Apam-Castillejos DJ, Tendilla-Beltrán H, Vázquez-Roque RA, Vázquez-Hernández AJ, Fuentes-Medel E, García-Dolores F, Díaz A, Flores G (2022) Second-generation antipsychotic olanzapine attenuates behavioral and prefrontal cortex synaptic plasticity deficits in a neurodevelopmental schizophrenia-related rat model. J Chem Neuroanat 125:102166

Article  CAS  PubMed  Google Scholar 

Bernstein HG, Krell D, Braunewell KH, Baumann B, Gundelfinger ED, Diekmann S, Danos P, Bogerts B (2001) Increased number of nitric oxide synthase immunoreactive Purkinje cells and dentate nucleus neurons in schizophrenia. J Neurocytol 30:661–670

Article  CAS  PubMed  Google Scholar 

Bishara D, Olofinjana O, Sparshatt A, Kapur S, Taylor D, Patel MX (2013) Olanzapine: a systematic review and meta-regression of the relationships between dose, plasma concentration, receptor occupancy, and response. J Clin Psychopharmacol 33:329–335

Article  CAS  PubMed  Google Scholar 

Brandt L, Montag C, Bermpohl F, Finck A, Wieacker E, Heinz A, Gutwinski S (2022) The effect of second-generation antipsychotic withdrawal on the occurrence of vacuous chewing movements in animal models: a review. Behav Brain Res 418:113637

Article  CAS  PubMed  Google Scholar 

Carreño-Gutiérrez H, O’Leary A, Freudenberg F, Fedele G, Wilkinson R, Markham E, van Eeden F, Reif A, Norton WHJ (2020) Nitric oxide interacts with monoamine oxidase to modulate aggression and anxiety-like behaviour. Eur Neuropsychopharmacol 30:30–43

Article  PubMed  Google Scholar 

Chen M, Pritchard C, Fortune D, Kodi P, Grados M (2020) Hydrogen sulfide: a target to modulate oxidative stress and neuroplasticity for the treatment of pathological anxiety. Expert Rev Neurother 20:109–121

Article  PubMed  Google Scholar 

Das I, Khan NS, Puri BK, Hirsch SR (1996) Elevated endogenous nitric oxide synthase inhibitor in schizophrenic plasma may reflect abnormalities in brain nitric oxide production. Neurosci Lett 215:209–211

Article  CAS  PubMed  Google Scholar 

Dhir A, Kulkarni SK (2007) Involvement of nitric oxide (NO) signaling pathway in the antidepressant action of bupropion, a dopamine reuptake inhibitor. Eur J Pharmacol 568:177–185

Article  CAS  PubMed  Google Scholar 

Donald JA (2016) Subchapter 103B carbon monoxide. In: Takei WY, Ando H, Tsutsui K (eds) Handbook of hormones. Academic Press, San Diego

Google Scholar 

Duggan L, Fenton M, Rathbone J, Dardennes R, El-Dosoky A, Indran S (2005) Olanzapine for schizophrenia. Cochrane Database Syst Rev 18:CD001359

Google Scholar 

Eshaghi E, Sadigh-Eteghad S, Mohaddes G, Rasta SH (2019) Transcranial photobiomodulation prevents anxiety and depression via changing serotonin and nitric oxide levels in brain of depression model mice: a study of three different doses of 810 nm laser. Lasers Surg Med 51:634–642

Article  PubMed  Google Scholar 

Karson CN, Griffin WS, Mrak RE, Husain M, Dawson TM, Snyder SH, Moore NC, Sturner WQ (1996) Nitric oxide synthase (NOS) in schizophrenia: increases in cerebellar vermis. Mol Chem Neuropathol 27:275–284

Article  CAS  PubMed  Google Scholar 

Khalilzadeh M, Hassanzadeh F, Aghamiri H, Dehpour AR, Shafaroodi H (2020) Aripiprazole prevents from development of vincristine-induced neuropathic nociception by limiting neural NOS overexpression and NF-kB hyperactivation. Cancer Chemother Pharmacol 86:393–404

Article  CAS  PubMed  Google Scholar 

Krzystanek M, Pałasz A (2019) NMDA receptor model of antipsychotic drug-induced hypofrontality. Int J Mol Sci 20:1442

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lau YS, Petroske E, Meredith GE, Wang JQ (2003) Elevated neuronal nitric oxide synthase expression in chronic haloperidol-treated rats. Neuropharmacology 45:986–994

