Bingel U, Lorenz J, Schoell E, Weiller C, Büchel C (2006) Mechanisms of placebo analgesia: rACC recruitment of a subcortical antinociceptive network. Pain 120(1–2):8–15. https://doi.org/10.1016/j.pain.2005.08.027

Article  CAS  PubMed  Google Scholar 

Bonin EAC, Lejeune N, Szymkowicz E, Bonhomme V, Martial C, Gosseries O, Laureys S, Thibaut A (2023) Assessment and management of pain/nociception in patients with disorders of consciousness or locked-in syndrome: a narrative review. Front Syst Neurosci 17:1112206. https://doi.org/10.3389/fnsys.2023.1112206

Article  PubMed  PubMed Central  Google Scholar 

Bray NL, Pimentel H, Melsted P, Pachter L (2016) Near-optimal probabilistic RNA-seq quantification. Nat Biotechnol 34(5):525–527. https://doi.org/10.1038/nbt.3519

Article  CAS  PubMed  Google Scholar 

Calvo M, Dawes JM, Bennett DL (2012) The role of the immune system in the generation of neuropathic pain. Lancet Neurol 11(7):629–642. https://doi.org/10.1016/s1474-4422(12)70134-5

Article  CAS  PubMed  Google Scholar 

Chamaa F, Chebaro M, Safieh-Garabedian B, Saadeh R, Jabbur SJ, Saadé NE (2016) Transcriptional expression of inflammatory mediators in various somatosensory relay centers in the brain of rat models of peripheral mononeuropathy and local inflammation. J Neuroimmunol 297:81–91. https://doi.org/10.1016/j.jneuroim.2016.05.005

Article  CAS  PubMed  Google Scholar 

Chen S, Zhou Y, Chen Y, Gu J (2018) Fastp: an ultra-fast all-in-one FASTQ preprocessor. Bioinformatics 34(17):i884–i890. https://doi.org/10.1093/bioinformatics/bty560

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cui X, Qin B, Xia C, Li H, Li Z, Li Z, Nasir A, Bai Q (2023) Transcriptome-wide analysis of trigeminal ganglion and subnucleus caudalis in a mouse model of chronic constriction injury-induced trigeminal neuralgia. Front Pharmacol 14:1230633. https://doi.org/10.3389/fphar.2023.1230633

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dantzer R (2004) Cytokine-induced sickness behaviour: a neuroimmune response to activation of innate immunity. Eur J Pharmacol 500(1–3):399–411. https://doi.org/10.1016/j.ejphar.2004.07.040

Article  CAS  PubMed  Google Scholar 

Dong T, Si H, Li Z, Bai Q, Tao F (2022) Transcriptomic analysis of trigeminal ganglion and spinal trigeminal nucleus Caudalis in mice with inflammatory Temporomandibular Joint Pain. J Pain Res 15:1487–1502. https://doi.org/10.2147/jpr.S364887

Article  PubMed  PubMed Central  Google Scholar 

Elberg G, Liraz-Zaltsman S, Reichert F, Matozaki T, Tal M, Rotshenker S (2019) Deletion of SIRPα (signal regulatory protein-α) promotes phagocytic clearance of myelin debris in Wallerian degeneration, axon regeneration, and recovery from nerve injury. J Neuroinflammation 16(1):277. https://doi.org/10.1186/s12974-019-1679-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Faulkner JR, Herrmann JE, Woo MJ, Tansey KE, Doan NB, Sofroniew MV (2004) Reactive astrocytes protect tissue and preserve function after spinal cord injury. J Neurosci 24(9):2143–2155. https://doi.org/10.1523/jneurosci.3547-03.2004

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grace PM, Tawfik VL, Svensson CI, Burton MD, Loggia ML, Hutchinson MR (2021) The Neuroimmunology of Chronic Pain: from rodents to humans. J Neurosci 41(5):855–865. https://doi.org/10.1523/jneurosci.1650-20.2020

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gybels J, Kupers R (1990) Deep brain stimulation in the treatment of chronic pain in man: where and why? Neurophysiol Clin 20(5):389–398. https://doi.org/10.1016/s0987-7053(05)80206-0

Article  CAS  PubMed  Google Scholar 

Halassa MM, Fellin T, Haydon PG (2007) The tripartite synapse: roles for gliotransmission in health and disease. Trends Mol Med 13(2):54–63. https://doi.org/10.1016/j.molmed.2006.12.005

Article  CAS  PubMed  Google Scholar 

Ji RR, Chamessian A, Zhang YQ (2016) Pain regulation by non-neuronal cells and inflammation. Science 354(6312):572–577. https://doi.org/10.1126/science.aaf8924

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khasabov SG, Simone DA (2013) Loss of neurons in rostral ventromedial medulla that express neurokinin-1 receptors decreases the development of hyperalgesia. Neuroscience 250:151–165. https://doi.org/10.1016/j.neuroscience.2013.06.057

