DiMeglio LA, Evans-Molina C, Oram RA. Type 1 diabetes. Lancet. 2018;391:2449–62. https://doi.org/10.1016/S0140-6736(18)31320-5.
Article PubMed PubMed Central Google Scholar
Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K, Duncan BB, Stein C, Basit A, Chan JCN, Mbanya JC, Pavkov ME, Ramachandaran A, Wild SH, James S, Herman WH, Zhang P, Bommer C, Kuo S, Boyko EJ, Magliano DJ. IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2022;183:109119. https://doi.org/10.1016/j.diabres.2021.109119.
Katsarou A, Gudbjörnsdottir S, Rawshani A, Dabelea D, Bonifacio E, Anderson BJ, Jacobsen LM, Schatz DA, Lernmark Å. Type 1 diabetes mellitus. Nat Rev Dis Primers. 2017;3:17016. https://doi.org/10.1038/nrdp.2017.16.
Eisenbarth GS. Type I diabetes mellitus. A chronic autoimmune disease. N Engl J Med. 1986;314:1360–8.
Article CAS PubMed Google Scholar
Umpierrez G, Korytkowski M. Diabetic emergencies-ketoacidosis, hyperglycaemic hyperosmolar state and hypoglycaemia. Nat Rev Endocrinol. 2016;12:222–32. https://doi.org/10.1038/nrendo.2016.15.
Article CAS PubMed Google Scholar
Dhatariya KK, Glaser NS, Codner E, Umpierrez GE. Diabetic ketoacidosis. Nature reviews. Dis Primers. 2020;6:40. https://doi.org/10.1038/s41572-020-0165-1.
Ni Q, Pham NB, Meng WS, Zhu G, Chen X. Advances in immunotherapy of type I diabetes. Adv Drug Deliv Rev. 2019;139:83–91. https://doi.org/10.1016/j.addr.2018.12.003.
Article CAS PubMed Google Scholar
Ilonen J, Lempainen J, Veijola R. The heterogeneous pathogenesis of type 1 diabetes mellitus. Nat Rev Endocrinol. 2019;15:635–50. https://doi.org/10.1038/s41574-019-0254-y.
Article CAS PubMed Google Scholar
Pang H, Xia Y, Luo S, Huang G, Li X, Xie Z, Zhou Z. Emerging roles of rare and low-frequency genetic variants in type 1 diabetes mellitus. J Med Genet. 2021;58:289–96. https://doi.org/10.1136/jmedgenet-2020-107350.
Article CAS PubMed Google Scholar
Torun A, Hupalowska A, Trzonkowski P, Kierkus J, Pyrzynska B. Intestinal microbiota in common chronic inflammatory disorders affecting children. Front Immunol. 2021;12:642166. https://doi.org/10.3389/fimmu.2021.642166.
Article CAS PubMed PubMed Central Google Scholar
Sims EK, Carr ALJ, Oram RA, DiMeglio LA, Evans-Molina C. 100 years of insulin: celebrating the past, present and future of diabetes therapy. Nat Med. 2021;27:1154–64. https://doi.org/10.1038/s41591-021-01418-2.
Article CAS PubMed PubMed Central Google Scholar
Yu X, Zhang S, Zhang L. Newer Perspectives of mechanisms for euglycemic diabetic ketoacidosis. Int J Endocrinol. 2018;2018:7074868. https://doi.org/10.1155/2018/7074868.
Article PubMed PubMed Central Google Scholar
Long B, Lentz S, Koyfman A, Gottlieb M. Euglycemic diabetic ketoacidosis: Etiologies, evaluation, and management. Am J Emerg Med. 2021;44:157–60. https://doi.org/10.1016/j.ajem.2021.02.015.
Thiruvenkatarajan V, Meyer EJ, Nanjappa N, Van Wijk RM, Jesudason D. Perioperative diabetic ketoacidosis associated with sodium-glucose co-transporter-2 inhibitors: a systematic review. Br J Anaesth. 2019;123:27–36. https://doi.org/10.1016/j.bja.2019.03.028.
Article CAS PubMed Google Scholar
Bradley CA. Immunotherapy: PDL1 restoration reverses T1DM. Nat Rev Endocrinol. 2018;14:1. https://doi.org/10.1038/nrendo.2017.165.
Vallianou NG, Stratigou T, Geladari E, Tessier CM, Mantzoros CS, Dalamaga M. Diabetes type 1: can it be treated as an autoimmune disorder? Rev Endocr Metab Disord. 2021;22:859–76. https://doi.org/10.1007/s11154-021-09642-4.
Nagy G, Szekely TE, Somogyi A, Herold M, Herold Z. New therapeutic approaches for type 1 diabetes: disease-modifying therapies. World J Diabetes. 2022;13:835–50. https://doi.org/10.4239/wjd.v13.i10.835.
Article PubMed PubMed Central Google Scholar
Pociot F, Lernmark Å. Genetic risk factors for type 1 diabetes. Lancet. 2016;387:2331–9. https://doi.org/10.1016/S0140-6736(16)30582-7.
Article CAS PubMed Google Scholar
Cabello-Olmo M, Araña M, Radichev I, Smith P, Huarte E, Barajas M. New insights into immunotherapy strategies for treating autoimmune diabetes. Int J Mol Sci. 2019. https://doi.org/10.3390/ijms20194789.
Article PubMed PubMed Central Google Scholar
Wong FS, Wen L. A predictive CD8 T cell phenotype for T1DM progression. Nat Rev Endocrinol. 2020;16:198–9. https://doi.org/10.1038/s41574-020-0330-3.
