Stratton MR, Campbell PJ, Futreal PA. The cancer genome. Nature. 2009;458:719–24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stratton MR. Exploring the genomes of cancer cells: progress and promise. Science (80-). 2011;331:1553–8.

Article  CAS  Google Scholar 

Martincorena I, Campbell PJ. Somatic mutation in cancer and normal cells. Science (80-). 2015;349:1483–9.

Article  CAS  Google Scholar 

Blokzijl F, de Ligt J, Jager M, Sasselli V, Roerink S, Sasaki N, et al. Tissue-specific mutation accumulation in human adult stem cells during life. Nature. 2016;538:260–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martincorena I, Fowler JC, Wabik A, Lawson ARJ, Abascal F, Hall MWJ, et al. Somatic mutant clones colonize the human esophagus with age. Science. 2018;362:911–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martincorena I, Roshan A, Gerstung M, Ellis P, Van Loo P, McLaren S, et al. Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin. Science. 2015;348:880–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yokoyama A, Kakiuchi N, Yoshizato T, Nannya Y, Suzuki H, Takeuchi Y, et al. Age-related remodelling of oesophageal epithelia by mutated cancer drivers. Nature. 2019;565:312–7.

Article  CAS  PubMed  Google Scholar 

Morata G, Ripoll P. Minutes: mutants of Drosophila autonomously affecting cell division rate. Dev Biol. 1975;42:211–21.

Article  CAS  PubMed  Google Scholar 

Moreno E, Basler K, Morata G. Cells compete for Decapentaplegic survival factor to prevent apoptosis in Drosophila wing development. Nature. 2002;416:755–9.

Article  CAS  PubMed  Google Scholar 

Hariharan IK, Bilder D. Regulation of imaginal disc growth by tumor-suppressor genes in Drosophila. Annu Rev Genet. 2006;40:335–61.

Article  CAS  PubMed  Google Scholar 

Igaki T, Pagliarini RA, Xu T. Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila. Curr Biol. 2006;16:1139–46.

Article  CAS  PubMed  Google Scholar 

Brumby AM. scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. EMBO J. 2003;22:5769–79.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Igaki T, Pastor-Pareja JC, Aonuma H, Miura M, Xu T. Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila. Dev Cell. 2009;16:458–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tamori Y, Bialucha CU, Tian A-G, Kajita M, Huang Y-C, Norman M, et al. Involvement of Lgl and Mahjong/VprBP in cell competition. PLoS Biol. 2010;8:e1000422.

Article  PubMed  PubMed Central  Google Scholar 

Menéndez J, Pérez-Garijo A, Calleja M, Morata G. A tumor-suppressing mechanism in Drosophila involving cell competition and the Hippo pathway. Proc Natl Acad Sci USA. 2010;107:14651–6.

Article  PubMed  PubMed Central  Google Scholar 

Ballesteros-Arias L, Saavedra V, Morata G. Cell competition may function either as tumour-suppressing or as tumour-stimulating factor in Drosophila. Oncogene. 2014;33:4377–84.

Article  CAS  PubMed  Google Scholar 

Thompson BJ, Mathieu J, Sung H-H, Loeser E, Rørth P, Cohen SM. Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila. Dev Cell. 2005;9:711–20.

Article  CAS  PubMed  Google Scholar 

Moberg KH, Schelble S, Burdick SK, Hariharan IK. Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth. Dev Cell. 2005;9:699–710.

Article  CAS  PubMed  Google Scholar 

Lu H, Bilder D. Endocytic control of epithelial polarity and proliferation in Drosophila. Nat Cell Biol. 2005;7:1232–9.

Article  PubMed  Google Scholar 

Moreno E, Basler K. dMyc transforms cells into super-competitors. Cell. 2004;117:117–29.

Article  CAS  PubMed  Google Scholar 

de la Cova C, Abril M, Bellosta P, Gallant P, Johnston LA. Drosophila Myc regulates organ size by inducing cell competition. Cell. 2004;117:107–16.

