Allaman, I., Bélanger, M., & Magistretti, P. J. (2011). Astrocyte-neuron metabolic relationships: For better and for worse. Trends in Neurosciences, 34(2), 76–87. https://doi.org/10.1016/j.tins.2010.12.001.

Article  CAS  PubMed  Google Scholar 

Cai, L., Gong, Q., Qi, L., Xu, T., Suo, Q., Li, X., et al. (2022). ACT001 attenuates microglia-mediated neuroinflammation after traumatic brain injury via inhibiting AKT/NFκB/NLRP3 pathway. Cell Communication and Signaling, 20(1), 1–23. https://doi.org/10.1186/s12964-022-00862-y.

Article  CAS  Google Scholar 

Chi, H., Barry, S. P., Roth, R. J., Wu, J. J., Jones, E. A., Bennett, A. M., & Flavell, R. A. (2006). Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Proc Natl Acad Sci U S A, 103(7), 2274–2279. https://doi.org/10.1073/pnas.0510965103.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choi, J. H., Jang, M., Lee, J., Il, Chung, W. S., & Cho, I. H. (2018). Neuroprotective effects of a traditional multi-herbal medicine kyung-ok-ko in an animal model of parkinson’s disease: Inhibition of mapks and nf-kb pathways and activation of keap1-nrf2 pathway. Frontiers in Pharmacology, 9(December), 1–15. https://doi.org/10.3389/fphar.2018.01444.

Article  CAS  Google Scholar 

Colucci-D’Amato, L., Perrone-Capano, C., & Di Porzio, U. (2003). Chronic activation of ERK and neurodegenerative diseases. Bioessays, 25(11), 1085–1095. https://doi.org/10.1002/bies.10355.

Article  CAS  PubMed  Google Scholar 

Fang, J. Y., & Richardson, B. C. (2005). The MAPK signalling pathways and colorectal cancer. Lancet Oncology, 6(5), 322–327. https://doi.org/10.1016/S1470-2045(05)70168-6.

Article  CAS  PubMed  Google Scholar 

Germann, U. A., Furey, B. F., Markland, W., Hoover, R. R., Aronov, A. M., Roix, J. J., et al. (2017). Targeting the MAPK signaling pathway in cancer: Promising preclinical activity with the novel selective ERK1/2 inhibitor BVD-523 (ulixertinib). Molecular Cancer Therapeutics, 16(11), 2351–2363. https://doi.org/10.1158/1535-7163.MCT-17-0456.

Article  CAS  PubMed  Google Scholar 

Ghose, A. K., Herbertz, T., Hudkins, R. L., Dorsey, B. D., & Mallamo, J. P. (2012). Knowledge-based, central nervous system (CNS) lead selection and lead optimization for CNS drug discovery. Acs Chemical Neuroscience, 3(1), 50–68. https://doi.org/10.1021/cn200100h.

Article  CAS  PubMed  Google Scholar 

Guo, Y., Pan, W., Liu, S., Shen, Z., Xu, Y., & Hu, L. (2020). ERK/MAPK signalling pathway and tumorigenesis (review). Exp Ther Med, 1997–2007. https://doi.org/10.3892/etm.2020.8454.

Hansson, E. (2010). Long-term pain, neuroinflammation and glial activation. Scand J Pain, 1(2), 67–72. https://doi.org/10.1016/j.sjpain.2010.01.002.

Article  PubMed  Google Scholar 

Hong, D. G., Lee, S., Kim, J., Yang, S., Lee, M., Ahn, J., et al. (2022). Anti-inflammatory and neuroprotective effects of Morin in an MPTP-Induced Parkinson’s Disease Model. International Journal of Molecular Sciences, 23(18). https://doi.org/10.3390/ijms231810578.

Jankovic, J. (2008). Parkinson’s disease: Clinical features and diagnosis. Journal of Neurology, Neurosurgery and Psychiatry, 79(4), 368–376. https://doi.org/10.1136/jnnp.2007.131045.

Article  CAS  PubMed  Google Scholar 

Jo, J., Lee, D., Park, Y. H., Choi, H., Han, J., Park, D. H., et al. (2021). Discovery and optimization of novel 3-benzyl-N-phenyl-1H-pyrazole-5-carboxamides as bifunctional antidiabetic agents stimulating both insulin secretion and glucose uptake. European Journal of Medicinal Chemistry, 217, 113325. https://doi.org/10.1016/j.ejmech.2021.113325.

Article  CAS  PubMed  Google Scholar 

Kaminska, B. (2005). MAPK signalling pathways as molecular targets for anti-inflammatory therapy - from molecular mechanisms to therapeutic benefits. Biochim Biophys Acta Proteins Proteom, 1754(1–2), 253–262. https://doi.org/10.1016/j.bbapap.2005.08.017.

