MeSH 搜索器

Antineoplastic Agents, Alkylating

A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
推出的年份: 1996
副标题
树号: D27.505.519.124.035, D27.505.954.248.150, D27.888.569.035.035
MeSH 单一 ID: D018906
进入的组:
  • Alkylating Antineoplastic Agents
  • Alkylating Antineoplastic Drugs
  • Alkylating Antineoplastics
  • Antineoplastic Alkylating Agents
  • Antineoplastic Drugs, Alkylating
  • Antineoplastics, Alkylating
  • Alkylating Agents, Antineoplastic
  • Alkylating Drugs, Antineoplastic
  • Antineoplastic Alkylating Drugs
  • Drugs, Antineoplastic Alkylating
早前的内容:
  • Alkylating Agents (1966-1995)
  • Antineoplastic Agents (1966-1995)

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