Uhler MD, Carmichael DF, Lee DC, Chrivia JC, Krebs EG, McKnight GS. Isolation of cDNA clones coding for the catalytic subunit of mouse cAMP-dependent protein kinase. Proc Natl Acad Sci USA. 1986;83:1300–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Caldwell JL, Lee IJ, Ngo L, Wang L, Bahriz S, Xu B, et al. Whole-heart multiparametric optical imaging reveals sex-dependent heterogeneity in cAMP signaling and repolarization kinetics. Sci Adv. 2023;9:eadd5799.

Article  PubMed  PubMed Central  Google Scholar 

Martinez JM, Shen A, Xu B, Jovanovic A, de Chabot J, Zhang J, et al. Arrestin-dependent nuclear export of phosphodiesterase 4D promotes GPCR-induced nuclear cAMP signaling required for learning and memory. Sci Signal. 2023;16:eade3380.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roy D, Balasubramanian S, Krishnamurthy PT, Sola P, Rymbai E. Phosphodiesterase-4 inhibition in Parkinson’s disease: molecular insights and therapeutic potential. Cell Mol Neurobiol. 2023;43:2713–41.

Article  CAS  PubMed  Google Scholar 

Fuentes-Pananá EM, Peng R, Brewer G, Tan J, Ling PD. Regulation of the Epstein–Barr virus C promoter by AUF1 and the cyclic AMP/protein kinase A signaling pathway. J Virol. 2000;74:8166–75.

Article  PubMed  PubMed Central  Google Scholar 

Moar P, Sushmita K, Kateriya S, Tandon R. Transcriptional profiling indicates cAMP-driven reversal of HIV latency in monocytes occurs via transcription factor SP-1. Virology. 2020;542:40–53.

Article  CAS  PubMed  Google Scholar 

Luo Z, Li M, Li TW, Lv Z, Ye Z, Cisneros WJ, et al. Differential expression of CREM/ICER isoforms is associated with the spontaneous control of HIV infection. mBio. 2022;13:e0197921.

Article  PubMed  Google Scholar 

Xu K, Cooney KA, Shin EY, Wang L, Deppen JN, Ginn SC, et al. Adenosine from a biologic source regulates neutrophil extracellular traps (NETs). J Leukoc Biol. 2019;105:1225–34.

Article  CAS  PubMed  Google Scholar 

Ravani A, Vincenzi F, Bortoluzzi A, Padovan M, Pasquini S, Gessi S, et al. Role and function of A2A and A3 adenosine receptors in patients with ankylosing spondylitis, psoriatic arthritis and rheumatoid arthritis. Int J Mol Sci. 2017;18:697.

Article  PubMed  PubMed Central  Google Scholar 

Zhang L, Yang N, Wang S, Huang B, Li F, Tan H, et al. Adenosine 2A receptor is protective against renal injury in MRL/lpr mice. Lupus. 2011;20:667–77.

Article  CAS  PubMed  Google Scholar 

Chung JH, Choi HJ, Kang YJ, Kim YS, Lee SY, Kwon RJ, et al. MHY4571, a novel diarylcyclohexanone derivative, exerts anti-cancer activity by regulating the PKA-cAMP-response element-binding protein pathway in squamous cell lung cancer. Exp Hematol Oncol. 2022;11:68.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Knighton DR, Zheng JH, Ten Eyck LF, Ashford VA, Xuong NH, Taylor SS, et al. Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science. 1991;253:407–14.

Article  CAS  PubMed  Google Scholar 

Stolfa I, Page C. Phosphodiesterase inhibitors and lung diseases. Adv Pharmacol. 2023;98:55–81.

Article  PubMed  Google Scholar 

Tsuji G, Yamamura K, Kawamura K, Kido-Nakahara M, Ito T, Nakahara T. Novel therapeutic targets for the treatment of atopic dermatitis. Biomedicines. 2023;11:1303.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sadeghi MA, Nassireslami E, Yousefi Zoshk M, Hosseini Y, Abbasian K, Chamanara M. Phosphodiesterase inhibitors in psychiatric disorders. Psychopharmacology. 2023;240:1201–19.

Article  CAS  PubMed  Google Scholar 

Jeong MH, Urquhart G, Lewis C, Chi Z, Jewell JL. Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth. JCI Insight. 2023;8:e158098.