Article  CAS  Google Scholar 

Kempuraj, D., Thangavel, R., Natteru, P. A., Selvakumar, G. P., Saeed, D., Zahoor, H., et al. (2016). Neuroinflammation induces neurodegeneration. J Neurol Neurosurg Spine, 1(1), 1003.

PubMed  PubMed Central  Google Scholar 

Kirkley, K. S., Popichak, K. A., Hammond, S. L., Davies, C., Hunt, L., & Tjalkens, R. B. (2019). Genetic suppression of IKK2/NF-κB in astrocytes inhibits neuroinflammation and reduces neuronal loss in the MPTP-Probenecid model of Parkinson’s disease. Neurobiology of Diseases, 127(November 2018), 193–209. https://doi.org/10.1016/j.nbd.2019.02.020.

Article  CAS  Google Scholar 

Koelblinger, P., Dornbierer, J., & Dummer, R. (2017). A review of binimetinib for the treatment of mutant cutaneous melanoma. Future Oncology, 13(20), 1–12. https://doi.org/10.2217/fon-2017-0170.

Article  CAS  Google Scholar 

Kwon, H. S., & Koh, S. H. (2020). Neuroinflammation in neurodegenerative disorders: The roles of microglia and astrocytes. Transl Neurodegener, 9(1), 1–12. https://doi.org/10.1186/s40035-020-00221-2.

Article  Google Scholar 

Latif, S., Jahangeer, M., Maknoon Razia, D., Ashiq, M., Ghaffar, A., Akram, M., et al. (2021). Dopamine in Parkinson’s disease. Clinica Chimica Acta. https://doi.org/10.1016/j.cca.2021.08.009.

Article  Google Scholar 

Lee, Y., Lee, S., Chang, S. C., & Lee, J. (2019). Significant roles of neuroinflammation in Parkinson’s disease: Therapeutic targets for PD prevention. Archives of Pharmacal Research, 42(5), 416–425. https://doi.org/10.1007/s12272-019-01133-0.

Article  CAS  PubMed  Google Scholar 

Lee, S., Suh, Y. J., Lee, Y., Yang, S., Hong, D. G., Thirumalai, D., et al. (2021). Anti-inflammatory effects of the novel barbiturate derivative MHY2699 in an mptp‐induced mouse model of parkinson’s disease. Antioxidants, 10(11). https://doi.org/10.3390/antiox10111855.

Lee, S., Hong, D. G., Yang, S., Kim, J., Baek, M., Kim, S., et al. (2022). Anti-inflammatory effect of IKK‐Activated GSK‐3β inhibitory peptide prevented Nigrostriatal Neurodegeneration in the Rodent Model of Parkinson’s Disease. International Journal of Molecular Sciences, 23(2). https://doi.org/10.3390/ijms23020998.

Li, Q., & Barres, B. A. (2018). Microglia and macrophages in brain homeostasis and disease. Nature Reviews Immunology. https://doi.org/10.1038/nri.2017.125.

Article  PubMed  Google Scholar 

Li, Y., Chen, N., Wu, C., Lu, Y., Gao, G., Duan, C., et al. (2020). Galectin-1 attenuates neurodegeneration in Parkinson’s disease model by modulating microglial MAPK/IκB/NFκB axis through its carbohydrate-recognition domain. Brain, Behavior, and Immunity, 83, 214–225. https://doi.org/10.1016/j.bbi.2019.10.015.

Article  CAS  PubMed  Google Scholar 

Liu, T., Zhang, L., Joo, D., & Sun, S. C. (2017). NF-κB signaling in inflammation. Signal Transduct Target Ther, 2(April), https://doi.org/10.1038/sigtrans.2017.23.

Liu, B., Zhang, Y., Yang, Z., Liu, M., Zhang, C., Zhao, Y., & Song, C. (2021). ω-3 DPA protected neurons from Neuroinflammation by balancing Microglia M1/M2 polarizations through inhibiting NF-κB/MAPK p38 signaling and activating Neuron-BDNF-PI3K/AKT pathways. Marine Drugs, 19(11). https://doi.org/10.3390/md19110587.

Ma, X. L., Chen, C., & Yang, J. (2005). Predictive model of blood-brain barrier penetration of organic compounds. Acta Pharmacologica Sinica, 26(4), 500–512. https://doi.org/10.1111/j.1745-7254.2005.00068.x.