Article  PubMed  Google Scholar 

Kim W, Jain R. Picking winners and losers: cell competition in tissue development and homeostasis. Trends Genet. 2020;36:490–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baker NE. Emerging mechanisms of cell competition. Nat Rev Genet. 2020;21:683–97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parker TM, Gupta K, Palma AM, Yekelchyk M, Fisher PB, Grossman SR et al. Cell competition in intratumoral and tumor microenvironment interactions. EMBO J https://doi.org/10.15252/embj.2020107271 (2021).

Vishwakarma M, Piddini E. Outcompeting cancer. Nat Rev Cancer. 2020;20:187–98.

Article  CAS  PubMed  Google Scholar 

Lee C-H, Kiparaki M, Blanco J, Folgado V, Ji Z, Kumar A, et al. A regulatory response to ribosomal protein mutations controls translation, growth, and cell competition. Dev Cell. 2018;46:456–469.e4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nagata R, Nakamura M, Sanaki Y, Igaki T. Cell competition is driven by autophagy. Dev Cell. 2019;51:99–112.e4.

Article  CAS  PubMed  Google Scholar 

Iritani BM, Eisenman RN. c-Myc enhances protein synthesis and cell size during B lymphocyte development. Proc Natl Acad Sci USA. 1999;96:13180–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee C-H, Rimesso G, Reynolds DM, Cai J, Baker NE. Whole-genome sequencing and iPLEX MassARRAY genotyping map an EMS-induced mutation affecting cell competition in Drosophila melanogaster. G3 Genes Genomes Genet. 2016;6:3207–17.

Article  Google Scholar 

Akdemir F, Christich A, Sogame N, Chapo J, Abrams JM. p53 directs focused genomic responses in Drosophila. Oncogene. 2007;26:5184–93.

Article  CAS  PubMed  Google Scholar 

Tsurui-Nishimura N, Nguyen TQ, Katsuyama T, Minami T, Furuhashi H, Oshima Y, et al. Ectopic antenna induction by overexpression of CG17836/Xrp1 encoding an AT-hook DNA binding motif protein in Drosophila. Biosci Biotechnol Biochem. 2013;77:339–44.

Article  CAS  PubMed  Google Scholar 

Ochi N, Nakamura M, Nagata R, Wakasa N, Nakano R, Igaki T. Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2α. PLoS Genet. 2021;17:e1009958.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oliver ER, Saunders TL, Tarlé SA, Glaser T. Ribosomal protein L24 defect in Belly spot and tail (Bst), a mouse Minute. Development. 2004;131:3907–20.

Article  CAS  PubMed  Google Scholar 

Tyler DM, Li W, Zhuo N, Pellock B, Baker NE. Genes affecting cell competition in Drosophila. Genetics. 2007;175:643–57.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Neto-Silva RM, de Beco S, Johnston LA. Evidence for a growth-stabilizing regulatory feedback mechanism between myc and yorkie, the Drosophila homolog of yap. Dev Cell. 2010;19:507–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mamada H, Sato T, Ota M, Sasaki H. Cell competition in mouse NIH3T3 embryonic fibroblasts controlled by Tead activity and Myc. J Cell Sci https://doi.org/10.1242/jcs.163675 (2015).

Rhiner C, López-Gay JM, Soldini D, Casas-Tinto S, Martín FA, Lombardía L, et al. Flower forms an extracellular code that reveals the fitness of a cell to its neighbors in Drosophila. Dev Cell. 2010;18:985–98.

Article  CAS  PubMed  Google Scholar 

Merino MM, Rhiner C, Lopez-Gay JM, Buechel D, Hauert B, Moreno E. Elimination of unfit cells maintains tissue health and prolongs lifespan. Cell. 2015;160:461–76.

Article  CAS  PubMed  PubMed Central