Høvding G. Acute bacterial conjunctivitis. Acta Ophthalmol. 2008;86:5–17.

Article  PubMed  Google Scholar 

Gupta H, Aqil M, Khar RK, Ali A, Bhatnagar A, Mittal G. Biodegradable levofloxacin nanoparticles for sustained ocular drug delivery. J Drug Target. 2011;19:409–17.

Article  CAS  PubMed  Google Scholar 

El-Sayed MM, Hussein AK, Sarhan HA, Mansour HF. Flurbiprofen-loaded niosomes-in-gel system improves the ocular bioavailability of flurbiprofen in the aqueous humor. Drug Dev Ind Pharm [Internet]. Taylor & Francis. 2017;43:902–10. Available from: https://doi.org/10.1080/03639045.2016.1272120

Sahin A, Caban-Toktas S, Tonbul H, Yerlikaya F, Aktas Y, Capan Y. Development of paclitaxel and flurbiprofen Co-loaded PLGA nanoparticles: understanding critical formulation and process parameters using Plackett–Burman design. Istanbul J Pharm. 2019.

Yang H, Li J, Patel SK, Palmer KE, Devlin B, Rohan LC. Design of poly(lactic-co-glycolic acid) (plga) nanoparticles for vaginal co-delivery of griffthsin and dapivirine and their synergistic effect for hiv prophylaxis. Pharmaceutics. 2019;11:1–21.

Article  Google Scholar 

Janagam DR, Wu L, Lowe TL. Nanoparticles for drug delivery to the anterior segment of the eye. Adv Drug Deliv Rev. 2017;122:31–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Al-Nemrawi NK, Alshraiedeh NH, Zayed AL, Altaani BM. Low molecular weight chitosan-coated PLGA nanoparticles for pulmonary delivery of tobramycin for cystic fibrosis. Pharmaceuticals. 2018;11.

Gadad A, Dandagi P, Mastiholimath V. Moxifloxacin loaded polymeric nanoparticles for sustained ocular drug delivery. Int J Pharm Sci Nanotech. 2012;5:1727–34.

Google Scholar 

Arafa MG, Girgis GNS, El-Dahan MS. Chitosan-coated PLGA nanoparticles for enhanced ocular anti-inflammatory efficacy of atorvastatin calcium. Int J Nanomedicine. 2020;15:1335–47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jain GK, Pathan SA, Akhter S, Jayabalan N, Talegaonkar S, Khar RK, et al. Microscopic and spectroscopic evaluation of novel PLGA-chitosan nanoplexes as an ocular delivery system. Colloids Surfaces B Biointerfaces [Internet]. Elsevier B.V. 2011;82:397–403. Available from: https://doi.org/10.1016/j.colsurfb.2010.09.010

Öztürk AA, Yenilmez E, Şenel B, Kıyan HT, Güven UM. Effect of different molecular weight PLGA on flurbiprofen nanoparticles: formulation, characterization, cytotoxicity, and in vivo anti-inflammatory effect by using HET-CAM assay. Drug Dev Ind Pharm [Internet]. Taylor & Francis. 2020;46:682–95. Available from: https://doi.org/10.1080/03639045.2020.1755304

Mahboobian MM, Seyfoddin A, Aboofazeli R, Foroutan SM, Rupenthal ID. Brinzolamide–loaded nanoemulsions: ex vivo transcorneal permeation, cell viability and ocular irritation tests. Pharm Dev Technol. 2019;24:600–6.

Article  CAS  PubMed  Google Scholar 

Ansari M, Sadarani B, Majumdar A. Optimization and evaluation of mucoadhesive buccal films loaded with resveratrol. J Drug Deliv Sci Technol [Internet]. Elsevier; 2018;44:278–88. Available from: https://doi.org/10.1016/j.jddst.2017.12.007

Cazedey ECL, Carvalho FC, Fiorentino FAM, Gremião MPD, Salgado HRN. Corrositex®, BCOP and HET-CAM as alternative methods to animal experimentation. Brazilian J Pharm Sci. 2009;45:759–66.

Article  CAS  Google Scholar 

Luepke NP. Hen’s egg chorioallantoic membrane test for irritation potential. Food Chem Toxicol. 1985;23:287–91.

Article  CAS  PubMed  Google Scholar 

Rangel KC, Villela LZ, Pereira K de C, Colepicolo P, Debonsi HM, Gaspar LR. Assessment of the photoprotective potential and toxicity of Antarctic red macroalgae extracts from Curdiea racovitzae and Iridaea cordata for cosmetic use. Algal Res [Internet]. Elsevier; 2020;50:101984. Available from: https://doi.org/10.1016/j.algal.2020.101984

Mohee R, Mudhoo A. Analysis of the physical properties of an in-vessel composting matrix. Powder Technol. 2005;155:92–9.

Article  CAS  Google Scholar 

Veemvoemg ML. Flurbiprofen loaded biodegradable nanoparticles for ophtalmic administration. J Pharm Sci. 2006;95:2393–405.

Article  Google Scholar 

Shinde UA, Joshi PN, Jain DD, Singh K. Preparation and evaluation of N-trimethyl chitosan nanoparticles of flurbiprofen for ocular delivery. Curr Eye Res [Internet]. Taylor & Francis; 2019;44:575–82. Available from: https://doi.org/10.1080/02713683.2019.1567793

Pandit J, Sultana Y, Aqil M. Chitosan-coated PLGA nanoparticles of bevacizumab as novel drug delivery to target retina: optimization, characterization, and in vitro toxicity evaluation. Artif Cells, Nanomedicine Biotechnol [Internet]. Informa UK Limited, trading as Taylor 8 Francis Group. 2017;45:1397–407. Available from: https://doi.org/10.1080/21691401.2016.1243545

Zhang Y, Huo M, Zhou J, Zou A, Li W, Yao C, et al. DDSolver: an add-in program for modeling and comparison of drug dissolution profiles. AAPS J. 2010;12:263–71.

Article  PubMed  PubMed Central  Google Scholar 

Huang X, Brazel CS. On the importance and mechanisms of burst release in matrix-controlled drug delivery systems. J Control Release. 2001;73:121–36.

Article  CAS  PubMed  Google Scholar