Livingstone SA, Wildi KS, Dalton HJ, Usman A, Ki KK, Passmore MR, et al. Coagulation dysfunction in acute respiratory distress syndrome and its potential impact in inflammatory subphenotypes. Front Med. 2021. https://doi.org/10.3389/fmed.2021.723217.
Meyer NJ, Gattinoni L, Calfee CS. Acute respiratory distress syndrome. Lancet Lond Engl. 2021;398(10300):622–37.
Félétou M, Vanhoutte PM. Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture). Am J Physiol Heart Circ Physiol. 2006;291(3):H985-1002.
Günther A, Mosavi P, Heinemann S, Ruppert C, Muth H, Markart P, et al. Alveolar fibrin formation caused by enhanced procoagulant and depressed fibrinolytic capacities in severe pneumonia. Am J Respir Crit Care Med. 2000;161(2):454–62.
van Haren FMP, Laffey JG, Artigas A, Page C, Schultz MJ, Cosgrave D, et al. Can nebulised HepArin Reduce morTality and time to Extubation in patients with COVID-19 Requiring invasive ventilation Meta-Trial (CHARTER-MT): protocol and statistical analysis plan for an investigator-initiated international meta-trial of prospective randomised clinical studies. Br J Clin Pharmacol. 2022;88(7):3272–87.
Buijsers B, Yanginlar C, Maciej-Hulme ML, de Mast Q, van der Vlag J. Beneficial non-anticoagulant mechanisms underlying heparin treatment of COVID-19 patients. EBioMedicine. 2020;25(59): 102969.
Mycroft-West CJ, Su D, Pagani I, Rudd TR, Elli S, Gandhi NS, et al. Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the spike S1 receptor-binding domain with heparin. Thromb Haemost. 2020;120(12):1700–15.
Article PubMed PubMed Central Google Scholar
Wang L, Brown JR, Varki A, Esko JD. Heparin’s anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins. J Clin Invest. 2002;110(1):127–36.
Article CAS PubMed PubMed Central Google Scholar
Ahmed T, Garrigo J, Danta I. Preventing bronchoconstriction in exercise-induced asthma with inhaled heparin. N Engl J Med. 1993;329(2):90–5.
Article CAS PubMed Google Scholar
Rao NV, Argyle B, Xu X, Reynolds PR, Walenga JM, Prechel M, et al. Low anticoagulant heparin targets multiple sites of inflammation, suppresses heparin-induced thrombocytopenia, and inhibits interaction of RAGE with its ligands. Am J Physiol Cell Physiol. 2010;299(1):C97-110.
Article CAS PubMed Google Scholar
Spencer JL, Stone PJ, Nugent MA. New insights into the inhibition of human neutrophil elastase by heparin. Biochemistry. 2006;45(30):9104–20.
Article CAS PubMed Google Scholar
Porto BN, Stein RT. Neutrophil extracellular traps in pulmonary diseases: too much of a good thing? Front Immunol. 2016;15(7):311.
Broughton-Head VJ, Shur J, Carroll MP, Smith JR, Shute JK. Unfractionated heparin reduces the elasticity of sputum from patients with cystic fibrosis. Am J Physiol Lung Cell Mol Physiol. 2007;293(5):L1240-1249.
Article CAS PubMed Google Scholar
Dixon B, Smith RJ, Campbell DJ, Moran JL, Doig GS, Rechnitzer T, et al. Nebulised heparin for patients with or at risk of acute respiratory distress syndrome: a multicentre, randomised, double-blind, placebo-controlled phase 3 trial. Lancet Respir Med. 2021;9(4):360–72.
Article CAS PubMed PubMed Central Google Scholar
van Haren FMP, Page C, Laffey JG, Artigas A, Camprubi-Rimblas M, Nunes Q, et al. Nebulised heparin as a treatment for COVID-19: scientific rationale and a call for randomised evidence. Crit Care. 2020;24(1):454.
Article PubMed PubMed Central Google Scholar
Xiong J, Ai Q, Bao L, Shi Y. Protective effect of unfractionated heparin on lipopolysaccharide-induced acute respiratory distress syndrome in neonatal mice via the JAK2/STAT3 signaling pathway. Front Biosci-Landmark. 2023;28(6):108.
Johnson AEW, Bulgarelli L, Shen L, Gayles A, Shammout A, Horng S, et al. MIMIC-IV, a freely accessible electronic health record dataset. Sci Data. 2023;10(1):1.
Article CAS PubMed PubMed Central Google Scholar
ARDS Definition Task Force, Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, et al. Acute respiratory distress syndrome: the Berlin Definition. JAMA. 2012;307(23):2526–33.
Zhang Z, Kim HJ, Lonjon G, Zhu Y. Balance diagnostics after propensity score matching. Ann Transl Med. 2019;7(1):16.
Article CAS PubMed PubMed Central Google Scholar
Kurz CF. Augmented inverse probability weighting and the double robustness property. Med Decis Making. 2022;42(2):156–67.
