Li J, Ma X, Chakravarti D, Shalapour S, DePinho RA (2021) Genetic and biological hallmarks of colorectal cancer. Genes Dev 35(11–12):787–820

CAS  PubMed  PubMed Central  Google Scholar 

Sedlak JC, Yilmaz ÖH, Roper J (2023) Metabolism and colorectal cancer. Annu Rev Pathol 24(18):467–492

Google Scholar 

Vultaggio-Poma V, Sarti AC, Di Virgilio F (2020) Extracellular ATP: a feasible target for cancer therapy. Cells 9(11):2496

CAS  PubMed  PubMed Central  Google Scholar 

Yegutkin GG, Boison D (2022) ATP and adenosine metabolism in cancer: exploitation for therapeutic gain. Pharmacol Rev 74(3):797–822

PubMed  Google Scholar 

Di Virgilio F, Sarti AC, Falzoni S, De Marchi E, Adinolfi E (2018) Extracellular ATP and P2 purinergic signalling in the tumour microenvironment. Nat Rev Cancer 18(10):601–618

PubMed  Google Scholar 

Roliano GG, Azambuja JH, Brunetto VT, Butterfield HE, Kalil AN, Braganhol E (2022) Colorectal cancer and purinergic signalling: an overview. Cancers (Basel) 14(19):4887

CAS  PubMed  Google Scholar 

Gendron FP, Placet M, Arguin G (2017) P2Y2 receptor functions in cancer: a perspective in the context of colorectal cancer. Adv Exp Med Biol 1051:91–106

CAS  PubMed  Google Scholar 

Zhang WJ (2021) Effect of P2X purinergic receptors in tumor progression and as a potential target for anti-tumor therapy. Purinergic Signal 17(1):151–162

CAS  PubMed  PubMed Central  Google Scholar 

Di Virgilio F, Falzoni S, Giuliani AL, Adinolfi E (2016) P2 receptors in cancer progression and metastatic spreading. Curr Opin Pharmacol 29:17–25

PubMed  Google Scholar 

Bernardazzi C, Castelo-Branco MTL, Pêgo B, Ribeiro BE, Rosas SLB, Santana PT, Machado JC, Leal C, Thompson F, Coutinho-Silva R, de Souza HSP (2022) The P2X7 receptor promotes colorectal inflammation and tumorigenesis by modulating gut microbiota and the inflammasome. Int J Mol Sci 23(9):4616

CAS  PubMed  PubMed Central  Google Scholar 

Künzli BM, Bernlochner MI, Rath S, Käser S, Csizmadia E, Enjyoji K, Cowan P, d’Apice A, Dwyer K, Rosenberg R, Perren A, Friess H, Maurer CA, Robson SC (2011) Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer. Purinergic Signal 7(2):231–241

PubMed  PubMed Central  Google Scholar 

Arneth B (2019) Tumor Microenvironment. Medicina (Kaunas) 56(1):15

PubMed  Google Scholar 

Zhang WJ, Hu CG, Zhu ZM, Luo HL (2020) Effect of P2X7 receptor on tumorigenesis and its pharmacological properties. Biomed Pharmacother 125:109844

CAS  PubMed  Google Scholar 

Han S, Wang W, Wang S, Yang T, Zhang G, Wang D, Ju R, Lu Y, Wang H, Wang L (2021) Tumor microenvironment remodeling and tumor therapy based on M2-like tumor associated macrophage-targeting nano-complexes. Theranostics 11(6):2892–2916

CAS  PubMed  PubMed Central  Google Scholar 

Alvarez CL, Troncoso MF, Espelt MV (2022) Extracellular ATP and adenosine in tumor microenvironment: roles in epithelial-mesenchymal transition, cell migration, and invasion. J Cell Physiol 237(1):389–400

CAS  PubMed  Google Scholar 

Luo Y, Qiao B, Zhang P, Yang C, Cao J, Yuan X, Ran H, Wang Z, Hao L, Cao Y, Ren J, Zhou Z (2020) TME-activatable theranostic nanoplatform with ATP burning capability for tumor sensitization and synergistic therapy. Theranostics 10(15):6987–7001

CAS  PubMed  PubMed Central  Google Scholar 

Ge Q, Jia D, Cen D, Qi Y, Shi C, Li J, Sang L, Yang LJ, He J, Lin A, Chen S, Wang L (2021) Micropeptide ASAP encoded by LINC00467 promotes colorectal cancer progression by directly modulating ATP synthase activity. J Clin Invest 131(22):e152911

