Gimelli A, Liga R, Agostini D, Bengel FM, Ernst S, Hyafil F, et al. The role of myocardial innervation imaging in different clinical scenarios: an expert document of the European Association of Cardiovascular Imaging and Cardiovascular Committee of the European Association of Nuclear Medicine. Eur Heart J Cardiovasc Imaging. 2021;22(5):480–90. https://doi.org/10.1093/ehjci/jeab007.

Article  PubMed  Google Scholar 

Gargiulo P, Acampa W, Asile G, Abbate V, Nardi E, Marzano F, et al. 123I-MIBG imaging in heart failure: impact of comorbidities on cardiac sympathetic innervation. Eur J Nucl Med Mol Imaging. 2023;50(3):813–24. https://doi.org/10.1007/s00259-022-05941-3.

Article  PubMed  Google Scholar 

Pontico M, Brunotti G, Conte M, Corica F, Cosma L, De Angelis C, et al. The prognostic value of 123I-mIBG SPECT cardiac imaging in heart failure patients: a systematic review. J Nucl Cardiol. 2022;29(4):1799–809. https://doi.org/10.1007/s12350-020-02501-w.

Article  PubMed  Google Scholar 

Verschure DO, Nakajima K, Verberne HJ. Cardiac 123I-mIBG Imaging in Heart Failure. Pharmaceuticals (Basel). 2022;15(6):656. https://doi.org/10.3390/ph15060656.

Article  CAS  PubMed  Google Scholar 

Jacobson AF, Senior R, Cerqueira MD, Wong ND, Thomas GS, Lopez VA, et al. Myocardial iodine-123 meta-iodobenzylguanidine imaging and cardiac events in heart failure. Results of the prospective ADMIRE-HF (AdreView Myocardial Imaging for Risk Evaluation in Heart Failure) study. J Am Coll Cardiol. 2010; 55(20):2212–21 https://doi.org/10.1016/j.jacc.2010.01.014.

Hachamovitch R, Nutter B, Menon V, Cerqueira MD. Predicting risk versus predicting potential survival benefit using 123I-mIBG imaging in patients with systolic dysfunction eligible for implantable cardiac defibrillator implantation: analysis of data from the prospective ADMIRE-HF study. Circ Cardiovasc Imaging. 2015;12:e003110. https://doi.org/10.1161/CIRCIMAGING.114.003110.

Article  Google Scholar 

Gimelli A, Liga R, Menichetti F, Soldati E, Bongiorni MG, Marzullo P. Interactions between myocardial sympathetic denervation and left ventricular mechanical dyssynchrony: a CZT analysis. J Nucl Cardiol. 2019;26(2):509–18. https://doi.org/10.1007/s12350-017-1036-3.

Article  PubMed  Google Scholar 

Mishkina AI, Saushkin VV, Atabekov TA, Sazonova SI, Shipulin VV, Massalha S, et al. The value of cardiac sympathetic activity and mechanical dyssynchrony as cardiac resynchronization therapy response predictors: comparison between patients with ischemic and non-ischemic heart failure. J Nucl Cardiol. 2023;30(1):371–82. https://doi.org/10.1007/s12350-022-03046-w.

Article  PubMed  Google Scholar 

Assante R, Acampa W. Dual isotope and multidetector camera: the best choices for a specific end-point. J Nucl Cardiol. 2017;24(4):1370–3. https://doi.org/10.1007/s12350-016-0520-5.

Article  PubMed  Google Scholar 

Cantoni V, Green R, Acampa W, Zampella E, Assante R, Nappi C, et al. Diagnostic performance of myocardial perfusion imaging with conventional and CZT single-photon emission computed tomography in detecting coronary artery disease: a meta-analysis. J Nucl Cardiol. 2021;28(2):698–715. https://doi.org/10.1007/s12350-019-01747-3.

Article  PubMed  Google Scholar 

Gimelli A, Liga R, Giorgetti A, Genovesi D, Marzullo P. Assessment of myocardial adrenergic innervation with a solid-state dedicated cardiac cadmium-zinc-telluride camera: first clinical experience. Eur Heart J Cardiovasc Imaging. 2014;15(5):575–85. https://doi.org/10.1093/ehjci/jet258.

Article  PubMed  Google Scholar 

Acampa W, Buechel RR, Gimelli A. Low dose in nuclear cardiology: state of the art in the era of new cadmium-zinc-telluride cameras. Eur Heart J Cardiovasc Imaging. 2016;17(6):591–5. https://doi.org/10.1093/ehjci/jew036.

Article  PubMed  Google Scholar 

Ben-Haim S, Kacperski K, Hain S, Van Gramberg D, Hutton BF, Erlandsson K, et al. Simultaneous dual-radionuclide myocardial perfusion imaging with a solid-state dedicated cardiac camera. Eur J Nucl Med Mol Imaging. 2010;37(9):1710–21. https://doi.org/10.1007/s00259-010-1441-1.

