A secreted protein of approximately 131 amino acids (depending on species) that regulates the synthesis of eumelanin (brown/black) pigments in MELANOCYTES. Agouti protein antagonizes the signaling of MELANOCORTIN RECEPTORS and has wide distribution including ADIPOSE TISSUE; GONADS; and HEART. Its overexpression in agouti mice results in uniform yellow coat color, OBESITY, and metabolic defects similar to type II diabetes in humans.
推出的年份: 2008(1993)
副标题
树号: D12.644.276.049, D12.776.467.049, D23.529.049
MeSH 单一 ID: D054366
进入的组:
ASIP Protein
Agouti Protein
Agouti Switch Protein
早前的内容:
Intercellular Signaling Peptides and Proteins (1994-2007)
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