Improving Methylphenidate Titration in Children with Attention-Deficit/Hyperactivity Disorder (ADHD): A Randomized Controlled Trial Using Placebo-Controlled Titration Implemented in Clinical Practice

Polanczyk G, de Lima MS, Horta BL, Biederman J, Rohde LA. The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry. 2007;164(6):942–8. https://doi.org/10.1176/ajp.2007.164.6.942.

Article  PubMed  Google Scholar 

Faraone SV, Asherson P, Banaschewski T, Biederman J, Buitelaar JK, Ramos-Quiroga JA, et al. Attention-deficit/hyperactivity disorder. Nat Rev. 2015;1:15020. https://doi.org/10.1038/nrdp.2015.20.

Article  Google Scholar 

Shaw M, Hodgkins P, Caci H, Young S, Kahle J, Woods AG, Arnold LE. A systematic review and analysis of long-term outcomes in attention deficit hyperactivity disorder: effects of treatment and non-treatment. BMC Med. 2012;2012(10):99. https://doi.org/10.1186/1741-7015-10-99.

Article  Google Scholar 

Luo Y, Halperin JM, Li X, Weibman D. A review of heterogeneity in attention deficit/hyperactivity disorder (ADHD). Front Hum Neurosci. 2019. https://doi.org/10.3389/fnhum.2019.00042.

Article  PubMed  PubMed Central  Google Scholar 

National Institute for Health and Care Excellence. Attention deficit hyperactivity disorder: diagnosis and management NICE guideline. 2018. http://www.nice.org.uk/guidance/ng87. Accessed 20 Nov 2022.

Wolraich ML, Hagan JF Jr, Allan C, Chan E, Davison D, Earls M, et al. Clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Pediatrics. 2019;144(4): e20192528.

Article  PubMed  Google Scholar 

Cortese S, Adamo N, Del Giovane C, Mohr-Jensen C, Hayes AJ, Carucci S, et al. Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis. Lancet Psychiatry. 2018;5(9):727–38. https://doi.org/10.1016/S2215-0366(18)30269-4.

Article  PubMed  PubMed Central  Google Scholar 

Greenhill LL, Abikoff HB, Arnold LE, Cantwell DP, Conners CK, et al. Medication treatment strategies in the MTA study: relevance to clinicians and researchers. J Am Acad Child Adolesc Psychiatry. 1996;35(10):1304–13. https://doi.org/10.1097/00004583-199610000-00017.

Article  CAS  PubMed  Google Scholar 

Vitiello B, Severe JB, Greenhill LL, et al. Methylphenidate dosage for children with ADHD over time under controlled conditions: lessons from the MTA. J Am Acad Child Adolesc Psychiatry. 2001;40(2):188–96. https://doi.org/10.1097/00004583-200102000-00013.

Article  CAS  PubMed  Google Scholar 

Vertessen K, Luman M, Swanson JM, Bottelier M, et al. Methylphenidate dose-response in children with ADHD: evidence from a double-blind, randomized placebo-controlled titration trial. Eur Child Adolesc Psychiatry. 2023. https://doi.org/10.1007/s00787-023-02176-x.

Article  PubMed  Google Scholar 

Greenhill LL, Swanson JM, Vitiello B, et al. Impairment and deportment responses to different methylphenidate doses in children with ADHD: the MTA titration trial. J Am Acad Child Adolesc Psychiatry. 2001;40(2):180–7. https://doi.org/10.1097/00004583-200102000-00012.

Article  CAS  PubMed  Google Scholar 

Medori R, Ramos-Quiroga JA, Casas M, Kooij JJ, Niemelä A, et al. A randomized, placebo-controlled trial of three fixed dosages of prolonged-release OROS methylphenidate in adults with attention-deficit/hyperactivity disorder. Biol Psychiatry. 2008;63(10):981–9. https://doi.org/10.1016/j.biopsych.2007.11.008.

Article  CAS  PubMed  Google Scholar 

Farhat LC, et al. The effects of stimulant dose and dosing strategy on treatment outcomes in attention-deficit/hyperactivity disorder in children and adolescents: a meta-analysis. Mol Psychiatry. 2022;27(3):1562–72. https://doi.org/10.1038/s41380-021-01391-9.

Article  CAS  PubMed  Google Scholar 

Rommelse N, Bunte T, Matthys W, Anderson E, Buitelaar J, Wakschlag L. Contextual variability of ADHD symptoms: embracement not erasement of a key moderating factor. Eur Child Adolesc Psychiatry. 2015;24(1):1–4. https://doi.org/10.1007/s00787-014-0665-1.

Article  PubMed  Google Scholar 

American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-5. Washington, DC: American Psychiatric Association; 2013.

Book  Google Scholar 

Canadian ADHD Resource Alliance (CADDRA). Canadian ADHD practice guidelines, 4th edn. Toronto: CADDRA; 2018. https://www.caddra.ca/wp-content/uploads/CADDRA-Guidelines-4th-Edition_-Feb2018.pdf. Accessed 20 Nov 2022.

Coghill D, Seth S. Effective management of attention-deficit/hyperactivity disorder (ADHD) through structured re-assessment: the Dundee ADHD Clinical Care Pathway. Child Adolesc Psychiatry Ment Health. 2015. https://doi.org/10.1186/s13034-015-0083-2.