Article  PubMed  PubMed Central  Google Scholar 

• Bellevre D, Manrique A, Legallois D, Bross S, Baavour R, Roth N, et al. First determination of the heart-to-mediastinum ratio using cardiac dual isotope (123I-MIBG/99mTc-tetrofosmin) CZT imaging in patients with heart failure: the ADRECARD study. Eur J Nucl Med Mol Imaging. 2015;42(12):1912–9. https://doi.org/10.1007/s00259-015-3141-3. This study is relevant as it is the first report of the feasibility of CZT-SPECT SDI protocols in clinical practice by D-SPECT camera.

Article  PubMed  Google Scholar 

• D’estanque E, Hedon C, Lattuca B, Bourdon A, Benkiran M, Verd A, et al. Optimization of a simultaneous dual-isotope 201Tl/123I-MIBG myocardial SPECT imaging protocol with a CZT camera for trigger zone assessment after myocardial infarction for routine clinical settings: are delayed acquisition and scatter correction necessary? J Nucl Cardiol. 2017; 24(4):1361-1369. https://doi.org/10.1007/s12350-016-0524-1. This study is relevant as evaluates the role of SPECT analysis in perfusion/innervation SDI imaging by CZT camera and investigates the real advantages of scatter correction.

• Blaire T, Bailliez A, Ben Bouallegue F, Bellevre D, Agostini D, Manrique A. Determination of the heart-to-mediastinum ratio of 123I-MIBG uptake using dual-isotope (123I-MIBG/99mTc-Tetrofosmin) multipinhole cadmium-zinc-telluride SPECT in patients with heart failure. J Nucl Med. 2018;59(2):251–8. https://doi.org/10.2967/jnumed.117.194373. This study is relevant as it first investigates the late HMR assessment by DNM camera, showing the need to use transaxial images and a linear correction equation to compare CZT-camera results to standard Anger camera.

Article  CAS  PubMed  Google Scholar 

• Assante R, D’Antonio A, Mannarino T, Nappi C, Gaudieri V, Zampella E, et al. Simultaneous assessment of myocardial perfusion and adrenergic innervation in patients with heart failure by low-dose dual-isotope CZT SPECT imaging. J Nucl Cardiol. 2022;29(6):3341–51. https://doi.org/10.1007/s12350-022-02951-4. This study is relevant as it demonstrates the feasibility of low-dose SDI protocol by CZT-SPECT in clinical practice, highlighting the possibility to obtain a full global and regional assessment of cardiac perfusion and innervation study in a single simultaneous acquisition time.

Article  PubMed  PubMed Central  Google Scholar 

Verschure DO, Bongers V, Hagen P, Somsen GA, van Eck-Smit BF, Verberne H. Impact of a predefined mediastinal ROI on interobserver variability of planar 123I-MIBG heart-to-mediastinum ratio. J Nucl Cardiol. 2014;21(3):605–13. https://doi.org/10.1007/s12350-014-9854-z.

Article  PubMed  Google Scholar 

Pellegrino T, Petretta M, De Luca S, Paolillo S, Boemio A, Carotenuto R, et al. Observer reproducibility of results from a low-dose 123I-metaiodobenzylguanidine cardiac imaging protocol in patients with heart failure. Eur J Nucl Med Mol Imaging. 2013;40(10):1549–57. https://doi.org/10.1007/s00259-013-2461-4.

Article  CAS  PubMed  Google Scholar 

Brumberg J, Blazhenets G, Schröter N, Frings L, Jost WH, Lapa C, et al. Imaging cardiac sympathetic innervation with MIBG: linear conversion of the heart-to-mediastinum ratio between different collimators. EJNMMI Phys. 2019;6(1):12. https://doi.org/10.1186/s40658-019-0250-2.

Article  PubMed  PubMed Central  Google Scholar 

Owenius R, Zanette M, Cella P. Variability in heart-to-mediastinum ratio from planar 123I-MIBG images of a thorax phantom for 6 common γ-camera models. J Nucl Med Technol. 2017;45(4):297–303. https://doi.org/10.2967/jnmt.117.196055.

Article  PubMed  Google Scholar 

Nakajima K, Okuda K, Yoshimura M, Matsuo S, Wakabayashi H, Imanishi Y, et al. Multicenter cross-calibration of I-123 metaiodobenzylguanidine heart-to-mediastinum ratios to overcome camera-collimator variations. J Nucl Cardiol. 2014;21(5):970–8. https://doi.org/10.1007/s12350-014-9916-2.

Article  PubMed  PubMed Central  Google Scholar 

Verschure DO, de Wit TC, Bongers V, Hagen PJ, Sonneck-Koenne C, D’Aron J, et al. 123I-MIBG heart-to-mediastinum ratio is influenced by high-energy photon penetration of collimator septa from liver and lung activity. Nucl Med Commun. 2015;36(3):279–85. https://doi.org/10.1097/MNM.0000000000000238.

