Resource utilization and cost assessment of a proactive penicillin allergy de-labeling program for low-risk inpatients

Joint Task Force on Practice Parameters. Drug allergy: an updated practice parameter. Ann Allergy Asthma Immunol. 2010;105(4):259–73.

Article  Google Scholar 

Lee CE, Zembower TR, Fotis MA, Postelnick MJ, Greenberger PA, Peterson LR, et al. The incidence of antimicrobial allergies in hospitalized patients: implication regarding prescribing patterns and emerging bacterial resistance. Arch Intern Med. 2000;160:2819–22.

Article  CAS  PubMed  Google Scholar 

Liang EH, Chen LH, Macy E. Adverse reactions Associated with penicillins, carbapenems, monobactams, and clindamycin: a Retrospective Population-based study. J Allergy Clin Immunol Pract. 2020;8(4):1302–1313e2. Epub 2019 Dec 9. PMID: 31821919.

Article  PubMed  Google Scholar 

Sacco KA, Bates A, Brigham TJ, Imam JS, Burton MC. Clinical outcomes following inpatient penicillin allergy testing: a systematic review and meta-analysis. Allergy. 2017;72(9):1288–96. https://doi.org/10.1111/all.13168. Epub 2017 Apr 26. PMID: 28370003.

Article  CAS  PubMed  Google Scholar 

Stone CA Jr, Trubiano J, Coleman DT, Rukasin CRF, Phillips EJ. The challenge of de-labeling penicillin allergy. Allergy. 2020;75(2):273–88.

Article  CAS  PubMed  Google Scholar 

Blumenthal KG, Lu N, Zhang Y, Li Y, Walensky RP, Choi HK. Risk of meticillin resistant Staphylococcus aureus and Clostridium difficile in patients with a documented penicillin allergy: population based matched cohort study. BMJ. 2018;361:k2400.

Article  PubMed  PubMed Central  Google Scholar 

Macy E, Contreras R. Health care use and serious Infection prevalence associated with penicillin allergy in hospitalized patients: a cohort study. J Allergy Clin Immunol. 2014;133(3):790–6.

Article  PubMed  Google Scholar 

Blumenthal KG, Lu N, Zhang Y, Walensky RP, Choi HK. Recorded penicillin allergy and risk of mortality: a population-based matched cohort study. J Gen Intern Med. 2019;34:1685–7.

Article  PubMed  PubMed Central  Google Scholar 

Sousa-Pinto B, Cardoso-Fernandes A, Araujo L, Fonseca JA, Freitas A, Delgado L. Clinical and economic burden of hospitalizations with registration of penicillin allergy. Ann Allergy Asthma Immunol. 2018;120:190–4e2.

Article  PubMed  Google Scholar 

Picard M, Bégin P, Bouchard H, Cloutier J, Lacombe-Barrios J, Paradis J, et al. Treatment of patients with a history of penicillin allergy in a large tertiary-care academic hospital. J Allergy Clin Immunol Pract. 2013 May-Jun;1(3):252–7.

Li J, Shahabi-Sirjani A, Figtree M, Hoyle P, Fernando SL. Safety of direct drug provocation testing in adults with penicillin allergy and association with health and economic benefits. Ann Allergy Asthma Immunol. 2019;123:468–75.

Article  CAS  PubMed  Google Scholar 

Rimawi RH, Cook PP, Gooch M, Kabchi B, Ashraf MS, Rimawi BH, et al. The impact of penicillin skin testing on clinical practice and antimicrobial stewardship. J Hosp Med. 2013;8(6):341–5.

Article  PubMed  Google Scholar 

Jones BM, Bland CM. Penicillin skin testing as an antimicrobial stewardship initiative. Am J Health-Syst Pharm. 2017;74(4):232–7.

Article  CAS  PubMed  Google Scholar 

King EA, Challa S, Curtin P, Bielory L. Penicillin skin testing in hospitalized patients with β-lactam allergies: effect on antibiotic selection and cost. Ann Allergy Asthma Immunol. 2016;117(1):67–71.

Article  CAS  PubMed  Google Scholar 

​​Chen JR, Tarver SA, Alvarez KS, Wei W, Khan DA. Improving aztreonam stewardship and cost through a penicillin allergy testing clinical guideline. Open Forum Infect Dis. 2018;5(6):ofy106.

Article  PubMed  PubMed Central  Google Scholar 

Dodek P, Phillips P. Questionable history of immediate-type hypersensitivity to penicillin in staphylococcal endocarditis: treatment based on skin-test results versus empirical alternative treatment–a decision analysis. Clin Infect Dis. 1999;29(5):1251–6.

Article  CAS  PubMed  Google Scholar 

Fan B, Udeh B, Quinn N, Bernard SL, Grobmyer SR, Valente SA. Delabeling Penicillin Allergy in Breast Surgery Patients: A Cost Analysis. Am Surg. 2020;86(2):e75-e78. PMID: 32106918.

