MeSH 搜索器

Gene Amplification

A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.
推出的年份: 1980
副标题
树号: G05.308.250, G05.365.590.310, G05.558.315
MeSH 单一 ID: D005784
进入的组:
  • Amplification, Gene
早前的内容:
  • Genes (1966-1967)
  • Genes, Structural (1968-1979)
  • Nucleic Acid Hybridization (1971-1979)
  • Plasmids (1975-1979)

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