Article  CAS  PubMed  Google Scholar 

Madhi, I., Kim, J. H., Shin, J. E., & Kim, Y. (2021). Ginsenoside re exhibits neuroprotective effects by inhibiting neuroinflammation via CAMK/MAPK/NF-κB signaling in microglia. Molecular Medicine Reports, 24(4), 1–10. https://doi.org/10.3892/mmr.2021.12337.

Article  CAS  Google Scholar 

Marsili, L., Marconi, R., & Colosimo, C. (2017). Treatment Strategies in Early Parkinson’s Disease. Int Rev Neurobiol (1st ed., Vol. 132). Elsevier Inc. https://doi.org/10.1016/bs.irn.2017.01.002.

Mebratu, Y., & Tesfaigzi, Y. (2009). How ERK1/2 activation controls cell proliferation and cell death is subcellular localization the answer? Cell Cycle, 8(8), 1168–1175.

Article  CAS  PubMed  Google Scholar 

Mishima, K., Inoue, K., & Hayashi, Y. (2002). Overexpression of extracellular-signal regulated kinases on oral squamous cell carcinoma. Oral Oncology, 38(5), 468–474. https://doi.org/10.1016/S1368-8375(01)00104-X.

Article  CAS  PubMed  Google Scholar 

Novak, M. L., & Koh, T. J. (2013). Macrophage phenotypes during tissue repair. Journal of Leukocyte Biology, 93(6). https://doi.org/10.1189/jlb.1012512.

Oeckinghaus, A., Hayden, M. S., & Ghosh, S. (2011). Crosstalk in NF-κB signaling pathways. Nature Immunology, 12(8), 695–708. https://doi.org/10.1038/ni.2065.

Article  CAS  PubMed  Google Scholar 

Ohori, M. (2008). ERK inhibitors as a potential new therapy for rheumatoid arthritis. Drug News & Perspectives, 21(5). https://doi.org/10.1358/DNP.2008.21.5.1219006.

Olah, M., Biber, K., Vinet, J., & Boddeke, W. G. M., H (2011). Microglia phenotype diversity. CNS Neurol Disord Drug Targets, 10(1). https://doi.org/10.2174/187152711794488575.

Orihuela, R., McPherson, C. A., & Harry, G. J. (2016). Microglial M1/M2 polarization and metabolic states. British Journal of Pharmacology. https://doi.org/10.1111/bph.13139.

Article  PubMed  Google Scholar 

Rai, S. N., Birla, H., Singh, S. S., Zahra, W., Patil, R. R., Jadhav, J. P., et al. (2017). Mucuna pruriens protects against MPTP intoxicated neuroinflammation in Parkinson’s disease through NF-κB/pAKT signaling pathways. Frontiers in Aging Neuroscience, 9(DEC), 1–14. https://doi.org/10.3389/fnagi.2017.00421.

Article  CAS  Google Scholar 

Rai, S. N., Dilnashin, H., Birla, H., Singh, S. S., Zahra, W., Rathore, A. S., et al. (2019). The role of PI3K/Akt and ERK in Neurodegenerative disorders. Neurotoxicity Research, 35(3), 775–795. https://doi.org/10.1007/s12640-019-0003-y.

Article  CAS  PubMed  Google Scholar 

Shechter, R., Miller, O., Yovel, G., Rosenzweig, N., London, A., Ruckh, J., et al. (2013). Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by Remote Brain Choroid Plexus. Immunity, 38(3). https://doi.org/10.1016/j.immuni.2013.02.012.

Sugiura, R., Satoh, R., & Takasaki, T. (2021). Erk: A double-edged sword in cancer. Erk-dependent apoptosis as a potential therapeutic strategy for cancer. Cells, 10(10). https://doi.org/10.3390/cells10102509.

Tang, Y., & Le, W. (2016). Differential roles of M1 and M2 microglia in neurodegenerative diseases. Molecular Neurobiology. https://doi.org/10.1007/s12035-014-9070-5.

Article  PubMed  PubMed Central  Google Scholar 

Tran, K. A., Cheng, M. Y., Mitra, A., Ogawa, H., Shi, V. Y., Olney, L. P., et al. (2015). MEK inhibitors and their potential in the treatment of advanced melanoma: The advantages of combination therapy. Drug Design, Development and Therapy, 10, 43–52. https://doi.org/10.2147/DDDT.S93545.

Article  PubMed  PubMed Central  Google Scholar 

Tysnes, O. B., & Storstein, A. (2017). Epidemiology of Parkinson’s disease. Journal of Neural Transmission (Vienna, Austria : 1996), 124(8), 901–905. https://doi.org/10.1007/s00702-017-1686-y.

Article  PubMed  Google Scholar 

Vila, M., Jackso