An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.
推出的年份: 2000
副标题
树号: G02.111.820.560, G03.493.560, G04.835.560
MeSH 单一 ID: D020935
进入的组:
ERK1-2 Pathway
ERK1 2 Pathway
ERK1-2 Pathways
Pathway, ERK1-2
Pathways, ERK1-2
ERK1 and ERK2 Pathway
p38 Kinase Pathway
Kinase Pathway, p38
Kinase Pathways, p38
Pathway, p38 Kinase
Pathways, p38 Kinase
p38 Kinase Pathways
p38 Kinase Signaling Pathway
MAP Kinase Cascade
Cascade, MAP Kinase
Kinase Cascade, MAP
MAP Kinase Cascades
MAP Kinase Signaling Cascades
MAP Kinase Signaling Cascade
MAP Kinase Modules
Module, MAP Kinase
MAP Kinase Module
MAP Kinase Signaling Pathways
MAP Kinase Signaling Pathway
MEK-ERK Pathway
MEK ERK Pathway
MEK-ERK Pathways
Pathway, MEK-ERK
Pathways, MEK-ERK
ERK Signal Tranduction Pathway
ERK Pathway
ERK Pathways
Pathway, ERK
Pathways, ERK
JNK Pathway
JNK Pathways
Pathway, JNK
Pathways, JNK
JNK Signaling Pathway
JNK Signaling Pathways
Pathway, JNK Signaling
Pathways, JNK Signaling
Signaling Pathway, JNK
Signaling Pathways, JNK
早前的内容:
Ca(2+)-Calmodulin Dependent Protein Kinase (1994-1999)
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