Al-Dhalimi MA, Al-Janabi MH. Split lesion randomized comparative study between long pulsed Nd:YAG laser 532 and 1,064 nm in treatment of facial port-wine stain. Lasers Surg Med. 2016;48(9):852–8.

Article  PubMed  Google Scholar 

Chen JK, Ghasri P, Aguilar G, Drooge AMv, Wolkerstorfer A, Kelly KM, et al. An overview of clinical and experimental treatment modalities for port wine stains. J Am Acad Dermatol. 2012;67(2):289–304.

Article  PubMed  PubMed Central  Google Scholar 

Horbach SER, Rigter IM, Smitt JHS, Reekers JA, Spuls PI, Horst CMAMvd. Intralesional bleomycin injections for vascular malformations: a systematic review and meta-analysis. Plastic Reconstr Surg. 2016;137(1):244–56.

Article  CAS  Google Scholar 

Lokhorst MM, Jolink F, Horbach SER, Spuls PI, Horst CMAMvd. Surgical treatment of peripheral vascular malformations: a systematic review and meta-analysis. Plastic Reconstr Surg. 2021;147(5):1149–61.

Article  CAS  Google Scholar 

Adams DM, Trenor CC, Hammill AM, Vinks AA, Patel MN, Chaudry G, et al. Efficacy and safety of sirolimus in the treatment of complicated vascular anomalies. Pediatrics. 2016;137(2): e20153257.

Article  PubMed  PubMed Central  Google Scholar 

Triana P, Dore M, Cerezo VN, Cervantes M, Sánchez AV, Ferrero MM, et al. Sirolimus in the treatment of vascular anomalies. Eur J Pediatr Surg. 2017;27(1):86–90.

PubMed  Google Scholar 

Harbers VEM, Rongen GAPJM, Vleuten CJMvD, Verhoeven BH, Laat PCJd, Horst CM, et al. Patients with congenital low-flow vascular malformation treated with low dose sirolimus. Adv Therapy. 2021;38(6):3465–82.

Article  CAS  Google Scholar 

Freixo C, Ferreira V, Martins J, Almeida R, Caldeira D, Rosa M, et al. Efficacy and safety of sirolimus in the treatment of vascular anomalies: a systematic review. J Vasc Surg. 2020;71(1):318–27.

Article  PubMed  Google Scholar 

Bevacqua M, Baldo F, Pastore S, Valencic E, Tommasini A, Maestro A, et al. Off-label use of sirolimus and everolimus in a pediatric center: a case series and review of the literature. Paediatr Drugs. 2019;21(3):185–93.

Article  PubMed  CAS  Google Scholar 

Zhang Z, Li Y, Zhang G, Yang K, Qiu T, Zhou J, et al. Safety evaluation of oral sirolimus in the treatment of childhood diseases: a systematic review. Children (Basel, Switzerland). 2022;9(9):1925.

Google Scholar 

Li H, Ji J, Du Y, Huang Y, Gu H, Chen M, et al. Sirolimus is effective for primary relapsed/refractory autoimmune cytopenia: a multicenter study. Exp Hematol. 2020;89:87–95.

Article  PubMed  CAS  Google Scholar 

Hicks CL, Baeyer CLV, Spafford PA, Korlaar Iv, Goodenough B. The Faces Pain Scale-revised: toward a common metric in pediatric pain measurement. Pain. 2001;93(2):173–83.

Article  PubMed  Google Scholar 

Li W, Qing Z, Jun C, Bifa F, Chongrong G, Li H, et al. Expert consensus on the application of pain evaluation questionnaires in China (2020). Chin J Painol. 2020;03:177–87.

Google Scholar 

Shirazi F, Cohen C, Fried L, Arbiser JL. Mammalian target of rapamycin (mTOR) is activated in cutaneous vascular malformations in vivo. Lymphat Res Biol. 2007;5(4):233–6.

Article  PubMed  CAS  Google Scholar 

Sebold AJ, Day AM, Ewen J, Adamek J, Byars A, Cohen B, et al. Sirolimus treatment in Sturge-Weber syndrome. Pediatr Neurol. 2021;115:29–40.

Article  PubMed  Google Scholar 

Ferreira J, Gutiérrez JCL, Carneiro A, Araújo A, Sousa PP, Braga S, et al. CLOVES syndrome diagnosis and treatment in an adult patient. Ann Vasc Surg. 2021;75:533.e5-e9.

Article  PubMed  Google Scholar 

Parker VER, Keppler-Noreuil KM, Faivre L, Luu M, Oden NL, Silva LD, et al. Safety and efficacy of low-dose sirolimus in the PIK3CA-related overgrowth spectrum. Genet Med. 2019;21(5):1189–98.

Article  PubMed  CAS  Google Scholar 

Filler G, Bendrick-Peart J, Christians U. Pharmacokinetics of mycophenolate mofetil and sirolimus in children. Ther Drug Monit. 2008;30(2):138–42.

Article  PubMed  CAS  Google Scholar 

Rössler J, Baselga E, Davila V, Celis V, Diociaiuti A, Hachem ME, et al. Severe adverse events during sirolimus “off-label” therapy for vascular anomalies. Pediatr Blood Cancer. 2021;68(8): e28936.

Article  PubMed  Google Scholar 

Ji Y, Chen S, Yang K, Zhou J, Zhang X, Jiang X, et al. A prospective multicenter study of sirolimus for complicated vascular anomalies. J Vasc Surg. 2021;74(5):1673-81.e3.

Article  PubMed  Google Scholar 

Zúñiga-Castillo M, Teng CL, Teng JMC. Genetics of vascular malformation and therapeutic implications. Curr Opin Pediatr. 2019;31(4):498–508.

Article  PubMed  Google Scholar 

Venot Q, Blanc T, Rabia SH, Berteloot L, Ladraa S, Duong J-P, et al. Targeted therapy in patients with PIK3CA-related overgrowth syndrome. Nature. 2018;558(7711):540–6.

Article  PubMed  PubMed Central  CAS  Google Scholar