Mu Y, Zhou CH, Chen SF, Ding J, Zhang YX, Yang YP et al (2016) Effectiveness and safety of chemotherapy combined with cytokine-induced killer cell /dendritic cell-cytokine-induced killer cell therapy for treatment of gastric cancer in China: a systematic review and meta-analysis. Cytotherapy 18(9):1162–1177
Article CAS PubMed Google Scholar
Chen W, Zheng R, Zeng H, Zhang S, He J (2015) Annual report on status of cancer in China, 2011. Chin J Cancer Res = Chung-kuo yen cheng yen chiu 27(1):2–12
Kalniņa Z, Meistere I, Kikuste I, Tolmanis I, Zayakin P, Linē A (2015) Emerging blood-based biomarkers for detection of gastric cancer. World J Gastroenterol 21(41):11636–11653
Article PubMed PubMed Central Google Scholar
Hamashima C (2014) Current issues and future perspectives of gastric cancer screening. World J Gastroenterol 20(38):13767–13774
Article PubMed PubMed Central Google Scholar
Digklia A, Wagner AD (2016) Advanced gastric cancer: current treatment landscape and future perspectives. World J Gastroenterol 22(8):2403–2414
Article CAS PubMed PubMed Central Google Scholar
Wagner AD, Syn NL, Moehler M, Grothe W, Yong WP, Tai BC et al (2017) Chemotherapy for advanced gastric cancer. Cochrane Database Syst Rev 8(8):Cd004064
Mellman I, Coukos G, Dranoff G (2011) Cancer immunotherapy comes of age. Nature 480(7378):480–489
Article ADS CAS PubMed PubMed Central Google Scholar
Zhao J, Zhang X, Gong C, Zhang J (2017) Targeted therapy with apatinib in a patient with relapsed small cell lung cancer: a case report and literature review. Medicine 96(50):e9259
Article PubMed PubMed Central Google Scholar
Fontanella C, Ongaro E, Bolzonello S, Guardascione M, Fasola G, Aprile G (2014) Clinical advances in the development of novel VEGFR2 inhibitors. Ann Transl Med 2(12):123
PubMed PubMed Central Google Scholar
Ferrara N, Gerber HP, LeCouter J (2003) The biology of VEGF and its receptors. Nat Med 9(6):669–676
Article CAS PubMed Google Scholar
Lee SH, Jeong D, Han YS, Baek MJ (2015) Pivotal role of vascular endothelial growth factor pathway in tumor angiogenesis. Ann Surg Treat Res 89(1):1–8
Article PubMed PubMed Central Google Scholar
Roviello G, Ravelli A, Polom K, Petrioli R, Marano L, Marrelli D et al (2016) Apatinib: a novel receptor tyrosine kinase inhibitor for the treatment of gastric cancer. Cancer Lett 372(2):187–191
Article CAS PubMed Google Scholar
Zhang H (2015) Apatinib for molecular targeted therapy in tumor. Drug Des Dev Ther 9:6075–6081
Article ADS CAS Google Scholar
Bang Y-J, Van Cutsem E, Feyereislova A, Chung HC, Shen L, Sawaki A et al (2010) Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. The Lancet 376(9742):687–697
Ychou M, Boige V, Pignon J-P, Conroy T, Bouché O, Lebreton G et al (2011) Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: an FNCLCC and FFCD multicenter phase III trial. J Clin Oncol 29(13):1715–1721
Article CAS PubMed Google Scholar
Fuchs CS, Doi T, Jang RW, Muro K, Satoh T, Machado M et al (2018) Safety and efficacy of pembrolizumab monotherapy in patients with previously treated advanced gastric and gastroesophageal junction cancer: phase 2 clinical KEYNOTE-059 trial. JAMA Oncol 4(5):e180013
Article PubMed PubMed Central Google Scholar
Kang Y-K, Boku N, Satoh T, Ryu M-H, Chao Y, Kato K et al (2017) Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial. The Lancet 390(10111):2461–2471
Zhu AX, Finn RS, Edeline J, Cattan S, Ogasawara S, Palmer D et al (2018) Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib (KEYNOTE-224): a non-randomised, open-label phase 2 trial. Lancet Oncol 19(7):940–952
