electron-Demand Diels-Alder Reactions. Collect Czech Chem Commun. 2006;71:1029–41. https://doi.org/10.1135/cccc20061029.

Article  CAS  Google Scholar 

Lambertucci C, Antonini I, Buccioni M, Dal Ben D, Kachare DD, Volpini R, et al. 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009;17:2812–22. https://doi.org/10.1016/j.bmc.2009.02.030.

Article  CAS  PubMed  Google Scholar 

Salado IG, Redondo M, Bello ML, Perez C, Liachko NF, Kraemer BC, et al. Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis. J Med Chem. 2014;57:2755–72. https://doi.org/10.1021/jm500065f.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Badura L, Swanson T, Adamowicz W, Adams J, Cianfrogna J, Fisher K, et al. An inhibitor of casein kinase I epsilon induces phase delays in circadian rhythms under free-running and entrained conditions. J Pharmacol Exp Ther. 2007;322:730–8. https://doi.org/10.1124/jpet.107.122846.

Article  CAS  PubMed  Google Scholar 

Molecular Operating Environment (MOE); Chemical Computing Group ULC, 910-1010 Sherbrooke St. W., Montreal, QC H3A 2R7, Canada. https://www.chemcomp.com/Research-Citing_MOE.htm.