MeSH 搜索器

PR-SET Domains

Highly conserved protein domains of approximately 130 to 140 amino acids. The SET domain was first identified in the Drosophila proteins (S)u(var)3-9, (E)nhancer-of-zeste and (T)rithorax and occurs in other proteins with a variety of functions, including histone-lysine N-methyltransferases. Structurally, it consists of BETA-SHEETS interspersed among loops and turns that result in an "L" shape. The most conserved motifs are a stretch at the C-terminal that contains a strictly conserved tyrosine residue and an adjacent loop that the C-terminal segment passes through to form a "knot". These motifs and especially the tyrosine residue are essential for S-ADENOSYLMETHIONINE binding and catalysis. The PR domain has high homology to the catalytic region of the SET domain and occurs at the N-terminal of PRDM proteins such as PRDM1 PROTEIN.
推出的年份: 2018
副标题
树号: G02.111.570.820.709.275.750.477
MeSH 单一 ID: D000074463
进入的组:
  • Domain, PR-SET
  • Domains, PR-SET
  • PR SET Domains
  • PR-SET Domain
  • SET Domain
  • Domain, SET
  • Domains, SET
  • SET Domains
  • PR Domain
  • Domain, PR
  • Domains, PR
  • PR Domains
早前的内容:
  • Amino Acid Sequence (1996-2017)
  • Histone-Lysine N-Methyltransferase (1996-2017)

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