Article CAS PubMed PubMed Central Google Scholar
Ke Q, Kroger CJ, Clark M, Tisch RM. evolving antibody therapies for the treatment of type 1 diabetes. Front Immunol. 2020;11:624568. https://doi.org/10.3389/fimmu.2020.624568.
Article CAS PubMed Google Scholar
Brown CC, Gudjonson H, Pritykin Y, Deep D, Lavallee VP, Mendoza A, Fromme R, Mazutis L, Ariyan C, Leslie C, Pe’er D, Rudensky AY. Transcriptional basis of mouse and human dendritic cell heterogeneity. Cell. 2019;179:846-863e824. https://doi.org/10.1016/j.cell.2019.09.035.
Article CAS PubMed PubMed Central Google Scholar
Szabo CE, Ilies RF, Aioanei CS, Catana A, Cret V, Serban RS, Pop IV. The role of adiponectin, TNF-alpha and glutathione in the pathogenesis and evolution of type 1 diabetes. Diabetes Metab Syndr Obes. 2019;12:2303–8. https://doi.org/10.2147/DMSO.S220133.
Article CAS PubMed PubMed Central Google Scholar
Tampio J, Markowicz-Piasecka M, Huttunen KM. Hemocompatible L-Type amino acid transporter 1 (LAT1)-Utilizing prodrugs of perforin inhibitors can accumulate into the pancreas and alleviate inflammation-induced apoptosis. Chem Biol Interact. 2021;345:109560. https://doi.org/10.1016/j.cbi.2021.109560.
Article CAS PubMed Google Scholar
Li X, Liao M, Guan J, Zhou L, Shen R, Long M, Shao J. Identification of key genes and pathways in peripheral blood mononuclear cells of type 1 diabetes mellitus by integrated bioinformatics analysis. Diabetes Metab J. 2022;46:451–63. https://doi.org/10.4093/dmj.2021.0018.
Article PubMed PubMed Central Google Scholar
Pugliese A. Autoreactive T cells in type 1 diabetes. J Clin Invest. 2017;127:2881–91. https://doi.org/10.1172/JCI94549.
Article PubMed PubMed Central Google Scholar
Leete P, Willcox A, Krogvold L, Dahl-Jørgensen K, Foulis AK, Richardson SJ, Morgan NG. Differential insulitic profiles determine the extent of β-cell destruction and the age at onset of type 1 diabetes. Diabetes. 2016;65:1362–9. https://doi.org/10.2337/db15-1615.
Article CAS PubMed Google Scholar
Ghonaim MM, El-Edel RH, Kamal Eldein SM, Abo El Fotoh WMM, Salman SS. T-regulatory cell subsets in children with type 1 diabetes mellitus: relation to control of the disease. Endocr Metab Immune Disord Drug Targets. 2017;17:238–45. https://doi.org/10.2174/1871530317666170818115116.
Article CAS PubMed Google Scholar
Jeyam A, Colhoun H, McGurnaghan S, Blackbourn L, McDonald TJ, Palmer CNA, McKnight JA, Strachan MWJ, Patrick AW, Chalmers J, Lindsay RS, Petrie JR, Thekkepat S, Collier A, MacRury S, McKeigue PM. Clinical impact of residual C-peptide secretion in type 1 diabetes on glycemia and microvascular complications. Diabetes Care. 2021;44:390–8. https://doi.org/10.2337/dc20-0567.
Article CAS PubMed Google Scholar
Herold KC, Gitelman SE, Ehlers MR, Gottlieb PA, Greenbaum CJ, Hagopian W, Boyle KD, Keyes-Elstein L, Aggarwal S, Phippard D, Sayre PH, McNamara J, Bluestone JA. Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: metabolic and immunologic features at baseline identify a subgroup of responders. Diabetes. 2013;62:3766–74. https://doi.org/10.2337/db13-0345.
Article CAS PubMed PubMed Central Google Scholar
Rigby MR, DiMeglio LA, Rendell MS, Felner EI, Dostou JM, Gitelman SE, Patel CM, Griffin KJ, Tsalikian E, Gottlieb PA, Greenbaum CJ, Sherry NA, Moore WV, Monzavi R, Willi SM, Raskin P, Moran A, Russell WE, Pinckney A, Keyes-Elstein L, Howell M, Aggarwal S, Lim N, Phippard D, Nepom GT, McNamara J, Ehlers MR. Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial. Lancet Diabetes Endocrinol. 2013;1:284–94. https://doi.org/10.1016/S2213-8587(13)70111-6.
Article CAS PubMed PubMed Central Google Scholar
Akil AA-S, Yassin E, Al-Maraghi A, Aliyev E, Al-Malki K, Fakhro KA. Diagnosis and treatment of type 1 diabetes at the dawn of the personalized medicine era. J Transl Med. 2021;19:137. https://doi.org/10.1186/s12967-021-02778-6.
Article CAS PubMed PubMed Central Google Scholar
Morgan NG. Bringing the human pancreas into focus: new paradigms for the understanding of Type 1 diabetes. Diabet Med. 2017;34:879–86. https://doi.org/10.1111/dme.13365.
Article CAS PubMed Google Scholar
Eizirik DL, Pasquali L, Cnop M. Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure. Nat Rev Endocrinol. 2020;16:349–62. https://doi.org/10.1038/s41574-020-0355-7.
留言 (0)