Serotonin stimulation of corticosteroid secretion is mediated by 5-HT receptors, requires cAMP production, PKA activation, and calcium influx through T-type (CaV3) voltage-gated calcium channels, with some possible involvement of L-type (CaV1) voltage-gated calcium channels (Contesse et al., 1996, Lenglet et al., 2002, Louiset et al., 2017, Rossier, 2016, Yang et al., 2020).

In frogs and humans, 5-HT binds to 5-HT4 receptors (Contesse et al., 1996, Contesse et al., 1994, Idres et al., 1991,