[1] GBD 2017 Causes of Death Collaborators. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018; 392: 1736−1788. doi: 10.1016/S0140-6736(18)32203-7 [2] Roth GA, Mensah GA, Johnson CO, et al. Global burden of cardiovascular diseases and risk factors, 1990–2019: update from the GBD 2019 Study. J Am Coll Cardiol 2020; 76: 2982−3021. doi: 10.1016/j.jacc.2020.11.010 [3] Zhao D, Liu J, Wang M, et al. Epidemiology of cardiovascular disease in China: current features and implications. Nat Rev Cardiol 2019; 16: 203−212. doi: 10.1038/s41569-018-0119-4 [4] Liu S, Li Y, Zeng X, et al. Burden of cardiovascular diseases in China, 1990–2016: findings from the 2016 Global Burden of Disease study. JAMA Cardiol 2019; 4: 342−352. doi: 10.1001/jamacardio.2019.0295 [5] Yusuf S, Joseph P, Rangarajan S, et al. Modifiable risk factors, cardiovascular disease, and mortality in 155,722 individuals from 21 high-income, middle-income, and low-income countries (PURE): a prospective cohort study. La ncet 2020; 395: 795−808. doi: 10.1016/S0140-6736(19)32008-2 [6] Madsen CM, Varbo A, Nordestgaard BG. Extreme high high-density lipoprotein cholesterol is paradoxically associated with high mortality in men and women: two prospective cohort studies. Eur Heart J 2017; 38: 2478−2486. doi: 10.1093/eurheartj/ehx163 [7] Ravnskov U, Diamond DM, Hama R, et al. Lack of an association or an inverse association between low-density lipoprotein cholesterol and mortality in the elderly: a systematic review. BMJ Open 2016; 6: e010401. doi: 10.1136/bmjopen-2015-010401 [8] Lv YB, Mao C, Gao X, et al. Triglycerides paradox among the oldest old: “the lower the better?”. J Am Geriatr Soc 2019; 67: 741−748. doi: 10.1111/jgs.15733 [9] Orkaby AR. The highs and lows of cholesterol: a paradox of healthy aging?. J Am Geriatr Soc 2020; 68: 236−237. doi: 10.1111/jgs.16302 [10] Hamazaki T, Okuyama H, Ogushi Y, et al. Towards a paradigm shift in cholesterol treatment. A re-examination of the cholesterol issue in Japan. Ann Nutr Metab 2015; 66: 1−116. doi: 10.1159/000381654 [11] Lewington S, Whitlock G, Clarke R, et al. Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet 2007; 370: 1829−1839. doi: 10.1016/S0140-6736(07)61778-4 [12] He Y, Li XY, Yang HB, et al. [Beijing Elderly Comprehensive Health Cohort Study: study design and preliminary results]. Chin J Prev Contr Chron Dis 2022; 30: 938−943. [In Chinese]. doi: 10.16386/j.cjpccd.issn.1004-6194.2022.12.012 [13] He Y, Lam TH, Jiang B, et al. Combined effects of tobacco smoke exposure and metabolic syndrome on cardiovascular risk in older residents of China. J Am Coll Cardiol 2009; 53: 363−371. doi: 10.1016/j.jacc.2008.08.073 [14] He Y, Jiang B, Wang J, et al. Prevalence of the metabolic syndrome and its relation to cardiovascular disease in an elderly Chinese population. J Am Coll Cardiol 2006; 47: 1588−1594. doi: 10.1016/j.jacc.2005.11.074 [15] Li JJ, Zhao SP, Zhao D, et al. 2023 Chinese guideline for lipid management. Front Pharmacol 2023; 14: 1190934. doi: 10.3389/fphar.2023.1190934 [16] Nordestgaard BG, Langsted A, Mora S, et al. Fasting is not routinely required for determination of a lipid profile: clinical and laboratory implications including flagging at desirable concentration cut-points-a joint consensus statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine. Eur Heart J 2016; 37: 1944−1958. doi: 10.1093/eurheartj/ehw152 [17] [18] Castañer O, Pintó X, Subirana I, et al. Remnant cholesterol, not LDL cholesterol, is associated with incident cardiovascular disease. J Am Coll Cardiol 2020; 76: 2712−2724. doi: 10.1016/j.jacc.2020.10.008 [19] Hussain A, Sun C, Selvin E, et al. Triglyceride-rich lipoproteins, apolipoprotein C-III, angiopoietin-like protein 3, and cardiovascular events in older adults: Atherosclerosis Risk in Communities (ARIC) study. Eur J Prev Cardiol 2022; 29: e53−e64. doi: 10.1093/eurjpc/zwaa152 [20]

Du X, Ding J, Ma X, et al. Remnant cholesterol has an important impact on increased carotid intima-media thickness in non-diabetic individuals. Int J Cardiovasc Imaging 2023.

[21] Ko DT, Alter DA, Guo H, et al. High-density lipoprotein cholesterol and cause-specific mortality in individuals without previous cardiovascular conditions: the CANHEART study. J Am Coll Cardiol 2016; 68: 2073−2083. doi: 10.1016/j.jacc.2016.08.038 [22] Oh IH, Hur JK, Ryoo JH, et al. Very high high-density lipoprotein cholesterol is associated with increased all-cause mortality in South Koreans. Atherosclerosis 2019; 283: 43−51. doi: 10.1016/j.atherosclerosis.2019.01.035 [23] Mørland JG, Magnus P, Vollset SE, et al. Associations between serum high-density lipoprotein cholesterol levels and cause-specific mortality in a general population of 345,000 men and women aged 20–79 years. Int J Epidemiol 2023; 52: 1257−1267. doi: 10.1093/ije/dyad011