Antonia SJ, Villegas A, Daniel D, Vicente D, Murakami S, Hui R et al (2017) Durvalumab after chemoradiotherapy in stage III non-small-cell lung cancer. N Engl J Med 377(20):1919–1929
Article CAS PubMed Google Scholar
Apolo AB, Infante JR, Balmanoukian A, Patel MR, Wang D, Kelly K et al (2017) Avelumab, an anti-programmed death-ligand 1 antibody, in patients with refractory metastatic urothelial carcinoma: results from a multicenter, phase Ib study. J Clin Oncol Offic J Am Soc Clin Oncol 35(19):2117–2124
Feng Y, Dai Y, Gong Z, Cheng JN, Zhang L, Sun C et al (2018) Association between angiogenesis and cytotoxic signatures in the tumor microenvironment of gastric cancer. Onco Targets Ther 11:2725–2733
Article PubMed PubMed Central Google Scholar
Yi M, Jiao D, Qin S, Chu Q, Wu K, Li A (2019) Synergistic effect of immune checkpoint blockade and anti-angiogenesis in cancer treatment. Mol Cancer 18(1):60
Article PubMed PubMed Central Google Scholar
Shitara K, Özgüroğlu M, Bang Y-J, Di Bartolomeo M, Mandalà M, Ryu M-H et al (2018) Pembrolizumab versus paclitaxel for previously treated, advanced gastric or gastro-oesophageal junction cancer (KEYNOTE-061): a randomised, open-label, controlled, phase 3 trial. The Lancet 392(10142):123–133
Tabernero J, Bang Y-J, Fuchs CS, Ohtsu A, Kher U, Lam B et al (2016) KEYNOTE-062: Phase III study of pembrolizumab (MK-3475) alone or in combination with chemotherapy versus chemotherapy alone as first-line therapy for advanced gastric or gastroesophageal junction (GEJ) adenocarcinoma. J Clin Oncol 34:TPS185-TPS185
Janjigian YY, Shitara K, Moehler M, Garrido M, Salman P, Shen L et al (2021) First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, open-label, phase 3 trial. The Lancet 398(10294):27–40
Zhou N, Zhang C, Liu D, Liu K, Wang G, Zhu H et al (2021) Apatinib in combination with S-1 as first-line treatment in patients with advanced metastatic gastric cancer: results from an open, exploratory, single-arm, phase II trial. Oncologist 26(3):e374–e381
Article CAS PubMed Google Scholar
Peng Z, Wei J, Wang F, Ying J, Deng Y, Gu K et al (2021) Camrelizumab combined with chemotherapy followed by camrelizumab plus apatinib as first-line therapy for advanced gastric or gastroesophageal junction adenocarcinoma. Clin. Cancer Res Offic J Am Assoc Cancer Res 27(11):3069–3078
Tang Z, Wang Y, Yu Y, Cui Y, Liang L, Xu C et al (2022) Neoadjuvant apatinib combined with oxaliplatin and capecitabine in patients with locally advanced adenocarcinoma of stomach or gastroesophageal junction: a single-arm, open-label, phase 2 trial. BMC Med 20(1):107
Article CAS PubMed PubMed Central Google Scholar
Xu C, Xie X, Kang N, Jiang H (2023) Neoadjuvant PD-1 inhibitor and apatinib combined with S-1 plus oxaliplatin for locally advanced gastric cancer patients: a multicentered, prospective, cohort study. J Cancer Res Clin Oncol 149(7):4091–4099
Article CAS PubMed Google Scholar
Pan L, Tian Y, Wang K, Tang J, Liu J, Zhang J et al (2022) Low-dose apatinib combined with camrelizumab and the SOX regimen in the neoadjuvant treatment of locally advanced gastric/gastroesophageal junction adenocarcinoma (SPACE-neo): a protocol for an open-label, single-arm, clinical trial. J Gastrointest Oncol 13(6):3300–3313
Article PubMed PubMed Central Google Scholar
Xiong H, Li Y (2023) Neoadjuvant PD-1 inhibitor plus apatinib and chemotherapy versus apatinib plus chemotherapy versus chemotherapy alone in patients with locally advanced gastric cancer. Am J Cancer Res 13(8):3559–3570
PubMed PubMed Central Google Scholar
Zhao D, Hou H, Zhang X (2018) Progress in the treatment of solid tumors with apatinib: a systematic review. Onco Targets Ther 11:4137–4147
留言 (0)