VanderWeele TJ, Ding P. Sensitivity analysis in observational research: introducing the E-value. Ann Intern Med. 2017;167(4):268–74.
Haneuse S, VanderWeele TJ, Arterburn D. Using the E-value to assess the potential effect of unmeasured confounding in observational studies. JAMA. 2019;321(6):602–3.
Grasselli G, Calfee CS, Camporota L, Poole D, Amato MBP, Antonelli M, et al. ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies. Intensive Care Med. 2023;49(7):727–59.
Article PubMed PubMed Central Google Scholar
Camprubí-Rimblas M, Tantinyà N, Bringué J, Guillamat-Prats R, Artigas A. Anticoagulant therapy in acute respiratory distress syndrome. Ann Transl Med. 2018;6(2):36–36.
Article PubMed PubMed Central Google Scholar
Shute JK. Heparin, low molecular weight heparin, and non-anticoagulant derivatives for the treatment of inflammatory lung disease. Pharmaceuticals. 2023;16(4):584.
Article CAS PubMed PubMed Central Google Scholar
Wang C, Chi C, Guo L, Wang X, Guo L, Sun J, et al. Heparin therapy reduces 28-day mortality in adult severe sepsis patients: a systematic review and meta-analysis. Crit Care. 2014;18(5):563.
Article PubMed PubMed Central Google Scholar
Therapeutic anticoagulation with heparin in noncritically Ill patients with Covid-19. N Engl J Med. 2021; 385: 790.
Hofstra JJ, Vlaar APJ, Prins DJ, Koh G, Levi M, Schultz MJ, et al. Early intravenous unfractionated heparin and outcome in acute lung injury and acute respiratory distress syndrome—a retrospective propensity matched cohort study. BMC Pulm Med. 2012;15(12):43.
Zarychanski R, Doucette S, Fergusson D, Roberts D, Houston DS, Sharma S, et al. Early intravenous unfractionated heparin and mortality in septic shock. Crit Care Med. 2008;36(11):2973–9.
Article CAS PubMed Google Scholar
Paranjpe I, Fuster V, Lala A, Russak AJ, Glicksberg BS, Levin MA, et al. Association of treatment dose anticoagulation with in-hospital survival among hospitalized patients with COVID-19. J Am Coll Cardiol. 2020;76(1):122.
Article CAS PubMed PubMed Central Google Scholar
Rentsch CT, Beckman JA, Tomlinson L, Gellad WF, Alcorn C, Kidwai-Khan F, et al. Early initiation of prophylactic anticoagulation for prevention of coronavirus disease 2019 mortality in patients admitted to hospital in the United States: cohort study. The BMJ. 2021;11(372): n311.
Al-Samkari H, Gupta S, Leaf RK, Wang W, Rosovsky RP, Brenner SK, et al. Thrombosis, bleeding, and the observational effect of early therapeutic anticoagulation on survival in critically ill patients with COVID-19. Ann Intern Med. 2021;26:M20-6739.
Kim J, Baalachandran R, Li Y, Zhang CO, Ke Y, Karki P, et al. Circulating extracellular histones exacerbate acute lung injury by augmenting pulmonary endothelial dysfunction via TLR4-dependent mechanism. Am J Physiol Lung Cell Mol Physiol. 2022;323(3):L223–39.
Article CAS PubMed PubMed Central Google Scholar
Chimenti L, Camprubí-Rimblas M, Guillamat-Prats R, Gomez MN, Tijero J, Blanch L, et al. Nebulized heparin attenuates pulmonary coagulopathy and inflammation through alveolar macrophages in a rat model of acute lung injury. Thromb Haemost. 2017;117(11):2125–34.
Article PubMed PubMed Central Google Scholar
Juschten J, Tuinman PR, Juffermans NP, Dixon B, Levi M, Schultz MJ. Nebulized anticoagulants in lung injury in critically ill patients—an updated systematic review of preclinical and clinical studies. Ann Transl Med. 2017;5(22):444.
Article PubMed PubMed Central Google Scholar
Gupta B, Chandrakar S, Gupta N, Jain G. Nebulized heparin to reduce COVID-19-induced acute lung injury: a prospective observational study. Indian J Crit Care Med Peer-Rev Off Publ Indian Soc Crit Care Med. 2023;27(3):222–4.
Sheehan JR, Calpin P, Kernan M, Kelly C, Casey S, Murphy D, et al. The CHARTER-Ireland trial: can nebulised heparin reduce acute lung injury in patients with SARS-CoV-2 requiring advanced respiratory support in Ireland: a study protocol and statistical analysis plan for a randomised control trial. Trials. 2022;23(1):774.
Article CAS PubMed PubMed Central Google Scholar
Mulloy B, Hogwood J, Gray E, Lever R, Page CP. Pharmacology of heparin and related drugs. Pharmacol Rev. 2016;68(1):76–141.
Camprubí-Rimblas M, Guillamat-Prats R, Lebouvier T, Bringué J, Chimenti L, Iglesias M, et al. Role of heparin in pulmonary cell populations in an in-vitro model of acute lung injury. Respir Res. 2017;18:89.
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