Article  CAS  PubMed  Google Scholar 

Lourenço CF, Ferreira NR, Santos RM, Lukacova N, Barbosa RM, Laranjinha J (2014) The pattern of glutamate-induced nitric oxide dynamics in vivo and its correlation with nNOS expression in rat hippocampus, cerebral cortex and striatum. Brain Res 1554:1–11

Article  PubMed  Google Scholar 

Nel A, Harvey BH (2003) Haloperidol-induced dyskinesia is associated with striatal NO synthase suppression: reversal with olanzapine. Behav Pharmacol 14:251–255

Article  CAS  PubMed  Google Scholar 

Oh SJ, Fan X (2020) Current understanding on the role of nitric oxide and therapeutic potential of NO supplementation in schizophrenia. Schizophrenia Res 222:23–30

Article  Google Scholar 

Olijslagers JE, Werkman TR, McCreary AC, Kruse CG, Wadman WJ (2006) Modulation of midbrain dopamine neurotransmission by serotonin, a versatile interaction between neurotransmitters and significance for antipsychotic drug action. Curr Neuropharmacol 4:59–68

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pałasz A, Menezes IC, Worthington JJ (2021) The role of brain gaseous neurotransmitters in anxiety. Pharmacol Rep 73:357–371

Article  PubMed  PubMed Central  Google Scholar 

Paxinos G, Watson C (2007) The rat brain in stereotaxic coordinates. Elsevier

Google Scholar 

Picón-Pagès P, Garcia-Buendia J, Muñoz FJ (2019) Functions and dysfunctions of nitric oxide in brain. Biochim Biophys Acta (BBA) 1865:1949–1967

Article  Google Scholar 

Pigott BM, Garthwaite J (2016) Nitric oxide is required for L-type Ca (2+) channel-dependent long-term potentiation in the hippocampus. Front Synaptic Neurosci 8:17

Article  PubMed  PubMed Central  Google Scholar 

Reif A, Jacob CP, Rujescu D, Herterich S, Lang S, Gutknecht L, Baehne CG, Strobel A, Freitag CM, Giegling I, Romanos M, Hartmann A, Rösler M, Renner TJ, Fallgatter AJ, Retz W, Ehlis AC, Lesch KP (2009) Influence of functional variant of neuronal nitric oxide synthase on impulsive behaviors in humans. Arch Gen Psychiatry 66:41–50

Article  CAS  PubMed  Google Scholar 

Sommer O, Aug RL, Schmidt AJ, Heiser P, Schulz E, Vedder H, Clement HW (2018) Hydrogen sulfide affects radical formation in the hippocampus of LPS treated rats and the effect of antipsychotics on hydrogen sulfide forming enzymes in human cell lines. Front Psychiatry 9:501

Article  PubMed  PubMed Central  Google Scholar 

Tarazi FI, Zhang K, Baldessarini RJ (2002) Long-term effects of newer antipsychotic drugs on neuronal nitric oxide synthase in rat brain. Nitric Oxide 7:297–300

Article  CAS  PubMed  Google Scholar 

Tripathi MK, Kartawy M, Amal H (2020) The role of nitric oxide in brain disorders: autism spectrum disorder and other psychiatric, neurological, and neurodegenerative disorders. Redox Biol 34:101567

Article  CAS  PubMed  PubMed Central  Google Scholar 

TuralHesapcioglu S, Ceylan MF, Kasak M, Sen CP (2020) Olanzapine, risperidone, and aripiprazole use in children and adolescents with autism spectrum disorders. Res Aut Spectr Disord 72:101520

Article  Google Scholar 

Wegener G, Volke V (2010) Nitric oxide synthase inhibitors as antidepressants. Pharmaceuticals (basel) 3:273–299. https://doi.org/10.3390/ph3010273

Article  CAS  PubMed  Google Scholar 

Yakovleva O, Bogatova K, Mukhtarova R, Yakovlev A, Shakhmatova V, Gerasimova E, Ziyatdinova G, Hermann A, Sitdikova G (2020) Hydrogen sulfide alleviates anxiety, motor, and cognitive dysfunctions in rats with maternal hyperhomocysteinemia via mitigation of oxidative stress. Biomolecules 10:E995

Article  Google Scholar 

Young SL, Taylor M, Lawrie SM (2015) “First do no harm.” A systematic review of the prevalence and management of antipsychotic adverse effects. J Psychopharmacol 29:353–362. https://doi.org/10.1177/0269881114562090

Article  CAS  PubMed  Google Scholar 

Zhang XR, Wang YX, Zhang ZJ, Li L, Reynolds GP (2012) The effect of chronic antipsychotic drug on hypothalamic expression of neural nitric oxide synthase and dopamine D2 receptor in the male rat. PLoS ONE 7:33247

Article  Google Scholar