Monoclonal Antibody Generation Using Single B Cell Screening for Treating Infectious Diseases

Morse SS. Factors in the emergence of infectious diseases. Emerg Infect Dis. 1995;1:7–15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baker RE, Mahmud AS, Miller IF, Rajeev M, Rasambainarivo F, Rice BL, et al. Infectious disease in an era of global change. Nat Rev Microbiol. 2022;20:193–205.

Article  CAS  PubMed  Google Scholar 

Dropulic LK, Lederman HM. Overview of infections in the immunocompromised host. Microbiol Spectr. 2016;4.

Agrati C, Bartolini B, Bordoni V, Locatelli F, Capobianchi MR, Di Caro A, et al. Emerging viral infections in immunocompromised patients: a great challenge to better define the role of immune response. Front Immunol. 2023;14:1147871.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Excler J-L, Ake J, Robb ML, Kim JH, Plotkin SA. Nonneutralizing functional antibodies: a new “old” paradigm for HIV vaccines. Clin Vaccine Immunol. 2014;21:1023–36.

Article  PubMed  PubMed Central  Google Scholar 

Doria-Rose NA, Joyce MG. Strategies to guide the antibody affinity maturation process. Curr Opin Virol. 2015;11:137–47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

He W, Tan GS, Mullarkey CE, Lee AJ, Lam MMW, Krammer F, et al. Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus. Proc Natl Acad Sci USA. 2016;113:11931–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wagner EK, Maynard JA. Engineering therapeutic antibodies to combat infectious diseases. Curr Opin Chem Eng. 2018;19:131–41.

Article  PubMed  PubMed Central  Google Scholar 

Whaley KJ, Zeitlin L. Emerging antibody-based products for infectious diseases: planning for metric ton manufacturing. Hum Vaccin Immunother. 2022;18:1930847.

Article  PubMed  Google Scholar 

Parray HA, Shukla S, Samal S, Shrivastava T, Ahmed S, Sharma C, et al. Hybridoma technology a versatile method for isolation of monoclonal antibodies, its applicability across species, limitations, advancement and future perspectives. Int Immunopharmacol. 2020;85: 106639.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mitra S, Tomar PC. Hybridoma technology; advancements, clinical significance, and future aspects. J Genet Eng Biotechnol. 2021;19:159.

Article  PubMed  PubMed Central  Google Scholar 

Zhang C. Hybridoma technology for the generation of monoclonal antibodies. Methods Mol Biol. 2012;901:117–35.

Article  CAS  PubMed  Google Scholar 

Smith SA, Crowe JEJ. Use of human hybridoma technology to isolate human monoclonal antibodies. Microbiol Spectr. 2015;3:AID-0027-2014.

Foltz I, Gunasekaran K, King C. Discovery and bio-optimization of human antibody therapeutics using the XenoMouse ® transgenic mouse platform. Immunol Rev. 2016;270:51–64.

Article  CAS  PubMed  Google Scholar 

Laffleur B, Pascal V, Sirac C, Cogné M. Production of human or humanized antibodies in mice. Methods Mol Biol. 2012;901:149–59.

Article  CAS  PubMed  Google Scholar 

Mullen TE, Abdullah R, Boucher J, Brousseau AS, Dasuri NK, Ditto NT, et al. Accelerated antibody discovery targeting the SARS-CoV-2 spike protein for COVID-19 therapeutic potential. Antib Ther. 2021;4:185–96.

CAS  PubMed  PubMed Central  Google Scholar 

Schardt JS, Pornnoppadol G, Desai AA, Park KS, Zupancic JM, Makowski EK, et al. Discovery and characterization of high-affinity, potent SARS-CoV-2 neutralizing antibodies via single B cell screening. Sci Rep. 2021;11:20738.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tanno H, McDaniel JR, Stevens CA, Voss WN, Li J, Durrett R, et al. A facile technology for the high-throughput sequencing of the paired VH:VL and TCRβ:TCRα repertoires. Sci Adv. 2020;6.

