Roth GA, Johnson C, Abajobir A, Abd-Allah F, Abera SF, Abyu G, et al. Global, regional, and national burden of cardiovascular diseases for 10 causes, 1990 to 2015. J Am Coll Cardiol. 2017;70:1–25.

Article  PubMed  PubMed Central  Google Scholar 

Thacker EL, Gillett SR, Wadley VG, Unverzagt FW, Judd SE, McClure LA, et al. The American Heart Association Life’s simple 7 and incident cognitive impairment: the re asons for geographic and racial differences in stroke (REGARDS) study. J Am Heart Assoc. 2014;3:e000635.

Article  PubMed  PubMed Central  Google Scholar 

Lloyd-Jones DM, Hong Y, Labarthe D, Mozaffarian D, Appel LJ, Van Horn L, et al. Defining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association’s strategic Impact Goal through 2020 and beyond. Circulation. 2010;121:586–613.

Article  PubMed  Google Scholar 

Kulshreshtha A, Vaccarino V, Judd SE, Howard VJ, McClellan WM, Muntner P, et al. Life’s Simple 7 and risk of incident stroke: the reasons for geographic and racial differences in stroke study. Stroke. 2013;44:1909–14.

Article  PubMed  Google Scholar 

Folsom AR, Olson NC, Lutsey PL, Roetker NS, Cushman M. American Heart Association’s Life’s Simple 7 and incidence of venous thromboembolism. Am J Hematol. 2015;90:E92.

Article  PubMed  PubMed Central  Google Scholar 

Wu J, Xiong Y, Xia X, Orsini N, Qiu C, Kivipelto M, et al. Can dementia risk be reduced by following the American Heart Association’s Life’s Simple 7? A systematic review and dose-response meta-analysis. Ageing Res Rev. 2023;83:101788.

Article  CAS  PubMed  Google Scholar 

Conroy RM, Pyörälä K, Fitzgerald A, Sans S, Menotti A, De Backer G, et al. Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project. Eur Heart J. 2003;24:987–1003.

Article  CAS  PubMed  Google Scholar 

Enserro DM, Vasan RS, Xanthakis V. Twenty‐year trends in the American Heart Association cardiovascular health score and impact on subclinical and clinical cardiovascular disease: the Framingham Offspring Study. J Am Heart Assoc. 2018;7:e008741.

Article  PubMed  PubMed Central  Google Scholar 

Becerra-Tomás N, Blanco Mejía S, Viguiliouk E, Khan T, Kendall CW, Kahleova H, et al. Mediterranean diet, cardiovascular disease and mortality in diabetes: A systematic review and meta-analysis of prospective cohort studies and randomized clinical trials. Crit Rev food Sci Nutr. 2020;60:1207–27.

Article  PubMed  Google Scholar 

Davey GK, Spencer EA, Appleby PN, Allen NE, Knox KH, Key TJ. EPIC–Oxford: lifestyle characteristics and nutrient intakes in a cohort of 33 883 meat-eaters and 31 546 non-meat-eaters in the UK. Public health Nutr. 2003;6:259–68.

Article  PubMed  Google Scholar 

Knorr D, Clancy KL. Safety aspects of processed foods. Food security in the United States: CRC Press; 2021. p. 231–53.

Melough MM, Maffini MV, Otten JJ, Sathyanarayana S. Diet quality and exposure to endocrine-disrupting chemicals among US adults. Environ Res. 2022;211:113049.

Article  CAS  PubMed  Google Scholar 

Petrus RR, do Amaral Sobral PJ, Tadini CC, Gonçalves CB. The NOVA classification system: A critical perspective in food science. Trends Food Sci Technol 2021;116:603–8.

Article  CAS  Google Scholar 

Monteiro CA, Cannon G, Levy RB, Moubarac JC, Louzada ML, Rauber F, et al. Ultra-processed foods: what they are and how to identify them. Public Health Nutr. 2019;22:936–41.

Article  PubMed  PubMed Central  Google Scholar 

Chen X, Zhang Z, Yang H, Qiu P, Wang H, Wang F, et al. Consumption of ultra-processed foods and health outcomes: a systematic review of epidemiological studies. Nutr J. 2020;19:1–10.

Article  CAS  Google Scholar 

Cediel G, Reyes M, da Costa Louzada ML, Steele EM, Monteiro CA, Corvalán C, et al. Ultra-processed foods and added sugars in the Chilean diet (2010). Public health Nutr. 2018;21:125–33.

Article  PubMed  Google Scholar 

Juul F, Vaidean G, Parekh N. Ultra-processed foods and cardiovascular diseases: potential mechanisms of action. Adv Nutr. 2021;12:1673–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barbosa SS, Sousa LCM, de Oliveira Silva DF, Pimentel JB, Evangelista KCMDS, Lyra CDO, et al. A systematic review on processed/ultra-processed foods and arterial hypertension in adults and older people. Nutrients. 2022;14:1215.

Article  PubMed  PubMed Central  Google Scholar 

Bonaccio M, Di Castelnuovo A, Costanzo S, De Curtis A, Persichillo M, Sofi F, et al. Ultra-processed food consumption is associated with increased risk of all-cause and cardiovascular mortality in the Moli-sani Study. Am J Clin Nutr. 2021;113:446–55.

Article  CAS  PubMed  Google Scholar 

Ha AW, Kim WK. The food and nutrient intakes from daily processed food in Korean adults: based on the 6th Korea National Health and Nutrition Examination Survey data (2013–2015). J Nutr Health. 2019;52.5:422–34.