Article  PubMed  PubMed Central  Google Scholar 

The MTA Cooperative Group. A 14-month randomized clinical trial of treatment strategies for attention-deficit/ hyperactivity disorder. Arch Gen Psyciatry. 1999;56(12):1073–86.

Article  Google Scholar 

Kovshoff H, Williams S, Vrijens M, et al. The decisions regarding ADHD management (DRAMa) study: uncertainties and complexities in assessment, diagnosis and treatment, from the clinician’s point of view. Eur Child Adolesc Psychiatry. 2012;21(2):87–99. https://doi.org/10.1007/s00787-011-0235-8.

Article  PubMed  Google Scholar 

Hodgkins P, Shaw M, Coghill D, Hechtman L. Amfetamine and methylphenidate medications for attention-deficit/ hyperactivity disorder: complementary treatment options. Eur Child Adolesc Psychiatry. 2012;21:477–92. https://doi.org/10.1007/s00787-012-0286-5.

Article  PubMed  PubMed Central  Google Scholar 

Kamimura-Nishimura KI, Brinkman WB, Froehlich TE. Strategies for improving ADHD medication adherence. Curr Psychiatry. 2019;18(8):25.

Google Scholar 

Luman M, Goos V, Oosterlaan J. Instrumental learning in ADHD in a context of reward: intact learning curves and performance improvement with methylphenidate. J Abnorm Child Psychol. 2015;43(4):681–91. https://doi.org/10.1007/s10802-014-9934-1.

Article  PubMed  Google Scholar 

Froehlich TE, Epstein JN, Nick TG, Melguizo Castro MS, et al. Pharmacogenetic predictors of methylphenidate dose-response in attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2011;50(11):1129–39. https://doi.org/10.1016/j.jaac.2011.08.002.

Article  PubMed  PubMed Central  Google Scholar 

Scheres A, Oosterlaan J, Swanson J, et al. The effect of methylphenidate on three forms of response inhibition in boys with AD/HD. J Abnorm Child Psychol. 2003;31(1):105–20. https://doi.org/10.1023/a:1021729501230.

Article  PubMed  Google Scholar 

Geladé K, Bink M, Janssen TWP, et al. An RCT into the effects of neurofeedback on neurocognitive functioning compared to stimulant medication and physical activity in children with ADHD. Eur Child Adolesc Psychiatry. 2017;26(4):457–68. https://doi.org/10.1007/s00787-016-0902-x.

Article  PubMed  Google Scholar 

Reichart CG, Wals M, Hillegers M. Vertaling K-sads. Utrecht: HC Rümke Groep; 2000.

Google Scholar 

Kaufman J, Birmaher B, Brent D, et al. Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry. 1997;36(7):980–8. https://doi.org/10.1097/00004583-199707000-00021.

Article  CAS  PubMed  Google Scholar 

Oosterlaan J, Baeyens D, Scheres A, Antrop I, Roeyers H, Sergeant JA. Vragenlijst voor gedragsproblemen bij kinderen 6–16 jaar, Handleiding. Amsterdam: Harcourt Publisher; 2008.

Google Scholar 

Praktikon. https://www.bergop.info.

Swanson JM, Schuck S, Porter M, et al. Categorical and dimensional definitions and evaluations of symptoms of ADHD: history of the SNAP and the SWAN rating scales. Int J Educ Psychol Assess. 2012;10(1):51–70.

PubMed  PubMed Central  Google Scholar 

Young DJ, Levy F, Martin NC, Hay DA. Attention deficit hyperactivity disorder: a Rasch analysis of the SWAN rating scale. Child Psychiatry Hum Dev. 2009;40(4):543–59. https://doi.org/10.1007/s10578-009-0143-z.

Article  PubMed  Google Scholar 

Twisk JWR. Analysis of data from a randomized controlled trial. A practical guide. Heidelberg: Springer; 2021.

Book  Google Scholar 

Twisk JWR. Applied mixed model analysis. Cambridge: Cambridge University Press; 2019.

Book  Google Scholar 

Gray JR, Kagan J. The challenge of predicting which children with attention deficit-hyperactivity disorder will respond positively to methylphenidate. J Appl Dev Psychol. 2000;21(5):471–89.

Article  Google Scholar 

Johnston BA, Coghill D, Matthews K, Steele JD. Predicting methylphenidate response in attention deficit hyperactivity disorder: a preliminary study. J Psychopharmacol. 2015;29(1):4–30. https://doi.org/10.1177/0269881114548438.

Article  CAS  Google Scholar 

Cortese S, Newcorn JH, Coghill D. A practical, evidence-informed approach to managing stimulant-refractory attention deficit hyperactivity disorder (ADHD). CNS Drugs. 2021. https://doi.org/10.1007/s40263-021-00848-3.

Article  PubMed  Google Scholar 

Faraone SV, Newcorn JH, Cipriani A, et al. Placebo and nocebo responses in randomised, controlled trials of medications for ADHD: a systematic review and meta-analysis. Mol Psychiatry. 2022;27(1):212–9. https://doi.org/10.1038/s41380-021-01134-w.

Article  PubMed  Google Scholar 

留言 (0)

沒有登入
gif