CAS  PubMed  PubMed Central  Google Scholar 

Qian Y, Wang X, Liu Y, Li Y, Colvin RA, Tong L, Wu S, Chen X (2014) Extracellular ATP is internalized by macropinocytosis and induces intracellular ATP increase and drug resistance in cancer cells. Cancer Lett 351(2):242–251

CAS  PubMed  Google Scholar 

Wang X, Li Y, Qian Y, Cao Y, Shriwas P, Zhang H, Chen X (2017) Extracellular ATP, as an energy and phosphorylating molecule, induces different types of drug resistances in cancer cells through ATP internalization and intracellular ATP level increase. Oncotarget 8(50):87860–87877

PubMed  PubMed Central  Google Scholar 

Sameiyan E, Bagheri E, Dehghani S, Ramezani M, Alibolandi M, Abnous K, Taghdisi SM (2021) Aptamer-based ATP-responsive delivery systems for cancer diagnosis and treatment. Acta Biomater 15(123):110–122

Google Scholar 

Zhang J, Wang Y, Chen J, Liang X, Han H, Yang Y, Li Q, Wang Y (2017) Inhibition of cell proliferation through an ATP-responsive co-delivery system of doxorubicin and Bcl-2 siRNA. Int J Nanomedicine 3(12):4721–4732

Google Scholar 

Kepp O, Bezu L, Yamazaki T, Di Virgilio F, Smyth MJ, Kroemer G, Galluzzi L (2021) ATP and cancer immunosurveillance. EMBO J 40(13):e108130

CAS  PubMed  PubMed Central  Google Scholar 

Feng LL, Cai YQ, Zhu MC, Xing LJ, Wang X (2020) The yin and yang functions of extracellular ATP and adenosine in tumor immunity. Cancer Cell Int 7(20):110

Google Scholar 

Li XY, Moesta AK, Xiao C, Nakamura K, Casey M, Zhang H, Madore J, Lepletier A, Aguilera AR, Sundarrajan A, Jacoberger-Foissac C, Wong C, Dela Cruz T, Welch M, Lerner AG, Spatola BN, Soros VB, Corbin J, Anderson AC, Effern M, Hölzel M, Robson SC, Johnston RL, Waddell N, Smith C, Bald T, Geetha N, Beers C, Teng MWL, Smyth MJ (2019) Targeting CD39 in cancer reveals an extracellular ATP- and inflammasome-driven tumor immunity. Cancer Discov 9(12):1754–1773

CAS  PubMed  PubMed Central  Google Scholar 

Xia C, Yin S, To KKW, Fu L (2023) CD39/CD73/A2AR pathway and cancer immunotherapy. Mol Cancer 22(1):44

CAS  PubMed  PubMed Central  Google Scholar 

Lu JC, Zhang PF, Huang XY, Guo XJ, Gao C, Zeng HY, Zheng YM, Wang SW, Cai JB, Sun QM, Shi YH, Zhou J, Ke AW, Shi GM, Fan J (2021) Amplification of spatially isolated adenosine pathway by tumor-macrophage interaction induces anti-PD1 resistance in hepatocellular carcinoma. J Hematol Oncol 14(1):200

CAS  PubMed  PubMed Central  Google Scholar 

Yang R, Elsaadi S, Misund K, Abdollahi P, Vandsemb EN, Moen SH, Kusnierczyk A, Slupphaug G, Standal T, Waage A, Slørdahl TS, Rø TB, Rustad E, Sundan A, Hay C, Cooper Z, Schuller AG, Woessner R, Borodovsky A, Menu E, Børset M, Sponaas AM (2020) Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade. J Immunother Cancer 8(1):e000610

PubMed  PubMed Central  Google Scholar 

Mao C, Yeh S, Fu J, Porosnicu M, Thomas A, Kucera GL, Votanopoulos KI, Tian S, Ming X (2022) Delivery of an ectonucleotidase inhibitor with ROS-responsive nanoparticles overcomes adenosine-mediated cancer immunosuppression. Sci Transl Med 14(648):eabh1261

