The role of pregnancy associated plasma protein-A in triple negative breast cancer: a promising target for achieving clinical benefits

Lin TM, Galbert SP, Kiefer D, Spellacy WN, Gall S. Characterization of four human pregnancy-associated plasma proteins. Am J Obstet Gynecol. 1974;118(2):223–36.

Article  CAS  PubMed  Google Scholar 

Lawrence JB, Oxvig C, Overgaard MT, Sottrup-Jensen L, Gleich GJ, Hays LG, et al. The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A. Proc Natl Acad Sci U S A. 1999;96(6):3149–53.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Qin QP, Christiansen M, Oxvig C, Pettersson K, Sottrup-Jensen L, Koch C, et al. Double-monoclonal immunofluorometric assays for pregnancy-associated plasma protein A/proeosinophil major basic protein (PAPP-A/proMBP) complex in first-trimester maternal serum screening for Down syndrome. Clin Chem. 1997;43(12):2323–32.

Article  CAS  PubMed  Google Scholar 

Bonno M, Oxvig C, Kephart GM, Wagner JM, Kristensen T, Sottrup-Jensen L, et al. Localization of pregnancy-associated plasma protein-A and colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta. Lab Invest. 1994;71(4):560–6.

CAS  PubMed  Google Scholar 

Overgaard MT, Oxvig C, Christiansen M, Lawrence JB, Conover CA, Gleich GJ, et al. Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein: expression in human reproductive and nonreproductive tissues. Biol Reprod. 1999;61(4):1083–9.

Article  CAS  PubMed  Google Scholar 

Guo Y, Bao Y, Guo D, Yang W. Pregnancy-associated plasma protein a in cancer: expression, oncogenic functions and regulation. Am J Cancer Res. 2018;8(6):955–63.

CAS  PubMed  PubMed Central  Google Scholar 

Jenkins EC, Brown SO, Germain D. The multi-faced role of PAPP-A in post-partum breast cancer: IGF-signaling is only the beginning. J Mammary Gland Biol Neoplasia. 2020;25(3):181–9.

Article  PubMed  Google Scholar 

Heitzeneder S, Sotillo E, Shern JF, Sindiri S, Xu P, Jones R, et al. Pregnancy-associated plasma protein-a (Papp-A) in ewing sarcoma: role in tumor growth and immune evasion. J Natl Cancer Inst. 2019;111(9):970–82.

Article  PubMed  PubMed Central  Google Scholar 

D’Elia P, Ionta V, Chimenti I, Angelini F, Miraldi F, Pala A, et al. Analysis of pregnancy-associated plasma protein A production in human adult cardiac progenitor cells. Biomed Res Int. 2013;2013: 190178.

PubMed  PubMed Central  Google Scholar 

Hjortebjerg R. IGFBP-4 and PAPP-A in normal physiology and disease. Growth Horm IGF Res. 2018;41:7–22.

Article  CAS  PubMed  Google Scholar 

Conover CA, Bale LK. Loss of pregnancy-associated plasma protein A extends lifespan in mice. Aging Cell. 2007;6(5):727–9.

Article  CAS  PubMed  Google Scholar 

Oxvig C. The role of PAPP-A in the IGF system: location, location, location. J Cell Commun Signal. 2015;9(2):177–87.

Article  PubMed  PubMed Central  Google Scholar 

Bowers LW, Rossi EL, O’Flanagan CH, deGraffenried LA, Hursting SD. The role of the Insulin/IGF system in cancer: lessons learned from clinical trials and the energy balance-cancer link. Front Endocrinol (Lausanne). 2015;6:77.

Article  PubMed  Google Scholar 

Conover CA, Oxvig C. PAPP-A and cancer. J Mol Endocrinol. 2018;61(1):T1-t10.

Article  CAS  PubMed  Google Scholar 

Conover CA, Oxvig C. The pregnancy-associated plasma protein-A (PAPP-A) story. Endocr Rev. 2023;44(6):1012–28.

Article  PubMed  Google Scholar 

Prithviraj P, Anaka M, Thompson EW, Sharma R, Walkiewicz M, Tutuka CSA, et al. Aberrant pregnancy-associated plasma protein-A expression in breast cancers prognosticates clinical outcomes. Sci Rep. 2020;10(1):13779.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang J, Zhang Y, Li L, Nian Y, Chen Y, Shen R, et al. Pregnancy-associated plasma protein-A (PAPPA) promotes breast cancer progression. Bioengineered. 2022;13(1):291–307.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Smith YE, Toomey S, Napoletano S, Kirwan G, Schadow C, Chubb AJ, et al. Recombinant PAPP-A resistant insulin-like growth factor binding protein 4 (dBP4) inhibits angiogenesis and metastasis in a murine model of breast cancer. BMC Cancer. 2018;18(1):1016.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Becker MA, Haluska P Jr, Bale LK, Oxvig C, Conover CA. A novel neutralizing antibody targeting pregnancy-associated plasma protein-a inhibits ovarian cancer growth and ascites accumulation in patient mouse tumorgrafts. Mol Cancer Ther. 2015;14(4):973–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang J, Tabata S, Kakiuchi S, Van The T, Goto H, Hanibuchi M, et al. Identification of pregnancy-associated plasma protein A as a migration-promoting gene in malignant pleural mesothelioma cells: a potential therapeutic target. Oncotarget. 2013;4(8):1172–84.

