Abnormal DNA methylation within HPA-axis genes years after paediatric critical illness

Jacobs A, Derese I, Vander Perre S, Wouters PJ, Verbruggen S, Billen J, et al. Dynamics and prognostic value of the hypothalamus–pituitary–adrenal axis responses to pediatric critical illness and association with corticosteroid treatment: a prospective observational study. Intensive Care Med. 2020;46:70–81.

Article  CAS  PubMed  Google Scholar 

Jacobs A, Derese I, Vander Perre S, van Puffelen E, Verstraete S, Pauwels L, et al. Non-thyroidal illness syndrome in critically ill children: prognostic value and impact of nutritional management. Thyroid. 2019;29:480–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gielen M, Mesotten D, Brugts M, Coopmans W, Van Herck E, Vanhorebeek I, et al. Effect of intensive insulin therapy on the somatotropic axis of critically ill children. J Clin Endocrinol Metab. 2011;96:2558–66.

Article  CAS  PubMed  Google Scholar 

Van Dyck L, Derese I, Vander Perre S, Wouters PJ, Casaer MP, Hermans G, et al. The GH axis in relation to accepting an early macronutrient deficit and outcome of critically ill patients. J Clin Endocrinol Metab. 2019;104:5507–18.

Article  PubMed  Google Scholar 

Gardelis JG, Hatzis TD, Stamogiannou LN, Dona AA, Fotinou AD, Brestas PS, Constantopoulos AG. Activity of the growth hormone/insulin-like growth factor-I axis in critically ill children. J Pediatr Endocrinol Metab. 2005;18:363–72.

Article  CAS  PubMed  Google Scholar 

Teblick A, Peeters B, Langouche L, Van den Berghe G. Adrenal function and dysfunction in critically ill patients. Nat Rev Endocrinol. 2019;15:417–27.

Article  CAS  PubMed  Google Scholar 

Langouche L, Téblick A, Gunst J, Van den Berghe G. The hypothalamus-pituitary-adrenocortical response to critical illness: a concept in need of revision. Endocr Rev. 2023;44:1096–106.

Article  PubMed  PubMed Central  Google Scholar 

Poomthavorn P, Lertbunrian R, Preutthipan A, Sriphrapradang A, Khlairit P, Mahachoklertwattana P. Serum free cortisol index, free cortisol, and total cortisol in critically ill children. Intensive Care Med. 2009;35:1281–5.

Article  CAS  PubMed  Google Scholar 

Aydin BK, Demirkol D, Bas F, Turkoglu U, Kumral A, Karabocuoglu M, et al. Evaluation of endocrine function in children admitted to pediatric intensive care unit. Pediatr Int. 2014;56:349–53.

Article  CAS  PubMed  Google Scholar 

Peeters B, Meersseman P, Vander Perre S, Wouters PJ, Vanmarcke D, Debaveye Y, et al. Adrenocortical function during prolonged critical illness and beyond: a prospective observational study. Intensive Care Med. 2018;44:1720–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boonen E, Vervenne H, Meersseman P, Andrew R, Mortier L, Declercq PE, et al. Reduced cortisol metabolism during critical illness. N Engl J Med. 2013;368:1477–88.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Verstraete S, Verbruggen SC, Hordijk JA, Vanhorebeek I, Dulfer K, Guiza F, et al. Long-term developmental effects of withholding parenteral nutrition for 1 week in the paediatric intensive care unit: a 2-year follow-up of the PEPaNIC international, randomised, controlled trial. Lancet Respir Med. 2019;7:141–53.

Article  PubMed  Google Scholar 

Jacobs A, Dulfer K, Eveleens RD, Hordijk J, Van Cleemput H, Verlinden I, et al. Long-term developmental effect of withholding parenteral nutrition in paediatric intensive care units: a 4-year follow-up of the PEPaNIC randomised controlled trial. Lancet Child Adolesc Health. 2020;4:503–14.

Article  PubMed  Google Scholar 

Watson RS, Choong K, Colville G, Crow S, Dervan LA, Hopkins RO, Knoester H, Pollack MM, Rennick J, Curley MAQ. Life after critical illness in children-toward an understanding of pediatric post-intensive care syndrome. J Pediatr. 2018;198:16–24.

Article  PubMed  Google Scholar 

Watson RS, Beers SR, Asaro LA, Burns C, Koh MJ, Perry MA, Angus DC, Wypij D, Curley MAQ, RESTORE-Cognition Investigators. Association of acute respiratory failure in early childhood with long-term neurocognitive outcomes. JAMA. 2022;327:836–45.

Article  PubMed  PubMed Central  Google Scholar 

Hordijk JA, Verbruggen SC, Buysse CM, Utens EM, Joosten KF, Dulfer K. Neurocognitive functioning and health-related quality of life of children after pediatric intensive care admission: a systematic review. Qual Life Res. 2022;31:2601–14.

Article  PubMed  PubMed Central  Google Scholar 

Perry-Eaddy M, Dervan LA, Manning JC, Watson RS, Curley MAQ. Pediatric critical care outcomes: state of the science. Crit Care Clin. 2023;39:309–26.