CAS  PubMed  PubMed Central  Google Scholar 

Overes IM, Levenga TH, Vos JC, van Horssen-Zoetbrood A, van der Voort R, De Mulder PH, de Witte TM, Dolstra H (2009) Aberrant expression of the hematopoietic-restricted minor histocompatibility antigen LRH-1 on solid tumors results in efficient cytotoxic T cell-mediated lysis. Cancer Immunol Immunother 58(3):429–439

CAS  PubMed  Google Scholar 

Wang K, Fu S, Dong L, Zhang D, Wang M, Wu X, Shen E, Luo L, Li C, Nice EC, Huang C, Zou B (2023) Periplocin suppresses the growth of colorectal cancer cells by triggering LGALS3 (galectin 3)-mediated lysophagy. Autophagy 23:1–19

Google Scholar 

Cortier M, Boina-Ali R, Racoeur C, Paul C, Solary E, Jeannin JF, Bettaieb A (2015) H89 enhances the sensitivity of cancer cells to glyceryl trinitrate through a purinergic receptor-dependent pathway. Oncotarget 6(9):6877–6886

PubMed  PubMed Central  Google Scholar 

Höpfner M, Lemmer K, Jansen A, Hanski C, Riecken EO, Gavish M, Mann B, Buhr H, Glassmeier G, Scherübl H (1998) Expression of functional P2-purinergic receptors in primary cultures of human colorectal carcinoma cells. Biochem Biophys Res Commun 251(3):811–817

PubMed  Google Scholar 

Correale P, Tagliaferri P, Guarrasi R, Caraglia M, Giuliano M, Marinetti MR, Bianco AR, Procopio A (1997) Extracellular adenosine 5’ triphosphate involvement in the death of LAK-engaged human tumor cells via P2X-receptor activation. Immunol Lett 55(2):69–78

CAS  PubMed  Google Scholar 

Zhang Y, Li F, Wang L, Lou Y (2021) A438079 affects colorectal cancer cell proliferation, migration, apoptosis, and pyroptosis by inhibiting the P2X7 receptor. Biochem Biophys Res Commun 18(558):147–153

Google Scholar 

Zhang WJ, Luo C, Huang C, Pu FQ, Zhu JF, Zhu ZM (2021) PI3K/Akt/GSK-3β signal pathway is involved in P2X7 receptor-induced proliferation and EMT of colorectal cancer cells. Eur J Pharmacol 15(899):174041

Google Scholar 

Zhang Y, Ding J, Wang L (2019) The role of P2X7 receptor in prognosis and metastasis of colorectal cancer. Adv Med Sci 64(2):388–394

PubMed  Google Scholar 

Qian F, Xiao J, Hu B, Sun N, Yin W, Zhu J (2017) High expression of P2X7R is an independent postoperative indicator of poor prognosis in colorectal cancer. Hum Pathol 64:61–68

CAS  PubMed  Google Scholar 

Calik I, Calik M, Turken G, Ozercan IH (2020) A promising independent prognostic biomarker in colorectal cancer: P2X7 receptor. Int J Clin Exp Pathol 13(2):107–121

PubMed  PubMed Central  Google Scholar 

Dillard C, Borde C, Mohammad A, Puchois V, Jourdren L, Larsen AK, Sabbah M, Maréchal V, Escargueil AE, Pramil E (2021) Expression pattern of purinergic signaling components in colorectal cancer cells and differential cellular outcomes induced by extracellular ATP and adenosine. Int J Mol Sci 22(21):11472

CAS  PubMed  PubMed Central  Google Scholar 

Bellefeuille SD, Molle CM, Gendron FP (2019) Reviewing the role of P2Y receptors in specific gastrointestinal cancers. Purinergic Signal 15(4):451–463

CAS  PubMed  PubMed Central  Google Scholar 

Delbro DS, Nylund G, Nordgren S (2005) Demonstration of P2Y4 purinergic receptors in the HT-29 human colon cancer cell line. Auton Autacoid Pharmacol 25(4):163–166

CAS  PubMed  Google Scholar 

Schneider R, Leven P, Glowka T, Kuzmanov I, Lysson M, Schneiker B, Miesen A, Baqi Y, Spanier C, Grants I, Mazzotta E, Villalobos-Hernandez E, Kalff JC, Müller CE, Christofi FL, Wehner S (2021) A novel P2X2-dependent purinergic mechanism of enteric gliosis in intestinal inflammation. EMBO Mol Med 13(1):e12724

CAS