Mill C, Primeau MN, Medoff E, Lejtenyl C, O’Keefe A, Netchiporouk E, et al. Assessing the diagnostic properties of a graded oral provocation challenge for the diagnosis of immediate and non immediate reactions to Amoxicillin in children. JAMA Pediatr. 2016;170:1–8.

Article  Google Scholar 

Trubiano JA, Smibert O, Douglas A, Devchand M, Lambros B, Holmes NE, et al. The safety and efficacy of an oral penicillin challenge program in cancer patients: a multicenter pilot study. Open Forum Infect Dis. 2018;5:ofy306.

Article  PubMed  PubMed Central  Google Scholar 

Iammatteo M, Alvarez Arango S, Ferastraoaru D, Akbar N, Lee AY, Cohen HW et al. Safety and outcomes of oral graded challenges to Amoxicillin without prior skin testing. J Allergy Clin Immunol.

Banks TA, Tucker M, Macy E. Evaluating penicillin allergies without skin testing. Curr Allergy Asthma Rep. 2019;19:27.

Article  PubMed  Google Scholar 

Ramsey A, Mustafa SS, Holly AM, Staicu ML. Direct challenges to penicillin-based antibiotics in the Inpatient setting. J Allergy Clin Immunol Pract. 2020 Jul-Aug;8(7):2294–301.

Mustafa SS, Conn K, Ramsey A. Comparing direct challenge to penicillin skin testing for the outpatient evaluation of penicillin allergy: a Randomized Controlled Trial. J Allergy Clin Immunol Pract 2019 Sep-Oct;7(7):2163–70.

Sousa-Pinto B, Blumenthal KG, Macy E, Pereira AM, Azevedo LF, Delgado L, et al. Penicillin Allergy Testing is Cost-Saving: an economic evaluation study. Clin Infect Dis. 2021;72(6):924–38.

Article  PubMed  Google Scholar 

Sobrino-García M, Muñoz-Bellido FJ, Moreno E, Macías E, Gracia-Bara MT, Laffond E, et al. A comprehensive prospective study of the costs Associated with evaluation of ß-Lactam allergy. J Investig Allergol Clin Immunol. 2021;31(1):52–7.

Article  PubMed  Google Scholar 

Sousa-Pinto B, Blumenthal KG, Macy E, Bavbek S, Benić MS, Alves-Correia M, et al. Diagnostic testing for penicillin allergy: a survey of practices and cost perceptions. Allergy. 2020;75(2):436–41.

Article  PubMed  Google Scholar 

Chua KYL, Vogrin S, Bury S, Douglas A, Holmes NE, Tan N, et al. The penicillin Allergy Delabeling Program: a Multicenter Whole-of-Hospital Health Services Intervention and comparative effectiveness study. Clin Infect Dis. 2021;73(3):487–96.

Article  CAS  PubMed  Google Scholar 

Blumenthal KG, Li Y, Banerji A, Yun BJ, Long AA, Walensky RP. The cost of penicillin allergy evaluation. J Allergy Clin Immunol Pract 2018 May-Jun;6(3):1019–1027e2.

Ferré-Ybarz L, Salinas Argente R, Gómez Galán C, Duocastella Selvas P, Nevot Falcó S. Analysis of profitability in the diagnosis of allergy to beta-lactam antibiotics. Allergol Immunopathol (Madr). 2015 Jul-Aug;43(4):369–75. https://doi.org/10.1016/j.aller.2014.04.009. Epub 2014 Jul 31. PMID: 25087091.

Shenoy ES, Macy E, Rowe T, Blumenthal KG. Evaluation and management of penicillin allergy: a review. JAMA. 2019;321(2):188–99.

Article  PubMed  Google Scholar 

Trend analysis - Explore the market - Job Bank. (2023). Retrieved 20 February 2023, from https://www.jobbank.gc.ca/trend-analysis.

Kaplan RS, Anderson SR. Time-driven activity-based costing: a simpler and more powerful path to higher profits. Boston, MA: Harvard Business School Publishing; 2007.

Google Scholar 

Kaplan RS, Porter ME. How to solve the cost crisis in health care. Harv Bus Rev. 2011;89(9):47–64.

Google Scholar 

Lopetegui M, Yen PY, Lai A, Jeffries J, Embi P, Payne P. Time motion studies in healthcare: what are we talking about? J Biomed Inform. 2014;49:292–9. https://doi.org/10.1016/j.jbi.2014.02.017. Epub 2014 Mar 7. PMID: 24607863; PMCID: PMC4058370.

Article  PubMed  Google Scholar 

Inflation Calculator. (2023). Retrieved 28 February 2023, from https://www.bankofcanada.ca/rates/related/inflation-calculator/.

留言 (0)

沒有登入
gif