Article  CAS  PubMed  Google Scholar 

Konishi H, Koizumi S, Kiyama H (2022) Phagocytic astrocytes: emerging from the shadows of microglia. Glia 70(6):1009–1026. https://doi.org/10.1002/glia.24145

Article  PubMed  PubMed Central  Google Scholar 

Li H, Li X, Feng Y, Gao F, Kong Y, Hu L (2020) Deficits in ascending and descending pain modulation pathways in patients with postherpetic neuralgia. NeuroImage 221:117186. https://doi.org/10.1016/j.neuroimage.2020.117186

Article  PubMed  Google Scholar 

Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, Bennett ML, Münch AE, Chung WS, Peterson TC, Wilton DK, Frouin A, Napier BA, Panicker N, Kumar M, Buckwalter MS, Rowitch DH, Dawson VL, Dawson TM, Stevens B, Barres BA (2017) Neurotoxic reactive astrocytes are induced by activated microglia. Nature 541(7638):481–487. https://doi.org/10.1038/nature21029

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu H, Leak RK, Hu X (2016) Neurotransmitter receptors on microglia. Stroke Vasc Neurol 1(2):52–58. https://doi.org/10.1136/svn-2016-000012

Article  PubMed  PubMed Central  Google Scholar 

Liu Q, Mai L, Yang S, Jia S, Chu Y, He H, Fan W, Huang F (2022) Transcriptional alterations of mouse trigeminal ganglion neurons following orofacial inflammation revealed by single-cell analysis. Front Cell Neurosci 16:885569. https://doi.org/10.3389/fncel.2022.885569

Article  CAS  PubMed  PubMed Central  Google Scholar 

McMahon SB, La Russa F, Bennett DL (2015) Crosstalk between the nociceptive and immune systems in host defence and disease. Nat Rev Neurosci 16(7):389–402. https://doi.org/10.1038/nrn3946

Article  CAS  PubMed  Google Scholar 

Mercer Lindsay N, Chen C, Gilam G, Mackey S, Scherrer G (2021) Brain circuits for pain and its treatment. Sci Transl Med 13(619):eabj7360. https://doi.org/10.1126/scitranslmed.abj7360

Article  PubMed  Google Scholar 

Milligan ED, Watkins LR (2009) Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci 10(1):23–36. https://doi.org/10.1038/nrn2533

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miyamoto A, Wake H, Ishikawa AW, Eto K, Shibata K, Murakoshi H, Koizumi S, Moorhouse AJ, Yoshimura Y, Nabekura J (2016) Microglia contact induces synapse formation in developing somatosensory cortex. Nat Commun 7:12540. https://doi.org/10.1038/ncomms12540

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moisset X, Bouhassira D (2007) Brain imaging of neuropathic pain. Neuroimage 37 Suppl 1S80–88. https://doi.org/10.1016/j.neuroimage.2007.03.054

Nicotra L, Loram LC, Watkins LR, Hutchinson MR (2012) Toll-like receptors in chronic pain. Exp Neurol 234(2):316–329. https://doi.org/10.1016/j.expneurol.2011.09.038

Article  CAS  PubMed  Google Scholar 

Pertea M, Kim D, Pertea GM, Leek JT, Salzberg SL (2016) Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown. Nat Protoc 11(9):1650–1667. https://doi.org/10.1038/nprot.2016.095

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pinho-Ribeiro FA, Verri WA Jr., Chiu IM (2017) Nociceptor sensory Neuron-Immune interactions in Pain and inflammation. Trends Immunol 38(1):5–19. https://doi.org/10.1016/j.it.2016.10.001

Article  CAS  PubMed  Google Scholar 

Wager TD, Atlas LY, Lindquist MA, Roy M, Woo CW, Kross E (2013) An fMRI-based neurologic signature of physical pain. N Engl J Med 368(15):1388–1397. https://doi.org/10.1056/NEJMoa1204471

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang LH, Ding WQ, Sun YG (2022) Spinal ascending pathways for somatosensory information processing. Trends Neurosci 45(8):594–607. https://doi.org/10.1016/j.tins.2022.05.005

Article  CAS  PubMed  Google Scholar 

Xu A, Larsen B, Baller EB, Scott JC, Sharma V, Adebimpe A, Basbaum AI, Dworkin RH, Edwards RR, Woolf CJ, Eickhoff SB, Eickhoff CR, Satterthwaite TD (2020) Convergent neural representations of experimentally-induced acute pain in healthy volunteers: a large-scale fMRI meta-analysis. Neurosci Biobehav Rev 112:300–323. https://doi.org/10.1016/j.neubiorev.2020.01.004

Article  PubMed  PubMed Central  Google Scholar