Wang B, DeKosky BJ, Timm MR, Lee J, Normandin E, Misasi J, et al. Functional interrogation and mining of natively paired human VH:VL antibody repertoires. Nat Biotechnol. 2018;36:152–5.

Article  PubMed  PubMed Central  Google Scholar 

DeKosky BJ, Kojima T, Rodin A, Charab W, Ippolito GC, Ellington AD, et al. In-depth determination and analysis of the human paired heavy- and light-chain antibody repertoire. Nat Med. 2015;21:86–91.

Article  CAS  PubMed  Google Scholar 

DeKosky BJ, Ippolito GC, Deschner RP, Lavinder JJ, Wine Y, Rawlings BM, et al. High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire. Nat Biotechnol. 2013;31:166–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Williams LD, Ofek G, Schätzle S, Mcdaniel JR, Lu X, Nicely NI, et al. Potent and broad HIV-neutralizing antibodies in memory B cells and plasma. Sci Immunol. 2017;2:eaal2200.

Xiao X, Tang A, Cox KS, Wen Z, Callahan C, Sullivan NL, et al. Characterization of potent RSV neutralizing antibodies isolated from human memory B cells and identification of diverse RSV/hMPV cross-neutralizing epitopes. MAbs. 2019;11:1415–27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lerner RA. Combinatorial antibody libraries: new advances, new immunological insights. Nat Rev Immunol. 2016;16:498–508.

Article  CAS  PubMed  Google Scholar 

Ponsel D, Neugebauer J, Ladetzki-Baehs K, Tissot K. High affinity, developability and functional size: the holy grail of combinatorial antibody library generation. Molecules. 2011;16:3675–700.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feldman J, Bals J, Altomare CG, St. Denis K, Lam EC, Hauser BM, et al. Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses. Sci Immunol. 2023;6:eabl5842.

Sarkar I, Garg R, van Drunen Littel-van den Hurk S. Selection of adjuvants for vaccines targeting specific pathogens. Expert Rev Vacc. 2019;18:505–21.

Reed SG, Orr MT, Fox CB. Key roles of adjuvants in modern vaccines. Nat Med. 2013;19:1597–608.

Article  CAS  PubMed  Google Scholar 

He B, Liu S, Wang Y, Xu M, Cai W, Liu J, et al. Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq. Signal Transduct Target Ther. 2021;6:195.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Setliff I, Shiakolas AR, Pilewski KA, Murji AA, Mapengo RE, Janowska K, et al. High-throughput mapping of B cell receptor sequences to antigen specificity. Cell. 2019;179:1636-1646.e15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hurtado J, Flynn C, Lee JH, Salcedo EC, Cottrell CA, Skog PD, et al. Efficient isolation of rare B cells using next-generation antigen barcoding. Front Cell Infect Microbiol. 2022;12:1–13.

Google Scholar 

Pilewski KA, Wall S, Richardson SI, Manamela NP, Clark K, Hermanus T, et al. Functional HIV-1/HCV cross-reactive antibodies isolated from a chronically co-infected donor. Cell Rep. 2023;42:112044.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lende SSF, Barnkob NM, Hansen RW, Bansia H, Vestergaard M, Rothemejer FH, et al. Discovery of neutralizing SARS-CoV-2 antibodies enriched in a unique antigen specific B cell cluster. PLoS ONE. 2023;18:1–26.

Article  Google Scholar 

Walker LM, Shiakolas AR, Venkat R, Liu ZA, Wall S, Raju N, et al. High-throughput B cell epitope determination by next-generation sequencing. Front Immunol. 2022;13:1–12.

Article  Google Scholar 

Shiakolas AR, Kramer KJ, Johnson NV, Wall SC, Suryadevara N, Wrapp D, et al. Efficient discovery of SARS-CoV-2-neutralizing antibodies via B cell receptor sequencing and ligand blocking. Nat Biotechnol. 2022;40:1270–5.

Article  CAS  PubMed  PubMed Central 

留言 (0)

沒有登入
gif