Article  PubMed  PubMed Central  Google Scholar 

Lee A, Lebedyeva I, Zhi W, Senthil V, Cheema H, Brands MW, et al. A non-systemic phosphodiesterase-5 inhibitor suppresses colon proliferation in mice. Int J Mol Sci. 2023;24:9397.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Godbole A, Lyga S, Lohse MJ, Calebiro D. Internalized TSH receptors en route to the TGN induce local G(s)-protein signaling and gene transcription. Nat Commun. 2017;8:443.

Article  PubMed  PubMed Central  Google Scholar 

Arkhipov A, Khuzakhmetova V, Petrov AM, Bukharaeva EA. Catecholamine-dependent hyperpolarization of the junctional membrane via β2-adrenoreceptor/G(i)-protein/α2-Na-K-ATPase pathway. Brain Res. 2022;1795:148072.

Article  CAS  PubMed  Google Scholar 

Tang G, Guo Y, Zhang L, Wang T, Li R, Yang J, et al. 5-HT(1B) receptors in the basolateral amygdaloid nucleus regulate anxiety-like behaviors through AC-PKA signal pathway in a rat model of Parkinson’s disease. Behav Brain Res. 2023;449:114488.

Article  CAS  PubMed  Google Scholar 

Ostrom KF, LaVigne JE, Brust TF, Seifert R, Dessauer CW, Watts VJ, et al. Physiological roles of mammalian transmembrane adenylyl cyclase isoforms. Physiol Rev. 2022;102:815–57.

Article  CAS  PubMed  Google Scholar 

Pizzoni A, Zhang X, Naim N, Altschuler DL. Soluble cyclase-mediated nuclear cAMP synthesis is sufficient for cell proliferation. Proc Natl Acad Sci USA. 2023;120:e2208749120.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tenner B, Getz M, Ross B, Ohadi D, Bohrer CH, Greenwald E, et al. Spatially compartmentalized phase regulation of a Ca(2+)-cAMP-PKA oscillatory circuit. Elife. 2020;9:e55013.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Piggott LA, Bauman AL, Scott JD, Dessauer CW. The A-kinase anchoring protein Yotiao binds and regulates adenylyl cyclase in brain. Proc Natl Acad Sci USA. 2008;105:13835–40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maurice DH, Ke H, Ahmad F, Wang Y, Chung J, Manganiello VC. Advances in targeting cyclic nucleotide phosphodiesterases. Nat Rev Drug Discov. 2014;13:290–314.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Beavo JA. Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol Rev. 1995;75:725–48.

Article  CAS  PubMed  Google Scholar 

Andrew TB, Joseph AB. Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use. Pharmacol Rev. 2006;58:488.

Article  Google Scholar 

Paes D, Schepers M, Rombaut B, van den Hove D, Vanmierlo T, Prickaerts J. The molecular biology of phosphodiesterase 4 enzymes as pharmacological targets: an interplay of isoforms, conformational states, and inhibitors. Pharmacol Rev. 2021;73:1016–49.

Article  CAS  PubMed  Google Scholar 

Sassi Y, Ahles A, Truong DJ, Baqi Y, Lee SY, Husse B, et al. Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation. J Clin Invest. 2014;124:5385–97.

Article  PubMed  PubMed Central  Google Scholar 

Jackson EK, Raghvendra DK. The extracellular cyclic AMP-adenosine pathway in renal physiology. Annu Rev Physiol. 2004;66:571–99.

Article  CAS  PubMed  Google Scholar 

Giron MC, Bin A, Brun P, Etteri S, Bolego C, Florio C, et al. Cyclic AMP in rat ileum: evidence for the presence of an extracellular cyclic AMP-adenosine pathway. Gastroenterology. 2008;134:1116–26.

Article  CAS  PubMed  Google Scholar 

Brzostowski JA, Sawai S, Rozov O, Liao XH, Imoto D, Parent CA, et al. Phosphorylation of chemoattractant receptors regulates chemotaxis, actin reorganization and signal relay. J Cell Sci. 2013;126:4614–26.

CAS  PubMed  PubMed Central  Google Scholar 

Yang H, Li G, Wu JJ, Wang L, Uhler M, Simeone DM. Protein kinase A modulates transforming growth factor-β signaling through a direct interaction with Smad4 protein. J Biol Chem. 2013;288:8737–49.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oerlecke I, Bauer E, Dittmer A, Leyh B, Dittmer J. Cyclic AMP enhances TGFβ responses of breast cancer cells by upregulating TGFβ receptor I expression. PLOS ONE. 2013;8:e54261.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang H, Kong Q, Wang J, Jiang Y, Hua H. Complex roles of cAMP-PKA-CREB signaling in cancer. Exp Hematol Oncol. 2020;9:32.

Article  CAS  PubMed