Monteiro CA, Cannon G, Lawrence M, Costa Louzada MD, Pereira Machado P. Ultra-processed foods, diet quality, and health using the NOVA classification system. Rome: FAO. 2019;48.

Lloyd-Jones DM. Improving the cardiovascular health of the US population. Jama. 2012;307:1314–6.

Article  CAS  PubMed  Google Scholar 

Chen X, Zhang Z, Yang H, Qiu P, Wang H, Wang F, et al. Consumption of ultra-processed foods and health outcomes: a systematic review of epidemiological studies. Nutr J. 2020;19:86.

Article  PubMed  PubMed Central  Google Scholar 

Wansink B, Cheney MM, Chan N. Exploring comfort food preferences across age and gender. Physiol Behav. 2003;79:739–47.

Article  CAS  PubMed  Google Scholar 

Zhong G-C, Gu H-T, Peng Y, Wang K, Wu Y-Q-L, Hu T-Y, et al. Association of ultra-processed food consumption with cardiovascular mortality in the US population: long-term results from a large prospective multicenter study. Int J Behav Nutr Phys Act. 2021;18:1–14.

Article  ADS  Google Scholar 

Steele EM, Juul F, Neri D, Rauber F, Monteiro CA. Dietary share of ultra-processed foods and metabolic syndrome in the US adult population. Prev Med. 2019;125:40–8.

Article  Google Scholar 

Srour B, Fezeu LK, Kesse-Guyot E, Allès B, Méjean C, Andrianasolo RM, et al. Ultra-processed food intake and risk of cardiovascular disease: prospective cohort study (NutriNet-Santé). BMJ. 2019;365:1451.

Srour B, Fezeu LK, Kesse-Guyot E, Alles B, Mejean C, Andrianasolo RM, et al. Ultra-processed food intake and risk of cardiovascular disease: prospective cohort study (NutriNet-Sante). BMJ. 2019;365:l1451.

Article  PubMed  PubMed Central  Google Scholar 

Salomé M, Arrazat L, Wang J, Dufour A, Dubuisson C, Volatier J-L, et al. Contrary to ultra-processed foods, the consumption of unprocessed or minimally processed foods is associated with favorable patterns of protein intake, diet quality and lower cardiometabolic risk in French adults (INCA3). Eur J Nutr. 2021;60:4055–67.

Article  PubMed  Google Scholar 

de Jesus Santana G, de Jesus Silva N, Costa JO, Vásquez CMP, Vila-Nova TMS, Vieira DADS, et al. Contribution of minimally processed and ultra-processed foods to the cardiometabolic risk of Brazilian young adults: a cross-sectional study. nutrición hospitalaria: Organo oficial de la Soc española de nutrición Parenter y Enter. 2021;38:328–36.

Google Scholar 

Canhada SL, Vigo Á, Luft VC, Levy RB, Alvim Matos SM, del Carmen Molina M, et al. Ultra-processed food consumption and increased risk of metabolic Syndrome in adults: The ELSA-Brasil. Diabetes Care. 2022;46:369–76.

Article  PubMed Central  Google Scholar 

Hall KD, Ayuketah A, Brychta R, Cai H, Cassimatis T, Chen KY, et al. Ultra-processed diets cause excess calorie intake and weight gain: an inpatient randomized controlled trial of ad libitum food intake. Cell Metab. 2019;30:67–77.e3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Casagrande SS, Cowie CC. Trends in dietary intake among adults with type 2 diabetes: NHANES 1988–2012. J Hum Nutr Diet. 2017;30:479–89.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luiten CM, Steenhuis IH, Eyles H, Mhurchu CN, Waterlander WE. Ultra-processed foods have the worst nutrient profile, yet they are the most available packaged products in a sample of New Zealand supermarkets. Public health Nutr. 2016;19:530–8.

Article  PubMed  Google Scholar 

Mozaffarian D. Dietary and policy priorities for cardiovascular disease, diabetes, and obesity: a comprehensive review. Circulation. 2016;133:187–225.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hooper L, Martin N, Jimoh OF, Kirk C, Foster E, Abdelhamid AS. Reduction in saturated fat intake for cardiovascular disease. Cochrane database of systematic reviews. 2020;8:CD011737.

Robinson E, Almiron-Roig E, Rutters F, de Graaf C, Forde CG, Tudur Smith C, et al. A systematic review and meta-analysis examining the effect of eating rate on energy intake and hunger. Am J Clin Nutr. 2014;100:123–51.

Article  CAS  PubMed  Google Scholar 

Zhang Y, Huang M, Zhuang P, Jiao J, Chen X, Wang J, et al. Exposure to acrylamide and the risk of cardiovascular diseases in the National Health and Nutrition Examination Survey 2003–2006. Environ Int. 2018;117:154–63.

Article  CAS  Google Scholar 

Chassaing B, Koren O, Goodrich JK, Poole AC, Srinivasan S, Ley RE, et al. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature. 2015;519:92–6.

Article  ADS  CAS  PubMed Central  Google Scholar 

Ong H-T, Samsudin H, Soto-Valdez H. Migration of endocrine-disrupting chemicals into food from plastic packaging materials: an overview of chemical risk assessment, techniques to monitor migration, and international regulations. Crit Rev Food Sci Nutr. 2022;62:957–79.

Article  CAS  PubMed  Google Scholar 

Singh K, Ahluwalia P. Effect of monosodium glutamate on lipid peroxidation and certain antioxidant enzymes in cardiac tissue of alcoholic adult male mice. J Cardiovasc Dis Res. 2012;3:12–8.