KEB received funding to the institution for preclinical research from Pionyr. Other funding to the institution including BMS-LCFA-IASLC YIA, Aravive, and Arsenal Bio. Consultant for Alpine Bioscience, Aravive, Aveo, Astrazeneca, BMS, Eisai, Exelixis, Merck, Nimbus, Sanofi, Seagen. BB is supported by the Defense Congressionally Directed Medical Research Program # W81XWH-22-1-0208. BB served on advisory board for Merck/ Eisai and reports research funding to institution from Amgen, Artios, Bicycle therapeutics, Boehringer Ingelheim, Elucida Oncology, Gritstone Bio, Ikena Oncology, Jazz pharmaceuticals, KAHR medical, Lyell immunopharma, Merck, RASCAL therapeutics, Syros pharmaceuticals, Tarveda therapeutics, all outside the submitted. Institutional research support by Pionyr immunopharma related to this work. CEK has received research support from Sanofi-Aventis, Gilead Sciences, Incyte Corporation, Pionyr Immunopharma, AstraZeneca, Merck, BMS. CEK has served on advisory board for Sanofi-Aventis, Exelixis, AVEO pharmaceuticals, Janssen.