Article  PubMed  PubMed Central  Google Scholar 

Engelmann JC, Amann T, Ott-Rötzer B, Nützel M, Reinders Y, Reinders J, et al. Causal modeling of cancer-stromal communication identifies PAPPA as a Novel Stroma-Secreted factor activating NFκB signaling in hepatocellular carcinoma. PLoS Comput Biol. 2015;11(5): e1004293.

Article  PubMed  PubMed Central  Google Scholar 

Itoh G, Takagane K, Fukushi Y, Kuriyama S, Umakoshi M, Goto A, et al. Cancer-associated fibroblasts educate normal fibroblasts to facilitate cancer cell spreading and T-cell suppression. Mol Oncol. 2022;16(1):166–87.

Article  CAS  PubMed  Google Scholar 

Kuhajda FP, Eggleston JC. Pregnancy-associated plasma protein A. A clinically significant predictor of early recurrence in stage I breast carcinoma is independent of estrogen receptor status. Am J Pathol. 1985;121(2):342–8.

CAS  PubMed  PubMed Central  Google Scholar 

Mansfield AS, Visscher DW, Hart SN, Wang C, Goetz MP, Oxvig C, et al. Pregnancy-associated plasma protein-A expression in human breast cancer. Growth Horm IGF Res. 2014;24(6):264–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gadaleta E, Thorn GJ, Ross-Adams H, Jones LJ, Chelala C. Field cancerization in breast cancer. J Pathol. 2022;257(4):561–74.

Article  PubMed  PubMed Central  Google Scholar 

Azamjah N, Soltan-Zadeh Y, Zayeri F. Global trend of breast cancer mortality rate: a 25-year study. Asian Pac J Cancer Prev. 2019;20(7):2015–20.

Article  PubMed  PubMed Central  Google Scholar 

Poddar A, Rao SR, Prithviraj P, Kannourakis G, Jayachandran A. Crosstalk between immune checkpoint modulators, metabolic reprogramming and cellular plasticity in triple-negative breast cancer. Curr Oncol. 2022;29(10):6847–63.

Article  PubMed  PubMed Central  Google Scholar 

Emens LA, Cruz C, Eder JP, Braiteh F, Chung C, Tolaney SM, et al. Long-term clinical outcomes and biomarker analyses of atezolizumab therapy for patients with metastatic triple-negative breast cancer: a phase 1 study. JAMA Oncol. 2019;5(1):74–82.

Article  PubMed  Google Scholar 

Ensenyat-Mendez M, Llinas-Arias P, Orozco JIJ, Iniguez-Munoz S, Salomon MP, Sese B, et al. Current triple-negative breast cancer subtypes: dissecting the most aggressive form of breast cancer. Front Oncol. 2021;11: 681476.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Waks AG, Winer EP. Breast cancer treatment: a review. JAMA. 2019;321(3):288–300.

Article  CAS  PubMed  Google Scholar 

Almansour NM. Triple-negative breast cancer: a brief review about epidemiology, risk factors, signaling pathways, treatment and role of artificial intelligence. Front Mol Biosci. 2022;9: 836417.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yin J, Zhu C, Wang G, Gu J. Treatment for triple-negative breast cancer: an umbrella review of meta-analyses. Int J Gen Med. 2022;15:5901–14.

Article  PubMed  PubMed Central  Google Scholar 

Loddo M, Andryszkiewicz J, Rodriguez-Acebes S, Stoeber K, Jones A, Dafou D, et al. Pregnancy-associated plasma protein A regulates mitosis and is epigenetically silenced in breast cancer. J Pathol. 2014;233(4):344–56.

Article  CAS  PubMed  Google Scholar 

Park AL, Huang T, Meschino WS, Iqbal J, Ray JG. Prenatal biochemical screening and a woman’s long-term risk of cancer: a population-based cohort study. JNCI Cancer Spectr. 2020;4(1):pkz077.

Article  PubMed  Google Scholar 

Laursen LS, Overgaard MT, Weyer K, Boldt HB, Ebbesen P, Christiansen M, et al. Cell surface targeting of pregnancy-associated plasma protein A proteolytic activity. Reversible adhesion is mediated by two neighboring short consensus repeats. J Biol Chem. 2002;277(49):47225–34.

Article  CAS  PubMed 

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