Article  PubMed  Google Scholar 

Facchi JC, Lima TAL, Oliveira LR, Costermani HO, Miranda GDS, de Oliveira JC. Perinatal programming of metabolic diseases: the role of glucocorticoids. Metabolism. 2020;104:154047.

Article  CAS  PubMed  Google Scholar 

Bale TL, Baram TZ, Brown AS, Goldstein JM, Insel TR, McCarthy MM, et al. Early life programming and neurodevelopmental disorders. Biol Psychiatry. 2010;68:314–9.

Article  PubMed  PubMed Central  Google Scholar 

van Bodegom M, Homberg JR, Henckens M. Modulation of the hypothalamic-pituitary-adrenal axis by early life stress exposure. Front Cell Neurosci. 2017;11:87.

PubMed  PubMed Central  Google Scholar 

Featherstone RE, Gifford RL, Crown LM, Amirfathi F, Alaniz JP, Yi J, et al. Early life social instability stress causes lasting cognitive decrement and elevated hippocampal stress-related gene expression. Exp Neurol. 2022;354:114099.

Article  CAS  PubMed  Google Scholar 

Fitzgerald E, Sinton MC, Wernig-Zorc S, Morton NM, Holmes MC, Boardman JP, et al. Altered hypothalamic DNA methylation and stress-induced hyperactivity following early life stress. Epigenetics Chromatin. 2021;14:31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yehuda R, Daskalakis NP, Bierer LM, Bader HN, Klengel T, Holsboer F, et al. Holocaust exposure induced intergenerational effects on FKBP5 methylation. Biol Psychiatry. 2016;80:372–80.

Article  CAS  PubMed  Google Scholar 

Glad CA, Andersson-Assarsson JC, Berglund P, Bergthorsdottir R, Ragnarsson O, Johannsson G. Reduced DNA methylation and psychopathology following endogenous hypercortisolism: a genome-wide study. Sci Rep. 2017;7:44445.

Article  CAS  PubMed  PubMed Central  ADS  Google Scholar 

Wiechmann T, Roh S, Sauer S, Czamara D, Arloth J, Kodel M, et al. Identification of dynamic glucocorticoid-induced methylation changes at the FKBP5 locus. Clin Epigenetics. 2019;11:83.

Article  PubMed  PubMed Central  Google Scholar 

Lewis CR, Breitenstein RS, Henderson A, Sowards HA, Piras IS, Huentelman MJ, et al. Harsh parenting predicts novel HPA receptor gene methylation and NR3C1 methylation predicts cortisol daily slope in middle childhood. Cell Mol Neurobiol. 2021;41:783–93.

Article  CAS  PubMed  Google Scholar 

Murgatroyd C, Patchev AV, Wu Y, Micale V, Bockmuhl Y, Fischer D, et al. Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat Neurosci. 2009;12:1559–66.

Article  CAS  PubMed  Google Scholar 

Wu Y, Patchev AV, Daniel G, Almeida OF, Spengler D. Early-life stress reduces DNA methylation of the Pomc gene in male mice. Endocrinology. 2014;155:1751–62.

Article  PubMed  Google Scholar 

Palma-Gudiel H, Prather AA, Lin J, Oxendine JD, Guintivano J, Xia K, et al. HPA axis regulation and epigenetic programming of immune-related genes in chronically stressed and non-stressed mid-life women. Brain Behav Immun. 2021;92:49–56.

Article  CAS  PubMed  Google Scholar 

Tyrka AR, Ridout KK, Parade SH. Childhood adversity and epigenetic regulation of glucocorticoid signaling genes: associations in children and adults. Dev Psychopathol. 2016;28:1319–31.

Article  PubMed  PubMed Central  Google Scholar 

Kertes DA, Kamin HS, Hughes DA, Rodney NC, Bhatt S, Mulligan CJ. Prenatal maternal stress predicts methylation of genes regulating the hypothalamic-pituitary-adrenocortical system in mothers and newborns in the democratic republic of Congo. Child Dev. 2016;87:61–72.

Article  PubMed  PubMed Central  Google Scholar 

Jensen Pena C, Monk C, Champagne FA. Epigenetic effects of prenatal stress on 11beta-hydroxysteroid dehydrogenase-2 in the placenta and fetal brain. PLoS ONE. 2012;7:e39791.

Article  PubMed  PubMed Central  ADS  Google Scholar 

Yehuda R, Seckl J. Minireview: Stress-related psychiatric disorders with low cortisol levels: a metabolic hypothesis. Endocrinology. 2011;152:4496–503.

Article  CAS  PubMed  Google Scholar 

Green BB, Armstrong DA, Lesseur C, Paquette AG, Guerin DJ, Kwan LE, Marsit CJ. The role of placental 11-beta hydroxysteroid dehydrogenase type 1 and type 2 methylation on gene expression and infant birth weight. Biol Reprod. 2015;92:149.

Article  PubMed  PubMed Central  Google Scholar 

Nagarajan S, Seddighzadeh B, Baccarelli A, Wise LA, Williams M, Shields AE. Adverse maternal exposures, methylation of glucocorticoid-related genes and perinatal outcomes: a systematic review. Epigenomics. 2016;8:925–44.

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