Article  PubMed  Google Scholar 

Erlandsson K, Kacperski K, van Gramberg D, Hutton BF. Performance evaluation of D-SPECT: a novel SPECT system for nuclear cardiology. Phys Med Biol. 2009;54(9):2635–49. https://doi.org/10.1088/0031-9155/54/9/003.

Article  PubMed  Google Scholar 

Gambhir SS, Berman DS, Ziffer J, Nagler M, Sandler M, Patton J, Hutton B, Sharir T, Haim SB, Haim SB. A novel high-sensitivity rapid-acquisition single-photon cardiac imaging camera. J Nucl Med. 2009;50(4):635–43. https://doi.org/10.2967/jnumed.108.060020.

Article  PubMed  Google Scholar 

Nakajima K, Okuda K, Yokoyama K, Yoneyama T, Tsuji S, Oda H, et al. Cross calibration of 123I-meta-iodobenzylguanidine heart-to-mediastinum ratio with D-SPECT planogram and Anger camera. Ann Nucl Med. 2017;31(8):605–15. https://doi.org/10.1007/s12149-017-1191-2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Holstensson M, Erlandsson K, Poludniowski G, Ben-Haim S, Hutton BF. Model-based correction for scatter and tailing effects in simultaneous 99mTc and 123I imaging for a CdZnTe cardiac SPECT camera. Phys Med Biol. 2015;60(8):3045–63. https://doi.org/10.1088/0031-9155/60/8/3045.

Article  CAS  PubMed  Google Scholar 

Nakajima K, Verschure DO, Okuda K, Verberne HJ. Standardization of 123I-meta-iodobenzylguanidine myocardial sympathetic activity imaging: phantom calibration and clinical applications. Clin Transl Imaging. 2017;5(3):255–63. https://doi.org/10.1007/s40336-017-0230-2.

Article  PubMed  PubMed Central  Google Scholar 

Verschure DO, Poel E, Nakajima K, Okuda K, van Eck-Smit BLF, Somsen GA, et al. A European myocardial 123I-mIBG cross-calibration phantom study. J Nucl Cardiol. 2018;25(4):1191–7. https://doi.org/10.1007/s12350-017-0782-6.

Article  PubMed  Google Scholar 

Blaire T, Bailliez A, Ben Bouallegue F, Bellevre D, Agostini D, Manrique A. First assessment of simultaneous dual isotope ((123)I/(99m)Tc) cardiac SPECT on two different CZT cameras: a phantom study. J Nucl Cardiol. 2018;25(5):1692–704. https://doi.org/10.1007/s12350-017-0841-z.

Article  PubMed  Google Scholar 

Niimi T, Nanasato M, Sugimoto M, Maeda H. Comparative cardiac phantom study using Tc-99m/I-123 and Tl-201/I-123 tracers with cadmium-zinc-telluride detector-based single-photon emission computed tomography. Nucl Med Mol Imaging. 2019;53(1):57–63. https://doi.org/10.1007/s13139-018-0559-0.

Article  CAS  PubMed  Google Scholar 

Kacperski K, Erlandsson K, Ben-Haim S, Hutton BF. Iterative deconvolution of simultaneous 99mTc and 201Tl projection data measured on a CdZnTe-based cardiac SPECT scanner. Phys Med Biol. 2011;56(5):1397–414. https://doi.org/10.1088/0031-9155/56/5/012.

Article  PubMed  PubMed Central  Google Scholar 

Sood N, Al Badarin F, Parker M, Pullatt R, Jacobson AF, Bateman TM, et al. Resting perfusion MPI-SPECT combined with cardiac 123I-mIBG sympathetic innervation imaging improves prediction of arrhythmic events in non-ischemic cardiomyopathy patients: sub-study from the ADMIRE-HF trial. J Nucl Cardiol. 2013;20(5):813–20. https://doi.org/10.1007/s12350-013-9750-y.

Article  PubMed  Google Scholar 

Clements IP, Garcia EV, Chen J, Folks RD, Butler J, Jacobson AF. Quantitative iodine-123-metaiodobenzylguanidine (MIBG) SPECT imaging in heart failure with left ventricular systolic dysfunction: development and validation of automated procedures in conjunction with technetium-99m tetrofosmin myocardial perfusion SPECT. J Nucl Cardiol. 2016;23(3):425–35. https://doi.org/10.1007/s12350-015-0097-4.

Article  PubMed  Google Scholar 

Travin MI, Henzlova MJ, van Eck-Smit BLF, Jain D, Carrio I, Folks RD, et al. Assessment of (123)I-mIBG and (99 m)Tctetrofosmin single-photon emission computed tomographic images for the prediction of arrhythmic events in patients with ischemic heart failure: intermediate severity innervation defects are associated with higher arrhythmic risk. J Nucl Cardiol. 2017;24(2):377–91. https://doi.org/10.1007/s12350-015-0336-8.

Article  PubMed